Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R. J. Lindmark"'
Autor:
Wendy P. Gati, John S. Wilson, Stanislaw F. Wnukt, D. Lorne Tyrrell, R. J. Lindmark, Morris J. Robins, Danuta Madej
Publikováno v:
Journal of Heterocyclic Chemistry. 38:1297-1306
Selected 2,6-(disubstituted)purine 2′,3′-didehydro-2′,3′-dideoxynucleosides and 2′,3′-dideoxynucleosides were prepared and evaluated. Treatment of 5′-protected ribonucleosides with phenoxythiocarbonyl chloride and 4-(dimethylamino)pyrid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::870acbf56f4101918bb82dadf848223d
https://doi.org/10.1002/jhet.5570380609
https://doi.org/10.1002/jhet.5570380609
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Publikováno v:
The Journal of Organic Chemistry. 58:7948-7951
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffaacd87d196a3ddd3eabd7e87666551
https://doi.org/10.1021/jo00079a054
https://doi.org/10.1021/jo00079a054
Autor:
Nancy S. Nicholson, Jeffery Alan Zablocki, R. J. Lindmark, D Pireh, Robert Bruce Garland, Beatrice B. Taite, Masateru Miyano, Shashidhar N. Rao, L Schretzman, S.G. Panzer-Knodle
Publikováno v:
Journal of Medicinal Chemistry. 36:1811-1819
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418001710ed44efdbaa4f9aa830654d
https://doi.org/10.1021/jm00065a003
https://doi.org/10.1021/jm00065a003
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b7253f52348da0f4daf5dec7203cd6
https://doi.org/10.1002/chin.199420239
https://doi.org/10.1002/chin.199420239
Autor:
Wendy P. Gati, D. Madej, John Wilson, D. Lorne J. Tyrrell, R. J. Lindmark, Stanislaw F. Wnuk, Morris J. Robins
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0adcbcca8f39dca9e16de8f326725e9d
https://doi.org/10.1002/chin.200217213
https://doi.org/10.1002/chin.200217213
Autor:
J A, Zablocki, J G, Rico, R B, Garland, T E, Rogers, K, Williams, L A, Schretzman, S A, Rao, P R, Bovy, F S, Tjoeng, R J, Lindmark
Publikováno v:
Journal of medicinal chemistry. 38(13)
Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our i.v. antiplatelet agent (SC-52012) demonstrated modest oral activity in canine studies (ethyl [5-(4-amindinophen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f8b6ef5701f22716b8436aba26c226
https://pubmed.ncbi.nlm.nih.gov/7608903
https://pubmed.ncbi.nlm.nih.gov/7608903
Autor:
Nancy S. Nicholson, J. G. Rico, Kenneth Williams, Foe S. Tjoeng, P. R. Bovy, Lucy W. King, Anita K. Salyers, Lori Ann Schretzman, Beatrice B. Taite, Robert B. Garland, Masateru Miyano, Susan G. Panzer-Knodle, Jeffery A. Zablocki, R. J. Lindmark, Mihaly V. Toth, Dudley E. McMackins, James G. Campion, Mark E. Zupec, Larry P. Feigen, Steven Paul Adams
Publikováno v:
Bioorganicmedicinal chemistry. 3(5)
A novel series of orally active fibrinogen receptor antagonists has been discovered through structural modification of our lead intravenous (iv) antiplatelet agent, 5-(4-amidinophenyl)pentanoyl-Asp-Phe 1 (SC-52012). The Asp-Phe amide bond was removed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457021deb18f6befd4e2a794535a39c6
https://pubmed.ncbi.nlm.nih.gov/7648203
https://pubmed.ncbi.nlm.nih.gov/7648203
Autor:
P. R. Bovy, F. S. Tjoeng, J. G. Rico, T. E. Rogers, R. J. Lindmark, J. A. Zablocki, R. B. Garland, D. E. McMackins, H. Dayringer, M. V. Tóth, M. E. Zupec, S. Rao, S. G. Panzer-Knodle, N. S. Nicholson, A. Salyers, B. B. Taite, M. F. Hérin, M. Miyano, L. P. Feigen, S. P. Adams
Publikováno v:
Peptides 1994 ISBN: 9789072199218
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::620b95f8fea5dddf6249efa11071a7a5
https://doi.org/10.1007/978-94-011-1468-4_25
https://doi.org/10.1007/978-94-011-1468-4_25
Autor:
D. E. Mcmackins, Nancy S. Nicholson, Jeffery Alan Zablocki, Thomas E. Rogers, Mihaly V. Toth, Steven Paul Adams, Beatrice B. Taite, Anita K. Salyers, M. Miyano, M. E. Zupec, R. B. Garland, R. J. Lindmark, F. S. Tjoeng, Larry P. Feigen, P. R. Bovy, J. G. Rico, S G Panzer-Knodle
Publikováno v:
Peptides ISBN: 9789401042956
Peptides
Peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dad2aa1184fb4053127c0246eabcc23b
https://doi.org/10.1007/978-94-011-0683-2_101
https://doi.org/10.1007/978-94-011-0683-2_101