Zobrazeno 1 - 10
of 48
pro vyhledávání: '"R. J. Lynch"'
Autor:
David A. Jefferson, Richard M. Lambert, R. J. Lynch, Dejian Zhou, Alexander Orlov, M. S. Chan
Publikováno v:
Environmental Technology. 27:747-752
Well characterised novel catalysts consisting of TiO2 modified with very small amounts of gold nanoparticles have been applied to the photocatalytic degradation of two important pollutants, methyl tert-butyl ether (MTBE) and 4-chlorophenol, in dilute
Publikováno v:
physica status solidi (c). :2055-2058
In the absence of the use of prevention methods, AlGaN layers on GaN are known to form an array of cracks if a critical thickness is exceeded. In this study growth of AlGaN–GaN structures was carried out by metalorganic vapour phase epitaxy using s
Publikováno v:
physica status solidi (a). 188:641-645
GaN low temperature nucleation and high temperature buffer layers have been grown by metalorganic vapour phase epitaxy. The effect of nucleation layer annealing temperature and buffer layer growth temperature on their microstructure and morphology ha
Autor:
Adel M. Naylor-Olsen, Jacquelynn J. Cook, Robert J. Meissner, Amy E. Zartman, William F. Hoffman, Robert J. Gould, Guixiang Zhang, George D. Hartman, Joan D. Glass, R. J. Lynch, Mark E. Duggan, James J. Perkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:863-868
A new series of potent, linearly-minimized, orally active, selective GPIIb/IIIa inhibitors is identified. Thus 15 (L-750,034) achieves interaction via a constrained, non-turned conformation that maintains the proper distance between its charged termi
Autor:
B. C. Askew, Thomayant Prueksaritanont, Joseph J. Lynch, Charles J. Mcintyre, Terrence G. Hamill, Rodney A. Bednar, Marie A. Holahan, Stanley L. Gaul, R. J. Lynch, G. R. Sitko, Robert J. Gould, Joan D. Glass, Cecila A. Hunt, John J. Baldwin, Jacquelynn J. Cook, Lynn M. Gorham, George D. Hartman, David A. Claremon, Maria T. Stranieri, Bohumil Bednar
Publikováno v:
Journal of Medicinal Chemistry. 40:1779-1788
The synthesis and pharmacological evaluation of 5 (L-738, 167), a potent, selective non-peptide fibrinogen receptor antagonist is reported. Compound 5 inhibited the aggregation of human gel-filtered platelets with an IC50 value of 8 nM and was found
Autor:
G. R. Sitko, Robert J. Gould, S. Lee Gaul, Guixiang Zhang, John D. Prugh, Bohumil Bednar, Maria T. Stranieri, Rodney A. Bednar, Marie A. Holahan, Jacquelynn J. Cook, George D. Hartman, R. J. Lynch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:865-870
Centrally constrained thieno[2,3- b ]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound 21 showed excellent activity in the dog after a single oral dose of 200 μg/kg.
Autor:
R. J. Lynch, Rodney A. Bednar, Bohumil Bednar, Jacquelynn J. Cook, L.M. Vassallo, Marie A. Holahan, Stanley L. Gaul, Melissa S. Egbertson, Laura A. Libby, G. R. Sitko, Robert J. Gould, J.J. Lynch, George D. Hartman, Maria T. Stranieri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2519-2524
Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constra
Autor:
Maria T. Stranieri, Wasyl Halczenko, R. J. Lynch, George D. Hartman, Joan D. Glass, John H. Hutchinson, Michael J. Breslin, G. R. Sitko, Marie A. Holahan, Robert J. Gould, Jacquelynn J. Cook, Karen M. Brashear
Publikováno v:
Journal of Medicinal Chemistry. 39:4583-4591
The structure-activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen heterocycle grafted onto a 3,4-dihydro-1 (1H)-isoquinolinone core is described. These compounds are structurally novel analogs of
High-reflectivity AlxGa1−xN∕AlyGa1−yN distributed Bragg reflectors with peak wavelength around 350nm
Autor:
A. Alyamani, Peter J. Parbrook, D. M. Whittaker, R. J. Lynch, Raphaël Butté, Daniele Sanvitto, Tao Wang, M. S. Skolnick
Publikováno v:
Applied Physics Letters. 85:43-45
Al0.49Ga0.51N∕Al0.16Ga0.84N distributed Bragg reflectors (DBRs), designed for the ultraviolet spectral region, are reported. The crack-free structures are grown on sapphire substrates by metalorganic chemical vapor deposition. A peak reflectivity o
Autor:
David A. Claremon, Charles J. Mcintyre, Robert J. Gould, B. C. Askew, D. J. Armstrong, R. J. Lynch, Hunt Cecilia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:475-480
Low molecular weight non-peptide inhibitors of platelet aggregation based on rigid bicyclic scaffolds are described. Consideration of the reported conformational preferences of 1-alkyl-3-carbonyl pyrroles led to the synthesis of pyrrolopiperazinone 2