Zobrazeno 1 - 10
of 47
pro vyhledávání: '"R. J. Laib"'
Publikováno v:
Toxicological & Environmental Chemistry. 34:19-22
Since about 1980 only technical mixtures of low‐chlorinated biphenyls have been used in the Federal Republic of Germany. Although these are more readily degraded in the environment than mixtures containing high‐chlorinated compounds, low‐chlori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c8ab2e14776f770db71717d13090dd4
https://doi.org/10.1080/02772249109357772
https://doi.org/10.1080/02772249109357772
Autor:
R. J. Laib, Antoine Vercruysse, Miranda Cornet, Georg Csanády, Vera Rogiers, Walter Sonck, Andre Callaerts
Publikováno v:
Vrije Universiteit Brussel
Until now, no data are available concerning the biotransformation and toxicity of 2-methylpropene (or isobutene), a gaseous alkene widely used in industry (rubber, fuel additives, plastic polymers, adhesives, antioxidants). In this work, the biotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9705bedbc34289b0c2795618d4af026
https://doi.org/10.1007/bf01968959
https://doi.org/10.1007/bf01968959
Publikováno v:
Environ. Health Perspect. 86, 57-63 (1990)
Environmental Health Perspectives
Environmental Health Perspectives
Studies were conducted on inhalation pharmacokinetics of 1,3-butadiene and of its primary reactive metabolic intermediate 1,2-epoxybutene-3 in rats (Sprague-Dawley) and mice (B6C3F1). Investigations of inhalation pharmacokinetics of 1,3-butadiene rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae360d0127b619db3ad62868868083e1
https://doi.org/10.1289/ehp.908657
https://doi.org/10.1289/ehp.908657
Publikováno v:
Environ. Health Perspect. 86, 89-92 (1990)
Environmental Health Perspectives
Environmental Health Perspectives
Studies on inhalation pharmacokinetics of isoprene were conducted in rats (Wistar) and mice (B6C3F1) to investigate possible species differences in metabolism of this compound. Pharmacokinetic analysis of isoprene inhaled by rats and mice revealed sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22a1aac5b25104eb515bcb35681f696
https://doi.org/10.1289/ehp.908689
https://doi.org/10.1289/ehp.908689
Autor:
G. A. Csanády, R. J. Laib
Publikováno v:
Archives of Toxicology. 64:594-596
A relationship between the partition coefficient (P) and the boiling point (TBp, expressed in degrees Kelvin) was derived as TBp = alpha *ln(P) + beta. The relationship is based on the Clausius-Clapeyron equation and is valid for volatile lipophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb94adbeeb52ea2d548a953dfee647
https://doi.org/10.1007/bf01971841
https://doi.org/10.1007/bf01971841
Publikováno v:
Toxicology letters. 75(1-3)
Olefinic hydrocarbons are metabolized in vivo by cytochrome P450-dependent monooxygenases to the corresponding epoxides. The maximum in vivo metabolic rate, which is an important toxicokinetic parameter, has been used to define the apparent rate cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f16a9e91d2e6069f61c7b774cc36d9
https://pubmed.ncbi.nlm.nih.gov/7863530
https://pubmed.ncbi.nlm.nih.gov/7863530
Publikováno v:
Mutagenesis. 8(5)
Four structurally related aliphatic epoxides (1,2-epoxypropane, 1,2-epoxyisobutane, cis- and trans-2,3-epoxybutane) have been tested in the Salmonella/microsome assay, modified for volatile substances, using the strains TA1535 and TA100. The aim of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4429cf4d04389678a6d091521cdb6ded
https://pubmed.ncbi.nlm.nih.gov/8231818
https://pubmed.ncbi.nlm.nih.gov/8231818
Publikováno v:
Archives of toxicology. 67(1)
The alkaline filter elution technique was used to evaluate single strand breaks (SSB), DNA-DNA (DDCL) and DNA-protein cross-links (DPCL) in liver and lung of male rats (Sprague-Dawley) and male mice (B6C3F1) after exposure to 2000 ppm 1,3-butadiene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba63ff5bc81e7996bcf3d001d85e79ff
https://pubmed.ncbi.nlm.nih.gov/8452477
https://pubmed.ncbi.nlm.nih.gov/8452477
Publikováno v:
Archives of toxicology. 66(5)
Gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in Sprague-Dawley rats. The animals were co-exposed by inhalation to a mixture of 1,3-butadiene between 20 and 6000 ppm (v/v) and styrene between 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b224be163431027b84e7c91c0b65081
https://pubmed.ncbi.nlm.nih.gov/1610292
https://pubmed.ncbi.nlm.nih.gov/1610292
Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats
Autor:
Johannes G. Filser, Miranda Cornet, Vera Rogiers, D. Freise, B. Denk, R. J. Laib, G. A. Csanády
Publikováno v:
Vrije Universiteit Brussel
Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc914236d8275713a76a91c96d6f66a
https://hdl.handle.net/20.500.14017/56622a58-e0eb-42ea-a258-ce945742c30c
https://hdl.handle.net/20.500.14017/56622a58-e0eb-42ea-a258-ce945742c30c
