Výsledky vyhledávání - "R. J. Shebuski"

Prevention of Reocclusion following Tissue Type Plasminogen Activator-Induced Thrombolysis by the RGD-Containing Peptide, Echistatin, in a Canine Model of Coronary Thrombosis

Autor: Marie A. Holahan, Michael J. Mellott, Victor M. Garsky, R J Shebuski

Publikováno v: Pharmacology. 42:340-348

We evaluated the effect of the RGD-containing peptide, echistatin, on thrombolysis time and acute reocclusion in a canine model of coronary thrombosis/thrombolysis. Occlusive thrombus formation was induced by electrical injury, via a stimulating elec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4410e9d6693d07e11cc5e0221be2eb
https://doi.org/10.1159/000138817

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Acceleration of recombinant tissue-type plasminogen activator-induced thrombolysis and prevention of reocclusion by the combination of heparin and the Arg-Gly-Asp-containing peptide bitistatin in a canine model of coronary thrombosis

Autor: G R Sitko, R J Shebuski, I J Stabilito, M H Polokoff

Publikováno v: Circulation. 82:169-177

The effect of tissue-type plasminogen activator (t-PA) alone or in combination with heparin, the Arg-Gly-Asp-containing peptide bitistatin, or both heparin and bitistatin was evaluated on thrombolysis time and acute reocclusion in a canine model of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa835af47750b287beff74c825812a4
https://doi.org/10.1161/01.cir.82.1.169

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Expression and characterisation of finger protease (FP); a mutant tissue-type plasminogen activator (t-PA) with improved pharmacokinetics

Autor: K L L Fong, K.E. Boyle, R. J. Shebuski, D. Williams, P. McDevitt, M.E. Reff, T.S. Sellers, M.D. Rosa, J.J. Trill, K. Johanson

Publikováno v: Fibrinolysis. 4:131-140

Summary We have constructed, expressed and purified a novel thrombolytic, finger protease (FP), composed of only the finger and serine protease domains of t-PA. This molecule, when compared to t-PA, has improved pharmacokinetics (slower plasma cleara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dad1b28d2e5178e09b8138b21c4370e9
https://doi.org/10.1016/s0268-9499(05)80044-x

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Temporal expression of c-fos mRNA following balloon injury in the rat common carotid artery

Autor: C J, Mills, J L, Northrup, T G, Hullinger, C A, Simmons, R J, Shebuski, D A, Jones

Publikováno v: Cardiovascular research. 32(5)

Restenosis is a common problem which limits the effectiveness of percutaneous transluminal coronary angioplasty (PTCA). The cellular mechanisms of restenosis appear to involve smooth muscle cell (SMC) migration to the neointima in response to mitogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::563c4797b070cbb7fa2cfc978f515a72
https://pubmed.ncbi.nlm.nih.gov/8944827

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Inhibition of thrombus formation by endothelin-1 in canine models of arterial thrombosis

Autor: R J, Leadley, W R, Humphrey, L A, Erickson, R J, Shebuski

Publikováno v: Thrombosis and haemostasis. 74(6)

The effect of endothelin-1 (ET-1) on thrombus formation in vivo was evaluated in two well-established canine models of coronary artery thrombosis. First, the possible antithrombotic effect of ET-1 was examined using the cyclic flow reduction (CFR) mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a5e8d8134d3cdc6a92d5d53c49a8247
https://pubmed.ncbi.nlm.nih.gov/8772241

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Pretreatment with a blocking monoclonal antibody to P-selectin accelerates pharmacological thrombolysis in a primate model of arterial thrombosis

Autor: C F, Toombs, G L, DeGraaf, J P, Martin, J G, Geng, D C, Anderson, R J, Shebuski

Publikováno v: The Journal of pharmacology and experimental therapeutics. 275(2)

It has been established that the fibrin content of a developing thrombus can be dramatically reduced with the use of the GA6 monoclonal antibody, which is directed against P-selectin (CD62p). This effect is probably related to diminished tissue facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::778385633e2ae252036ada15d065a961
https://pubmed.ncbi.nlm.nih.gov/7473186

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Protection of ischemic/reperfused canine myocardium by CL18/6, a monoclonal antibody to adhesion molecule ICAM-1

Autor: J C, Hartman, D C, Anderson, A L, Wiltse, C L, Lane, C L, Rosenbloom, A M, Manning, W R, Humphrey, T M, Wall, R J, Shebuski

Publikováno v: Cardiovascular research. 30(1)

A blocking monoclonal antibody to intercellular adhesion molecule-1 (ICAM-1), CL18/6, previously has been demonstrated to inhibit neutrophil attachment to isolated vascular endothelium and cardiomyocytes. Due to the well known participation of ICAM-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69d0947547184a82754b591d91ad9877
https://pubmed.ncbi.nlm.nih.gov/7553723

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