Výsledky vyhledávání - "R. J. Akhurst"

Akademický článek

Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients

Autor: L. Griffin, L. Ho, R. J. Akhurst, S. T. Arron, J. M. E. Boggs, P. Conlon, P. O’Kelly, A. E. Toland, E. H. Epstein, A. Balmain, B. C. Bastian, F. J. Moloney, G. M. Murphy, M. E. Laing

Publikováno v: Skin Health and Disease, Vol 2, Iss 2, Pp n/a-n/a (2022)

Abstract Background Renal transplant recipients (RTRs) are at increased risk of keratinocyte cancer (KC), especially cutaneous squamous cell carcinoma (cSCC). Previous studies identified a genetic variant of the Methylenetetrahydrofolate Reductase (M

Externí odkaz: https://doaj.org/article/96bb0e3338d646bf83ec68ce94af6bf5

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Akademický článek

α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Background Checkpoint blockade immunotherapy has improved metastatic cancer patient survival, but response rates remain low. There is an unmet need to identify mechanisms and tools to circumvent resistance. In human patients, responses to ch

Externí odkaz: https://doaj.org/article/4fe6933efb37461d998179c6fde2d077

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Genetic polymorphism in

Autor: L, Griffin, L, Ho, R J, Akhurst, S T, Arron, J M E, Boggs, P, Conlon, P, O'Kelly, A E, Toland, E H, Epstein, A, Balmain, B C, Bastian, F J, Moloney, G M, Murphy, M E, Laing

Publikováno v: Skin health and disease. 2(2)

Renal transplant recipients (RTRs) are at increased risk of keratinocyte cancer (KC), especially cutaneous squamous cell carcinoma (cSCC). Previous studies identified a genetic variant of theWe sought to find further genetic variation inGenotyping of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a251c644c6cb82977f577ae31f4883b0
https://pubmed.ncbi.nlm.nih.gov/35677930

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Fast and accurate identification of Xenorhabdus and Photorhabdus species by restriction analysis of PCR-amplified 16S rRNA genes

Autor: Noël Boemare, R J Akhurst, Anne Lanois, Brigitte Brunel, Alain Givaudan

Publikováno v: Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 1997, 63 (2), pp.574-580

Thirteen bacterial strains of Xenorhabdus and 14 strains of Photorhabdus originating from a wide range of geographical and nematode host sources were typed by analyzing 16S rRNA gene (rDNA) restriction patterns obtained after digestion of PCR-amplifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cb6e531e75ed7a82541a220421941a
https://doi.org/10.1128/aem.63.2.574-580.1997

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Genetic events and the role of TGF beta in epithelial tumour progression

Autor: R J, Akhurst, A, Balmain

Publikováno v: The Journal of pathology. 187(1)

The mouse skin model of chemical carcinogenesis has been very well characterized with respect to epigenetic changes, which occur during tumour cell initiation, promotion and progression. The use of transgenic and gene knock-out mice has contributed g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1579ad7107ff72c47265c9485db11cfb
https://pubmed.ncbi.nlm.nih.gov/10341708

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Growth Factor Disturbance

Autor: G. T. O’Neill, R. J. Akhurst

Publikováno v: Drug Toxicity in Embryonic Development I ISBN: 9783642644085

Growth factors are extracellular polypeptides that, by interaction with their corresponding transmembrane receptors, induce a cascade of intracellular signalling responses, which culminate in changes to the phenotype of the target cell (Nilsen-Hamilt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e213db4e0c3f55ccde6ab98bb5c10d9
https://doi.org/10.1007/978-3-642-60445-4_11

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Positive and negative growth control in multistage skin carcinogenesis

Autor: K, Brown, C J, Kemp, P A, Burns, A B, Stoler, D J, Fowlis, R J, Akhurst, A, Balmain

Publikováno v: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b0b9415454919007e3bcf1dbfe346c3
https://pubmed.ncbi.nlm.nih.gov/8356328

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The role of TGF beta in mouse development

Autor: R J, Akhurst, S A, Lehnert, D, Gatherer, E, Duffie

Publikováno v: Annals of the New York Academy of Sciences. 593

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ec18f4b288873017484c84e6eff63fc
https://pubmed.ncbi.nlm.nih.gov/1695826

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Erratum: Corrigendum: TGFβ signaling in health and disease

Autor: R J Akhurst

Publikováno v: Nature Genetics. 36:1024-1024

Nat. Genet. 36, 790 (2004). On page 791, in the second column, the second full sentence should begin, “Camurati-Engelmann syndrome, a bone overgrowth defect due to TGFB1 missense mutations...”.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a3b4f7110a85ba25f9af7d44615ecb4
https://doi.org/10.1038/ng0904-1024a

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