Zobrazeno 1 - 10 of 24 pro vyhledávání: '"R. J. Samulski"'
1
Methods for the construction and propagation of recombinant adeno-associated virus vectors
Autor: J S, Bartlett, R J, Samulski
Publikováno v: Methods in molecular medicine. 7
The development of gene transfer vectors from the human parvovirus, adeno-associated virus (AAV), has provided scientists with an efficient and effective way of delivering genes into mammalian cells. This chapter aims to explore the various practical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64a6ec1be4665b11a09fecdb8315c6ce
https://pubmed.ncbi.nlm.nih.gov/24493416
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2
Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters
Autor: J S Bartlett, R J Samulski, S A Gowen, L Ramamurthy, W F Marzluff, M Sethna
Publikováno v: Proceedings of the National Academy of Sciences. 93:8852-8857
Few promoters are active at high levels in all cells. Of these, the majority encode structural RNAs transcribed by RNA polymerases I or III and are not accessible for the expression of proteins. An exception are the small nuclear RNAs (snRNAs) transc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8137af09102360a07a83057ed06dff
https://doi.org/10.1073/pnas.93.17.8852
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4
Abstract 2882: Directed Evolution of Cardiac Specific Adeno-Associated Vector Variants
Autor: Roger J Hajjar, Jiqiu Chen, Yoshiaki Kawase, Scott McPhee, Jade Samulski, R. J Samulski
Publikováno v: Circulation. 118
Adeno-associated vectors (AAV) have gained popularity in cardiovascular gene transfer because of their distinct characteristics: long-term expression, minimal immune response and strong tropism to cardiac tissue for specific serotypes (such as AAV9).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a3b9f2be6408d0ec6598372f387df4e
https://doi.org/10.1161/circ.118.suppl_18.s_791-d
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6
AAV Vectors, the Future Workhorse of Human Gene Therapy
Autor: R. J. Samulski
Publikováno v: Human Gene Therapy: Current Opportunities and Future Trends ISBN: 9783662053546
Adeno-associated virus type 2 (AAV2) is a human parvovirus with a single-stranded DNA genome of approximately 4.68 kb. AAV2 is dependent on co-infection with a helper virus, such as adenovirus or herpes virus, to facilitate its replication. The genom
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::343b49138bc48c26d3b9c4307e637581
https://doi.org/10.1007/978-3-662-05352-2_3
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9
Adeno-associated viral vectors as gene delivery vehicles
Autor: P J Carter, R J Samulski
Publikováno v: International Journal of Molecular Medicine.
Adeno-associated virus (AAV), a non-pathogenic human parvovirus, is gaining attention for its potential use as a human gene therapy vector. One of the most attractive features of recombinant AAV vectors is the ability to be stably maintained in host
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbd8d045610b30dc742651fe32d145d
https://doi.org/10.3892/ijmm.6.1.17
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10
Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat
Autor: T G, Lehmann, M D, Wheeler, R, Schoonhoven, H, Bunzendahl, R J, Samulski, R G, Thurman
Publikováno v: Transplantation. 69(6)
Oxygen-derived free radicals play a central role in pathomechanisms of reperfusion injury after organ transplantation. Endogenous radical scavenger systems such as superoxide dismutase (SOD) degrade toxic radicals; however, SOD is degraded rapidly wh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5c4bbfcbdcfaa3a527a281f5aeefc2dc
https://pubmed.ncbi.nlm.nih.gov/10762207
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