SEC–MS as an Approach to Isolate and Directly Identifying Small Molecular GPCR–Ligands from Complex Mixtures Without Labeling

Autor: Hubertus Irth, A. Van Marie, Rob Leurs, C. F. De Jong, R. J. E. Derks, Henk Lingeman, Thomas Letzel

Publikováno v: Derks, R J E, Letzel, T, de Jong, C F, van Marie, A, Lingeman, H, Leurs, R & Irth, H 2006, ' SEC-MS as an approach to isolate and directly identifying small molecular GPCR-ligands from complex mixtures without labeling ', Chromatographia, vol. 64, no. 7-8, pp. 379-385 . https://doi.org/10.1365/s10337-006-0058-9
Chromatographia, 64(7-8), 379-385. Springer Vieweg

G protein coupled receptors (GPCRs) belong to the most successful targets in drug discovery. However, the development of assays with an appropriately labeled high affinity reporter compound is laborious. In the present study an MS-based binding assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6863c2983621ec60972814e97eef28a
https://doi.org/10.1365/s10337-006-0058-9