Zobrazeno 1 - 10 of 15 pro vyhledávání: '"R. J. Broersma"'
1
Synthesis of a 2,5-diaryloxazoline as a potential platelet-activating factor antagonist
Autor: Norton P. Peet, Eileen F. Heminger, Joseph P. Burkhart, R. J. Broersma
Publikováno v: Journal of Heterocyclic Chemistry. 31:419-423
2,5-Bis-(3,4,5-trimethoxyphenyl)-2-oxazoline (5, MDL 100,270) was desi- gned as a potential plateletactivating factor (PAF) antagonist on the basis of computer modeling comparison studies with known PAF antagonis- ts. An efficient, four-step synthesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e16c0075446b6a990ce12d14d24f8f5f
https://doi.org/10.1002/jhet.5570310229
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3
ChemInform Abstract: Synthesis of a 2,5-Diaryloxazoline as a Potential Platelet-Activating Factor Antagonist
Autor: Joseph P. Burkhart, Eileen F. Heminger, Norton P. Peet, R. J. Broersma
Publikováno v: ChemInform. 26
2,5-Bis-(3,4,5-trimethoxyphenyl)-2-oxazoline (5, MDL 100,270) was desi- gned as a potential plateletactivating factor (PAF) antagonist on the basis of computer modeling comparison studies with known PAF antagonis- ts. An efficient, four-step synthesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ab9a05cdf7f47b4d403c2a6f1a79da2
https://doi.org/10.1002/chin.199512163
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5
Antithrombotic activity of a novel C-terminal hirudin analog in experimental animals
Autor: R J, Broersma, L W, Kutcher, E F, Heminger, J L, Krstenansky, F N, Marshall
Publikováno v: Thrombosis and haemostasis. 65(4)
A synthetic hirudin55-65 C-terminal fragment analog was evaluated for anticoagulant activity and in models of experimental thrombosis in mice and rats. Intravenous injection caused dose-related inhibition of thrombin and anticoagulation in rat blood
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5cc0b5840ef365aa6574a86ca4c96264
https://pubmed.ncbi.nlm.nih.gov/1771625
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6
Development of MDL 28,050, a small stable antithrombin agent based on a functional domain of the leech protein, hirudin
Autor: J L, Krstenansky, R J, Broersma, T J, Owen, M H, Payne, M T, Yates, S J, Mao
Publikováno v: Thrombosis and haemostasis. 63(2)
MDL 28,050 is a decapeptide antithrombin agent that inhibits alpha-thrombin-induced fibrin clot formation by binding to a non-catalytic site on alpha-thrombin. It is the result of chemical and structural optimization of a functional domain of the lee
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a1eb5b8b699b1db1a704c873ca9eaa7
https://pubmed.ncbi.nlm.nih.gov/2363122
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8
Acidosis Induced Disseminated Intravascular Microthrombosis and its Dissolution by Streptokinase
Autor: Eberhard F. Mammen, R J Broersma, Bullemer Gd
Publikováno v: Thrombosis and Haemostasis. 24:055-067
SummaryTo elucidate the mechanisms triggering disseminated intravascular coagulation (DIC) in shock, acidosis was produced in dogs by intravenous infusions of lactic acid over a period of 4 h. As the pH of the blood dropped, the blood pressure increa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb746a0e9fe41a9432d69c017dddba2b
https://doi.org/10.1055/s-0038-1654211
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