Zobrazeno 1 - 10
of 48
pro vyhledávání: '"R. James Turner"'
Autor:
Ilias Alevizos, Corinne M. Goldsmith, Liesl Nottingham, Stamatina Danielides, John A. Chiorini, Jaime S. Brahim, Nikolay P. Nikolov, James B. Mitchell, Millie Whatley, Changyu Zheng, Deborah Citrin, Susan F. Rudy, Linda McCullagh, Carter Van Waes, Clara C. Chen, Bruce J. Baum, Shuying Liu, R. James Turner, Ana P. Cotrim, Peter D. Burbelo, Gabor G. Illei, Nicholas J. Patronas
Publikováno v:
Proceedings of the National Academy of Sciences. 109:19403-19407
No conventional therapy exists for salivary hypofunction in surviving head and neck cancer patients with Radiation Therapy Oncology Group late grade 2–3 toxicity. We conducted a phase I clinical trial to test the safety and biologic efficacy of ser
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C26-C37
The electroneutral cation-chloride cotransporter gene family, SLC12, contains nine members in vertebrates. These include seven sodium and/or potassium-coupled chloride transporters and two membrane proteins of unknown function. Although SLC12 family
Publikováno v:
Biochemistry. 46:9630-9637
The "secretory" Na+-K+-2Cl- cotransporter, NKCC1, is a member of a small gene family of electroneutral cation-chloride cotransporters (CCCs) with 9 homologues in vertebrates. A number of these transporters, including NKCC1 itself, have been shown to
Autor:
R. James Turner, Young S. Oh
Publikováno v:
Biochemical and Biophysical Research Communications. 346:330-334
The membrane-bound protein complex gamma-secretase is an intramembranous protease whose substrates are a number of type I transmembrane proteins including the beta-amyloid precursor protein (APP). A presenilin molecule is thought to be the catalytic
Autor:
Young S. Oh, R. James Turner
Publikováno v:
American Journal of Physiology-Cell Physiology. 291:C76-C82
Altered intracellular Ca2+signaling has been observed in cells derived from Alzheimer’s disease patients, and a possible link between γ-secretase activity and the content of intracellular Ca2+stores has been suggested. To test this hypothesis we s
Autor:
Young S. Oh, R. James Turner
Publikováno v:
American Journal of Physiology-Cell Physiology. 289:C576-C581
The polytopic membrane protein presenilin 1 (PS1) is a component of the gamma-secretase complex that is responsible for the intramembranous cleavage of several type I transmembrane proteins, including the beta-amyloid precursor protein (APP). Mutatio
Autor:
R. James Turner, Young S. Oh
Publikováno v:
Biochemistry. 44:11821-11828
Mutations of human presenilin 1 (PS1) have been genetically linked to early-onset familial Alzheimer's disease. PS1 contains 10 hydrophobic regions (HRs) sufficiently long to be alpha-helical membrane spanning segments. Most previous topology studies
Publikováno v:
Journal of Biological Chemistry. 279:38095-38098
The second messenger inositol 1,4,5-trisphosphate (IP(3)) plays a central role in the generation of a variety of spatiotemporally complex intracellular Ca(2+) signals involved in the regulation of many essential physiological processes. Here we descr
Autor:
R. James Turner, Yoko Dohke
Publikováno v:
Journal of Biological Chemistry. 277:15215-15219
Most polytopic membrane proteins are believed to integrate into the membrane of the endoplasmic reticulum (ER) cotranslationally. However, recent studies with Xenopus oocytes and dog pancreatic microsomes have suggested that this is not the case for
Publikováno v:
American Journal of Physiology-Cell Physiology. 282:C817-C823
We studied the phosphorylation of the secretory Na+-K+-2Cl−cotransporter (NKCC1) in rat parotid acinar cells. We have previously shown that NKCC1 activity in these cells is dramatically upregulated in response to β-adrenergic stimulation and that