Zobrazeno 1 - 10
of 28
pro vyhledávání: '"R. J. Lozito"'
Autor:
Gary M. Coppola, Xilin Liu, Robert C. Anderson, Douglas C. Knorr, William S. Fillers, James L. Stanton, Jiaping Gao, Tomaselli Hc, Christine C. Vinluan, Thomas Daniel Aicher, Carol J. Dragland, Suraj S. Shetty, Wieslawa Maniara, A. Islam, Emma L. Kaplan, William R. Mann, Leonard J. Brand, Donald Mark Sperbeck, R. E. Walter, Dominick DelGrande, R. J. Lozito
Publikováno v:
Journal of Medicinal Chemistry. 43:236-249
N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+
https://doi.org/10.1021/jm990358+
Autor:
Emma L. Kaplan, Gary M. Coppola, Xilin Liu, Gregory Raymond Bebernitz, Donald Mark Sperbeck, Dominick DelGrande, Wieslawa Maniara, Leonard J. Brand, Suraj S. Shetty, Thomas Daniel Aicher, Robert C. Anderson, Charles F. Jewell, R. J. Lozito, Douglas C. Knorr, A. Islam, Chen Liu, Christine C. Vinluan, Jianping Gao, Robert J. Strohschein, William R. Mann, Carol J. Dragland, R. E. Walter
Publikováno v:
Journal of Medicinal Chemistry. 42:2741-2746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584
https://doi.org/10.1021/jm9902584
Autor:
T D, Aicher, R C, Anderson, J, Gao, S S, Shetty, G M, Coppola, J L, Stanton, D C, Knorr, D M, Sperbeck, L J, Brand, C C, Vinluan, E L, Kaplan, C J, Dragland, H C, Tomaselli, A, Islam, R J, Lozito, X, Liu, W M, Maniara, W S, Fillers, D, DelGrande, R E, Walter, W R, Mann
Publikováno v:
Journal of medicinal chemistry. 43(2)
N'-methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC(50) = 180 microM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b1772832e8ae976302ee3c02cf1e34f5
https://pubmed.ncbi.nlm.nih.gov/10649979
https://pubmed.ncbi.nlm.nih.gov/10649979
Publikováno v:
Journal of Applied Physiology. 64:1094-1097
An experimental model for investigating the disparate effects of obesity and hypertension on the heart was developed by ligation of the aorta of male Sprague-Dawley rats made obese through ad libitum feeding. Experimental obesity was associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba221ba8b4b5e710532b10740b15b54a
https://doi.org/10.1152/jappl.1988.64.3.1094
https://doi.org/10.1152/jappl.1988.64.3.1094
Publikováno v:
Research communications in chemical pathology and pharmacology. 53(2)
The effects of dietary sucrose upon specific myocardial and hemodynamic parameters were examined in spontaneously hypertensive rats (SHR). Following a 6 wk program, SHR consuming a supplement of 10% sucrose in the drinking water exhibited increased h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::346d99949792857667574143177b1d9e
https://pubmed.ncbi.nlm.nih.gov/3020652
https://pubmed.ncbi.nlm.nih.gov/3020652
Autor:
Grygorenko, Oleksandr O.1,2 (AUTHOR) gregor@univ.kiev.ua, Volochnyuk, Dmitriy M.1,2,3 (AUTHOR), Vashchenko, Bohdan V.1,2 (AUTHOR)
Publikováno v:
European Journal of Organic Chemistry. 12/21/2021, Vol. 2021 Issue 47, p6478-6510. 33p.
Autor:
Wei, Mingjie1 (AUTHOR), Liang, Dacheng1 (AUTHOR), Cao, Xiaohui2 (AUTHOR), Luo, Wenjun1 (AUTHOR), Ma, Guojian1 (AUTHOR), Liu, Zeyuan1 (AUTHOR), Li, Le1 (AUTHOR) lile26@mail.sysu.edu.cn
Publikováno v:
Angewandte Chemie. 3/22/2021, Vol. 133 Issue 13, p7473-7480. 8p.
Autor:
Liashuk OS; Enamine Ltd. (www.enamine.net), Winston Churchill Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyїv, 01601, Ukraine., Andriashvili VA; Enamine Ltd. (www.enamine.net), Winston Churchill Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyїv, 01601, Ukraine., Tolmachev AO; Enamine Ltd. (www.enamine.net), Winston Churchill Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyїv, 01601, Ukraine., Grygorenko OO; Enamine Ltd. (www.enamine.net), Winston Churchill Street 78, Kyїv, 02094, Ukraine.; Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyїv, 01601, Ukraine.
Publikováno v:
Chemical record (New York, N.Y.) [Chem Rec] 2024 Feb; Vol. 24 (2), pp. e202300256. Date of Electronic Publication: 2023 Oct 12.
Autor:
Pan, Qijun, Liu, Yongan, Pang, Wan, Wu, Jingjing, Ma, Xiaoyu, Hu, Xiaojun, Guo, Yong, Chen, Qing-Yun, Liu, Chao
Publikováno v:
Organic & Biomolecular Chemistry; Nov2021, Vol. 19 Issue 41, p8999-9003, 5p
Publikováno v:
Angewandte Chemie. Dec2012, Vol. 124 Issue 49, p12385-12389. 5p.