Zobrazeno 1 - 10 of 108 pro vyhledávání: '"R. J. Levinsky"'
1
Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH-I monoclonal antibody and E-rosetting
Autor: Lj Knott, R. J. Levinsky, G. Hale, David C. Linch, E. G. Davies, J. M. Chessells, Colin A. Sieff, Herman Waldmann, Gareth J. Morgan
Six patients with severe combined immunodeficiency were transplanted with bone marrow from their HLA haploidentical parents. T-lymphocytes were removed by complement mediated lysis with a monoclonal antibody (CAMPATH-I) followed by rosetting with she
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d97d492325a120d33af2fb09e99b8e4
https://doi.org/10.1111/j.1365-2141.1986.tb02953.x
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2
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
Autor: G O Cory, L MacCarthy-Morrogh, S Banin, I Gout, P M Brickell, R J Levinsky, C Kinnon, R C Lovering
Publikováno v: The Journal of Immunology. 157:3791-3795
Wiskott-Aldrich syndrome is an X-linked combined immunodeficiency affecting cells of several different hemopoietic lineages. The Wiskott-Aldrich syndrome protein (WASP), which has no homology with any other known protein families, is rich in proline
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37ebec1dae08581f5ffa7837284f8bf0
https://doi.org/10.4049/jimmunol.157.9.3791
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3
p22-phox-deficient chronic granulomatous disease: reconstitution by retrovirus-mediated expression and identification of a biosynthetic intermediate of gp91-phox
Autor: C D, Porter, M H, Parkar, A J, Verhoeven, R J, Levinsky, M K, Collins, C, Kinnon
Publikováno v: Blood. 84:2767-2775
Chronic granulomatous disease (CGD) results from defects in the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, central to which is the membrane-bound cytochrome b-245. The cytochrome is composed of two protein subunits, the la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29385708232c0ac203c9b8436a095387
https://doi.org/10.1182/blood.v84.8.2767.bloodjournal8482767
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4
X-linked chronic granulomatous disease: correction of NADPH oxidase defect by retrovirus-mediated expression of gp91-phox
Autor: C D, Porter, M H, Parkar, R J, Levinsky, M K, Collins, C, Kinnon
Publikováno v: Blood. 82:2196-2202
Chronic granulomatous disease (CGD) is an inherited immunodeficiency resulting from the inability of an individual's phagocytes to produce superoxide anions because of defective NADPH oxidase. The disease may be treated by bone marrow transplantation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae16bc5a55441b3bd094f90a640cf976
https://doi.org/10.1182/blood.v82.7.2196.bloodjournal8272196
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5
Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow
Autor: L K, Ashman, A C, Cambareri, L B, To, R J, Levinsky, C A, Juttner
Publikováno v: Blood. 78:30-37
The c-kit proto-oncogene product is a member of the family of growth factor receptors with intrinsic tyrosine kinase activity. In the mouse c-kit maps to the W locus, which is known to be of central importance in hematopoiesis. Monoclonal antibody (M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb38936d1ce99054e7f9e2561dcf7f9
https://doi.org/10.1182/blood.v78.1.30.bloodjournal78130
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7
Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency
Autor: John A. Duley, H A Simmonds, D. A. Hopkinson, R. J. Levinsky
Publikováno v: Clinica Chimica Acta. 188:243-252
A complete deficiency of inosine triphosphate pyrophosphohydrolase (ITPase) has been identified, together with high concentrations (mean 157 mumol/l) of the unusual nucleotide ITP, in the erythrocytes of 3 members of a consanguineous United Kingdom k
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e3b39363d2f2dd61c2e87ea6f8c7fe
https://doi.org/10.1016/0009-8981(90)90206-8
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8
The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations
Autor: R. J. Levinsky, Malcolm W. Turner, Michael Super
Publikováno v: Clinical and Experimental Immunology. 79:144-150
SUMMARY When sera diluted to 5% in a buffer containing calcium and magnesium were incubated with mannancoated ELISA plates, C4 fragments, properdin and factor B were bound to the plates as well as the expected opsonic C3 fragments, C3b and C3bi. The
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd24547d4bc62e9dc81d8879c69c9f3
https://doi.org/10.1111/j.1365-2249.1990.tb05170.x
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9
Bruton's tyrosine kinase expression and activity in X-linked agammaglobulinaemia (XLA): the use of protein analysis as a diagnostic indicator of XLA
Autor: H B, Gaspar, T, Lester, R J, Levinsky, C, Kinnon
Publikováno v: Clinical and experimental immunology. 111(2)
Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b17ea48b6f3b7ab9e6e52e5f8f3145e6
https://pubmed.ncbi.nlm.nih.gov/9486400
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10
Efficient retroviral transduction of human bone marrow progenitor and long-term culture-initiating cells: partial reconstitution of cells from patients with X-linked chronic granulomatous disease by gp91-phox expression
Autor: C D, Porter, M H, Parkar, M K, Collins, R J, Levinsky, C, Kinnon
Publikováno v: Blood. 87(9)
The primary immunodeficiencies are attractive candidates for the development of gene therapy approaches based on the transduction of hematopoietic cells. We have constructed a high-titer recombinant retrovirus for expression of gp91-phox, deficiencie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8638519dd7a751cff2310731c1484550
https://pubmed.ncbi.nlm.nih.gov/8611697
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