Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R. J. Weinkam"'
Publikováno v:
Investigative ophthalmologyvisual science. 31(7)
The ability of human and rabbit ocular tissues to degrade prostaglandins (PGs) was compared by following the metabolic fate of PGF2 alpha. No metabolism was observed in vitro after 5.0 hr incubation with human cornea, iris/ciliary body, or sclera, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9971ff1ab09c5105628c439178718ed4
https://pubmed.ncbi.nlm.nih.gov/2365570
https://pubmed.ncbi.nlm.nih.gov/2365570
Publikováno v:
Clinical Chemistry. 24:45-49
We used chemical ionization mass spectrometry to quantify the cancer chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea in biological fluids. A stable isotope-labeled internal standard was added to the fluid being analyzed. Protonated molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e489338b4852514d49c1d393cbeba28
https://doi.org/10.1093/clinchem/24.1.45
https://doi.org/10.1093/clinchem/24.1.45
Autor:
R. J. Weinkam, M. E. Dolan
Publikováno v:
Journal of Medicinal Chemistry. 26:1656-1659
The effect of five different 1-(2-chloroethyl)-1-nitrosoureas on the growth of cultured P388 cells has been analyzed in terms of physical, chemical, and kinetic parameters that are related to the mechanism of action of this class of cancer chemothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61146e49d5c08a255121a11e170bd319
https://doi.org/10.1021/jm00365a022
https://doi.org/10.1021/jm00365a022
Publikováno v:
Chemico-Biological Interactions. 31:167-177
The rates of chemical degradation of chloroethylnitrosoureas in serum are significantly higher than in aqueous buffer at the same pH and temperature. This rate enhancement is shown to be produced by a non-specific protein mediated chemical reaction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f334a3a40e3edaa5e56116d8c88fdb6
https://doi.org/10.1016/0009-2797(80)90003-4
https://doi.org/10.1016/0009-2797(80)90003-4
Autor:
Huey-shin. Lin, R. J. Weinkam
Publikováno v:
Analytical Chemistry. 51:972-975
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb836eaf4e7ddad027859efc59cc428
https://doi.org/10.1021/ac50043a044
https://doi.org/10.1021/ac50043a044
Publikováno v:
Instrumentation Science & Technology. 5:271-281
Relatively inexpensive and simple modifications to an AEI MS-902 double focusing high-resolution mass spectrometer allow chemical ionization studies to be undertaken without compromising the instrument's high resolving power or sensitivity. A standar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3ddee592002f9e5d47e542df3e0090
https://doi.org/10.1080/10739147308543377
https://doi.org/10.1080/10739147308543377
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 214(2)
Chloroethylnitrosoureas are anticancer agents that undergo chemical reactions in vitro and in vivo to form active alkylating agents. The rate at which lipophilic chloroethylnitrosourease decompose in serum is faster than in aqueous solution and compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bab447c53b59c9163aeb661235ae03f0
https://pubmed.ncbi.nlm.nih.gov/7391979
https://pubmed.ncbi.nlm.nih.gov/7391979
Publikováno v:
Cancer treatment reports. 62(9)
Using the technique of direct sample insertion selected ion monitoring chemical ionization mass spectroscopy, BCNU levels were measured in vivo in patients and in vitro in serum, sera ultrafiltrates, and buffered Ringer's solution. The disappearance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a44096d9203a6eece14a7caaf0b90e5
https://pubmed.ncbi.nlm.nih.gov/688274
https://pubmed.ncbi.nlm.nih.gov/688274
Autor:
M. E. Dolan, R. J. Weinkam
Publikováno v:
Chemischer Informationsdienst. 15
The effect of five different 1-(2-chloroethyl)-1-nitrosoureas on the growth of cultured P388 cells has been analyzed in terms of physical, chemical, and kinetic parameters that are related to the mechanism of action of this class of cancer chemothera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::838457ea63f0d183b4c02c2adbf029cd
https://doi.org/10.1002/chin.198415366
https://doi.org/10.1002/chin.198415366
Publikováno v:
Clinical chemistry. 24(1)
We used chemical ionization mass spectrometry to quantify the cancer chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea in biological fluids. A stable isotope-labeled internal standard was added to the fluid being analyzed. Protonated molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e558b396f2eed90e1ecb67684f10eb9b
https://pubmed.ncbi.nlm.nih.gov/618665
https://pubmed.ncbi.nlm.nih.gov/618665