Zobrazeno 1 - 7
of 7
pro vyhledávání: '"R. J. Scott Lacombe"'
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 412-420 (2019)
Tetracosahexaeoic acid (THA; 24:6n-3) is thought to be the immediate precursor of DHA in rodents; however, the relationship between THA and DHA metabolism has not been assessed in vivo. Here, we infused unesterified 2H5-THA and 13C22-DHA, at a steady
Externí odkaz:
https://doaj.org/article/bc5c6e4935564ba6ab2adf5348c7472f
Autor:
Adam H. Metherel, R. J. Scott Lacombe, Raphaël Chouinard-Watkins, Kathryn E. Hopperton, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 357-367 (2018)
Previous assessments of the PUFA biosynthesis pathway have focused on DHA and arachidonic acid synthesis. Here, we determined whole-body synthesis-secretion kinetics for all downstream products of PUFA metabolism, including direct measurements of DHA
Externí odkaz:
https://doaj.org/article/0910da2f09cc49d9ba7c0c58f5c5a9fe
Autor:
Adam H. Metherel, Raphaël Chouinard-Watkins, Marc-Olivier Trépanier, R. J. Scott Lacombe, Richard P. Bazinet
Publikováno v:
Nutrition & Metabolism, Vol 14, Iss 1, Pp 1-8 (2017)
Abstract Dietary docosahexaenoic acid (DHA, 22:6n-3) not only increases blood and tissue levels of DHA, but also eicosapentaenoic acid (EPA, 20:5n-3). It is generally believed that this increase is due to DHA retroconversion to EPA, however, a slower
Externí odkaz:
https://doaj.org/article/b00224845ec449e283f681a485bfb3af
Autor:
R. J. Scott Lacombe, Vanessa Giuliano, Stefanie M. Colombo, Michael T. Arts, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 2071-2081 (2017)
DHA (22:6n-3) may be derived from two dietary sources, preformed dietary DHA or through synthesis from α-linolenic acid (ALA; 18:3n-3). However, conventional methods cannot distinguish between DHA derived from either source without the use of costly
Externí odkaz:
https://doaj.org/article/4486a049c9b54ac89d950143e8231c72
Autor:
R. J. Scott Lacombe, Mackenzie E. Smith, Kelly Perlman, Gustavo Turecki, Naguib Mechawar, Richard P. Bazinet
Publikováno v:
Journal of Neurochemistry. 164:44-56
Our knowledge surrounding the overall fatty acid profile of the adult human brain has been largely limited to extrapolations from brain regions in which the distribution of fatty acids varies. This is especially problematic when modeling brain fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2cedfea0b9ed223f40d941401915e9
https://doi.org/10.1111/jnc.15702
https://doi.org/10.1111/jnc.15702
Autor:
Dong Hao Wang, Dragoslav Vidovic, Alasdair I. McKay, Tamim Darwish, Hui Gyu Park, Secilia Martinez Garza, Samuel W. Shields, Jennifer S. Brodbelt, Zhen Wang, R. J. Scott Lacombe, Vadim V. Shmanai, Ivan L. Lysenko, Andrei V. Bekish, Karsten Schmidt, Christina Redfield, J. Thomas Brenna, Mikhail S. Shchepinov
Publikováno v:
Analytical chemistry. 94(38)
Ru-based catalysis results in highly unsaturated fatty acid (HUFA) ethyl esters (EE) deuterated to various extents. The products carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1214984a2e40e926c891b600657e3b50
https://pubmed.ncbi.nlm.nih.gov/36098546
https://pubmed.ncbi.nlm.nih.gov/36098546
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 12, Pp 2102-(2019)
Tetracosahexaeoic acid (THA; 24:6n-3) is thought to be the immediate precursor of DHA in rodents; however, the relationship between THA and DHA metabolism has not been assessed in vivo. Here, we infused unesterified (2)H(5)-THA and (13)C(22)-DHA, at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44b291108a6387f155bbfd4226362ed
https://europepmc.org/articles/PMC6889710/
https://europepmc.org/articles/PMC6889710/
