Zobrazeno 1 - 10
of 2 658
pro vyhledávání: '"R. Jack"'
Autor:
Jie Li, Krzysztof Minczuk, Qiao Huang, Brandon A. Kemp, Nancy L. Howell, Mahendra D. Chordia, R. Jack Roy, James T. Patrie, Zoraiz Qureshi, Christopher M. Kramer, Frederick H. Epstein, Robert M. Carey, Bijoy K. Kundu, Susanna R. Keller
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 10 (2023)
Background Cardiac metabolic abnormalities are present in heart failure. Few studies have followed metabolic changes accompanying diastolic and systolic heart failure in the same model. We examined metabolic changes during the development of diastoli
Externí odkaz:
https://doaj.org/article/9011a48a5c1e4675bfa38921eb341a41
Autor:
Jie Li, Krzysztof Minćzuk, James C. Massey, Nancy L. Howell, R. Jack Roy, Soumen Paul, James T. Patrie, Christopher M. Kramer, Frederick H. Epstein, Robert M. Carey, Heinrich Taegtmeyer, Susanna R. Keller, Bijoy K. Kundu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 7 (2020)
Background In spontaneously hypertensive rats (SHR) we observed profound myocardial metabolic changes during early hypertension before development of cardiac dysfunction and left ventricular hypertrophy. In this study, we evaluated whether metformin
Externí odkaz:
https://doaj.org/article/2976b1f5f646458ba4346b53004a38e9
Autor:
Jie Li, Brandon A. Kemp, Nancy L. Howell, James Massey, Krzysztof Mińczuk, Qiao Huang, Mahendra D. Chordia, R. Jack Roy, James T. Patrie, Giovanni E. Davogustto, Christopher M. Kramer, Frederick H. Epstein, Robert M. Carey, Heinrich Taegtmeyer, Susanna R. Keller, Bijoy K. Kundu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Sustained pressure overload leads to changes in cardiac metabolism, function, and structure. Both time course and causal relationships between these changes are not fully understood. Therefore, we studied spontaneously hypertensive rats (S
Externí odkaz:
https://doaj.org/article/a109b40e233242ae8d4ca90b331b09f1
Publikováno v:
In Journal of Environmental Radioactivity March 2021 228
Autor:
Jianqiao Tian, Sheelakumari Raghavan, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Robel K. Gebre, Jonathan Graff-Radford, Christopher G. Schwarz, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri
Publikováno v:
Neurology. 100:e2269-e2278
Autor:
Sanaz Sedaghat, Yuekai Ji, Jean-Philippe Empana, Timothy M. Hughes, Thomas H. Mosley, Rebecca F. Gottesman, Michael Griswold, Clifford R. Jack, Pamela L. Lutsey, Thomas T. van Sloten
Publikováno v:
Stroke. 54:1280-1288
Background: Cardiovascular health may be used for prevention of cerebral vascular disease; however, data on the association of cardiovascular health across midlife and late-life with late-life cerebral vascular disease are lacking. Our aim was to exa
Autor:
Dror Shir, Michelle M. Mielke, Ekaterina I. Hofrenning, Timothy G. Lesnick, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Alicia Algeciras-Schimnich, Prashanthi Vemuri, Jonathan Graff-Radford
Publikováno v:
Journal of Alzheimer's Disease. 92:887-898
Background: The National Institute on Aging-Alzheimer’s Association Research Framework proposes defining Alzheimer’s disease by grouping imaging and fluid biomarkers by their respective pathologic processes. The AT(N) structure proposes several n
Autor:
Jaclyn Lilek, Kaouther Ajroud, Alexander Z. Feldman, Sesha Krishnamachari, Shadi Ghourchian, Tamar Gefen, Callen L. Spencer, Allegra Kawles, Qinwen Mao, Jessica F. Tranovich, Clifford R. Jack, M-Marsel Mesulam, R. Ross Reichard, Hui Zhang, Melissa E. Murray, David Knopman, Dennis W. Dickson, Ronald C. Petersen, Benjamin Smith, Karen H. Ashe, Michelle M. Mielke, Kathryn M. Nelson, Margaret E. Flanagan
Publikováno v:
Journal of Alzheimer's Disease. 92:241-260
Background: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. Objective: To address this
Autor:
Clifford R Jack, Heather J Wiste, Alicia Algeciras-Schimnich, Dan J Figdore, Christopher G Schwarz, Val J Lowe, Vijay K Ramanan, Prashanthi Vemuri, Michelle M Mielke, David S Knopman, Jonathan Graff-Radford, Bradley F Boeve, Kejal Kantarci, Petrice M Cogswell, Matthew L Senjem, Jeffrey L Gunter, Terry M Therneau, Ronald C Petersen
Publikováno v:
Brain. 146:2029-2044
Staging the severity of Alzheimer’s disease pathology using biomarkers is useful for therapeutic trials and clinical prognosis. Disease staging with amyloid and tau PET has face validity; however, this would be more practical with plasma biomarkers
Autor:
Irene, Sintini, Joseph R, Duffy, Heather M, Clark, Rene L, Utianski, Hugo, Botha, Mary M, Machulda, Matthew L, Senjem, Edythe A, Strand, Christopher G, Schwarz, Val J, Lowe, Clifford R, Jack, Keith A, Josephs, Jennifer L, Whitwell
Publikováno v:
Neurobiol Aging
Primary progressive apraxia of speech (PPAOS) is a neurodegenerative motor speech disorder affecting the ability to produce speech. If agrammatic aphasia is present, it can be referred to as the non-fluent/agrammatic variant of primary progressive ap