Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R. J. KNOX"'
Autor:
R. J. Knox, Geoffrey V.F. Seaman, Nancy B. Beamer, Y. Tan, L. Mela-Riker, B.M. Coull, F. J. Nordt
Publikováno v:
Clinical Hemorheology and Microcirculation. 9:273-280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24fefb0fc0a8d710e0ec4760dbfbdd3d
https://doi.org/10.3233/ch-1989-9209
https://doi.org/10.3233/ch-1989-9209
Publikováno v:
British Journal of Cancer
NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4497b6711831821642eb8a6f756f44
https://doi.org/10.1038/sj.bjc.6603414
https://doi.org/10.1038/sj.bjc.6603414
Publikováno v:
Anti-Cancer Drugs. 10:777-784
Four novel 4-substituted 5-nitrophthalimides (5-substituted-6-nitro-1,3-dihydro-isoindol-1,3-diones), 6, 7, 10 and 11, and the known 5 are prepared as analogs of the dinitrobenzamide prodrug CB 1954, 1, and considered as potential candidates for gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376f7cf0c5aa796cf0f0d9b297460a52
https://doi.org/10.1097/00001813-199909000-00011
https://doi.org/10.1097/00001813-199909000-00011
Publikováno v:
Human Gene Therapy. 8:709-717
The bystander effect is an important part of tumor kill using gene-directed enzyme prodrug therapy (GDEPT). Recently, we have described a novel enzyme prodrug system using bacterial nitroreductase and the prodrug CB1954 (NTR/CB1954). We demonstrate h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d99251959c92c0122daffbf0b09e517
https://doi.org/10.1089/hum.1997.8.6-709
https://doi.org/10.1089/hum.1997.8.6-709
Publikováno v:
European Journal of Cancer. 31:1373-1378
Despite extensive clinical trials, mortality from colon cancer has remained essentially unchanged since the 1950s. However, the increasing numbers of complete and partial responses seen in clinical trials suggest that colon cancer can be successfully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c466b36830585f231beafe5c41bcc6
https://doi.org/10.1016/0959-8049(95)00180-q
https://doi.org/10.1016/0959-8049(95)00180-q
Publikováno v:
Stroke. 24:1133-1139
In following patients initially recruited for a cross-sectional study of blood viscosity in ischemic cerebrovascular disease, it was noted that those having a low albumin-globulin ratio appeared to experience the majority of subsequent vascular event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f3ff04a20beb41ccdbae6fcbb9e567
https://doi.org/10.1161/01.str.24.8.1133
https://doi.org/10.1161/01.str.24.8.1133
Autor:
Gary Sexton, F. J. Nordt, Bruce M. Coull, Geoffrey V.F. Seaman, P. De Garmo, Nancy B. Beamer, R. J. Knox
Publikováno v:
Stroke. 22:162-168
The origin and significance of blood hyperviscosity in subjects with acute stroke has been controversial. It has been argued that viscous abnormalities simply reflect either elevated hematocrit or an acute-phase response to the stroke itself. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252de75e98f13de545b781957a70d9b3
https://doi.org/10.1161/01.str.22.2.162
https://doi.org/10.1161/01.str.22.2.162
Autor:
R J, Knox
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 2(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03c7be7f667dc59d57a4317b42924b13
https://pubmed.ncbi.nlm.nih.gov/11572666
https://pubmed.ncbi.nlm.nih.gov/11572666
Publikováno v:
Biochemical pharmacology. 62(4)
Evidence suggests that DT-diaphorase is involved in the activation and mechanism of cytotoxicity of the investigational indoloquinone anticancer drug EO9 under aerobic conditions. Data also implicate a role for other enzymes including NADPH: cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04677b51414e37f676d5c9bb75da0571
https://pubmed.ncbi.nlm.nih.gov/11448456
https://pubmed.ncbi.nlm.nih.gov/11448456
Autor:
G V, Seaman, R J, Knox
Publikováno v:
Electrophoresis. 22(3)
Process control is an increasingly important issue as life science companies world-wide strive for recognition of their manufacturing and product development quality measures according to International Standards Organization (ISO) or good manufacturi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fde2515f36228d8280d17adfa8a6e0f
https://pubmed.ncbi.nlm.nih.gov/11258742
https://pubmed.ncbi.nlm.nih.gov/11258742