Zobrazeno 1 - 10
of 77
pro vyhledávání: '"R. Jane Rylett"'
Autor:
Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M. Crooks, Gerard Kyungwook Kim, Sophie Henke Tarnow, Amy Reichelt, Sara Memar, Daniel Palmer, Yulong Li, R. Jane Rylett, Lisa M. Saksida, Vania F. Prado, Marco A. M. Prado, Timothy J. Bussey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Nucleus accumbens cholinergic interneurons release acetylcholine and glutamate. Here, authors show that acetylcholine, rather than glutamate, is predominantly involved in updating dopamine dynamics mediating Pavlovian approach behaviours.
Externí odkaz:
https://doaj.org/article/f4d1dc4e75374f81957db4a31c2850f0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to determine the half-life of cellular proteins that overcomes the limitations of other commonl
Externí odkaz:
https://doaj.org/article/ef0ce01a37254f96849064e34697a6ad
Autor:
Warren Winick-Ng, R. Jane Rylett
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by synapse dysfunction and cognitive impairment. Understanding the development and progression of AD is challenging, as the disease is highly complex and multifactori
Externí odkaz:
https://doaj.org/article/cafec4763808485ea6165b971e6e0bb0
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS). One CMS-related mutation, V18M, reduce
Externí odkaz:
https://doaj.org/article/6f7e430a223a47008176558d502ad9dd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Alzheimer’s disease (AD) is a common age-related neurodegenerative disorder that is characterized by progressive cognitive decline. The deficits in cognition and attentional processing that are observed clinically in AD are linked to impaired funct
Externí odkaz:
https://doaj.org/article/c82004903d724dbbac88e0540faaa428
Autor:
Shawn Albers, Fatima Inthathirath, Sandeep K. Gill, Warren Winick-Ng, Ewa Jaworski, Daisy Y.L. Wong, Robert Gros, R. Jane Rylett
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 32-42 (2014)
Alzheimer disease (AD) is associated with increased amyloidogenic processing of amyloid precursor protein (APP) to β-amyloid peptides (Aβ), cholinergic neuron loss with decreased choline acetyltransferase (ChAT) activity, and cognitive dysfunction.
Externí odkaz:
https://doaj.org/article/5dd48c5d7f914475a8a73e1fc3656dcd
Publikováno v:
Canadian Journal on Aging / La Revue canadienne du vieillissement
Canadian Journal on Aging
Canadian Journal on Aging
RésuméCet article présente les domaines prioritaires de recherche sur les impacts de la pandémie de COVID-19 chez les personnes âgées telles qu’ils ont été identifiés par l’Institut du vieillissement des IRSC (IV-IRSC). Le processus util
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Assessing the stability and degradation of proteins is central to the study of cellular biological processes. Here, we describe a novel pulse-chase method to determine the half-life of cellular proteins that overcomes the limitations of other commonl
Autor:
Gregory A. Dekaban, Shawn Albers, R. Jane Rylett, Jennifer Yang, Natalie Kozyrev, Marco A. M. Prado, Vania F. Prado, Gregory J. Fonseca
Publikováno v:
Journal of neuropathology and experimental neurology. 79(11)
β-Amyloid (Aβ) plaques can trigger chronic inflammation in the cellular environment that recruits infiltrating macrophages during the course of Alzheimer disease (AD). Activated macrophages release pro-inflammatory cytokines that increase neurotoxi
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Despite important sex differences, there remains a paucity of studies examining sex and gender differences in neurodegeneration. The Canadian Consortium on Neurodegeneration in Aging (CCNA), a national network of researchers, provides an