Zobrazeno 1 - 10
of 25
pro vyhledávání: '"R. J. Boudreau"'
Autor:
A. Freshler, Aloke K. Dutta, R. H. Michelson, Simon M. N. Efange, R. P. Remmel, R. J. Boudreau
Publikováno v:
ChemInform. 22
Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d9e4b594ac665e2f6cc8c992508ecb
https://doi.org/10.1002/chin.199118165
https://doi.org/10.1002/chin.199118165
Autor:
R. J. Boudreau, S. M. N. Efange
Publikováno v:
Journal of Computer-Aided Molecular Design. 5:405-417
Nineteen analogs of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been used as probes to study the structural parameters that influence MAO-catalyzed oxidation. In this study, the efficiency of enzyme-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8866249a7b90612ea739f2d8e2cdf21
https://doi.org/10.1007/bf00125661
https://doi.org/10.1007/bf00125661
Autor:
R. J. Boudreau, R. P. Remmel, A. Freshler, R. H. Michelson, Simon M. N. Efange, Aloke K. Dutta
Publikováno v:
Journal of Medicinal Chemistry. 33:3133-3138
Eighteen analogues of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were synthesized and evaluated as substrates of monoamine oxidase. In general, the flexible analogues, characterized by the presence of a methylene (or ethylene) bridge between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcabbe39808589d890da9518d3761a5
https://doi.org/10.1021/jm00174a007
https://doi.org/10.1021/jm00174a007
Autor:
R J, Boudreau, J E, Mertz
Publikováno v:
Nuclear medicine and biology. 24(5)
Electronic structure calculations using the local-density functional method were shown to accurately reproduce the geometry of five oxo-Tc (V)-based radiopharmaceuticals containing a variety of donor ligands. Calculations were performed using the DGa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00dc97eb6a2ef4979e54800bdb8ef599
https://pubmed.ncbi.nlm.nih.gov/9290073
https://pubmed.ncbi.nlm.nih.gov/9290073
Autor:
Simon M. N. Efange, J.R. Thomas, J. Billings, R. H. Michelson, Hank Kung, Aloke K. Dutta, R. J. Boudreau
Publikováno v:
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 19(3)
Radioiodinated 2-hydroxy-3-(4-iodophenyl)-1-(4-phenylpiperidinyl)propane, 5 (4-HIPP), was synthesized and evaluated as a simple vesamicol-like radiotracer for mapping cholinergic pathways in the brain. Both enantiomers of 5 exhibit significant accumu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7561ae8de4045e51f7d15e35ec90424
https://pubmed.ncbi.nlm.nih.gov/1629023
https://pubmed.ncbi.nlm.nih.gov/1629023
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 32(8)
We compared 76 99mTc-DISIDA hepatobiliary studies with corresponding liver biopsies in 36 liver transplant patients to determine the histopathologic abnormalities that corresponded to scintigraphic abnormalities in uptake and excretion. Uptake was ju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::939bc1d70b750a01952e06894376e600
https://pubmed.ncbi.nlm.nih.gov/1869976
https://pubmed.ncbi.nlm.nih.gov/1869976
Publikováno v:
The Journal of laboratory and clinical medicine. 115(2)
To evaluate whether cyclosporine nephrotoxicity is progressive, glomerular filtration rate and renal plasma flow were determined by isotopic techniques in 24 cyclosporine-treated organ transplant recipients (12 heart, 1 pancreas, and 11 kidney recipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf7a0363dd32ca6b72167623c423c6c1
https://pubmed.ncbi.nlm.nih.gov/2405085
https://pubmed.ncbi.nlm.nih.gov/2405085
Publikováno v:
Investigative Radiology. 26:1153
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac7556530c2a43baf0c05cba3b6d07f6
https://doi.org/10.1097/00004424-199112000-00151
https://doi.org/10.1097/00004424-199112000-00151
Autor:
R. J. Boudreau, S. M.N. Efange
Publikováno v:
Investigative Radiology. 25:1350
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::921905df70b3df746a04aac7c2446b96
https://doi.org/10.1097/00004424-199012000-00036
https://doi.org/10.1097/00004424-199012000-00036
Publikováno v:
Biochemistry. 14:669-675
3',5'-CAMP phosphodiesterase was partially purified from bovine cerebral cortex. A heat-stable activating factor was separated from the enzyme by chromatography on DEAE-cellulose. The enzyme in crude ammonium sulfate fractions was stimulated by 5 mM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7145c64a8c045e940f742eeabbf9d74f
https://doi.org/10.1021/bi00675a004
https://doi.org/10.1021/bi00675a004