Zobrazeno 1 - 10 of 52 pro vyhledávání: '"R. J., Francis"'
2
Mycobacterium tuberculosis ESAT-6 is a leukocidin causing Ca2+ influx, necrosis and neutrophil extracellular trap formation
Autor: Rachel E. Butler, Graham R. Stewart, R J Francis
Publikováno v: Cell Death & Disease
Mycobacterium tuberculosis infection generates pulmonary granulomas that consist of a caseous, necrotic core surrounded by an ordered arrangement of macrophages, neutrophils and T cells. This inflammatory pathology is essential for disease transmissi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e72a428b5958bbc75b834e77351d3e
https://pubmed.ncbi.nlm.nih.gov/25321481
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3
Mycobacterium mimicking metastatic melanoma
Autor: R-W, Teh, K, Feeney, R J, Francis, M, Phillips, M J, Millward
Publikováno v: Internal medicine journal. 43(12)
We present three patients with lung nodules with an antecedent history of primary cutaneous melanoma or metastasis of melanoma to extrathoracic lymph nodes. Based on radiological findings, it was suspected that these patients had metastatic disease.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df2cf6ff93bd35e7dc78b9523e8347e9
https://pubmed.ncbi.nlm.nih.gov/24330366
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4
Initial and Steady State Pharmacokinetics of Cilazapril in Congestive Cardiac Failure
Autor: R. J. Francis, J. Steiner, J E Elstob, S. Rajaguru, D S Dymond, A. N. Brown, MN Wiseman
Publikováno v: Journal of Pharmacy and Pharmacology. 43:406-410
Twenty one patients with NYHA class II—III congestive heart failure received single ascending doses of 0·5, 1·25 and 2·5 mg cilazapril daily followed by the minimum effective dose for six weeks. Fifteen patients completed the study, but the data
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b8956d39195bf28689db86125b94be
https://doi.org/10.1111/j.2042-7158.1991.tb03498.x
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5
Pharmacokinetics of cilazapril during repeated oral dosing in healthy young volunteers
Autor: P. E. O. Williams, P. M. Dewland, S. Rajaguru, A. N. Brown, A. J. Bell, R. J. Francis
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 15:63-67
The pharmacokinetics of cilazapril and its active metabolite cilazaprilat in plasma were investigated in an open study of 13 healthy male volunteers, aged 18 to 43 years. One capsule containing 2.5 mg cilazapril was administered to each volunteer dai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f31198066e9a7d5e54ac98a7bb8d799
https://doi.org/10.1007/bf03190129
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6
Radiolabelling of glycosylated MFE-23::CPG2 fusion protein (MFECP1) with 99mTc for quantitation of tumour antibody-enzyme localisation in antibody-directed enzyme pro-drug therapy (ADEPT)
Autor: R. H. J. Begent, Surinder K. Sharma, RB Pedley, A J Green, S. J. Mather, R. Waibel, R. J. Francis, J Bhatia, KA Chester
Publikováno v: European journal of nuclear medicine and molecular imaging. 31(8)
MFECP1 is a glycosylated recombinant fusion protein composed of MFE-23, a high-affinity anti-carcinoembryonic antigen (CEA) single chain Fv (scFv), fused to the enzyme carboxypeptidase G2 (CPG2), and has been constructed for use in antibody-directed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635c5856bb4b6549dbbbdef62901d2c8
https://pubmed.ncbi.nlm.nih.gov/15029458
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7
A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours
Autor: L D Hope-Stone, D O'Malley, Hassan Shahbakhti, Surinder K. Sharma, E Tsiompanou, Ajw Hilson, Richard H. J. Begent, L Gumbrell, David C. Blakey, Daniel Hochhauser, K L Adamson, Janet Martin, A J Green, SD Webley, A Robbins, L Sena, R. J. Francis, Caroline J. Springer
Publikováno v: British Journal of Cancer
Antibody-directed enzyme prodrug therapy is a targeted therapy in which a prodrug is activated selectively at the tumour site by an enzyme, which has been targeted to the tumour by an antibody (antibody-enzyme conjugate). Previous clinical trials hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f37d304ba68b96192d5ba70661f029
https://pubmed.ncbi.nlm.nih.gov/12237768
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9
X-ray truncation rod analysis of the reversible temperature-dependent [001] surface structure of LaAlO3
Autor: R. J. Francis, Allan J. Jacobson, Simon C. Moss
Publikováno v: Physical Review B. 64
The surface structures, compositions, and terminations of ABO3oxides with the perovskite structure are of major importance due to their extensive use as substrates for thin film growth, in particular for the growth of superconducting films of materia
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99557b8027c5eeba881285ee28cded6d
https://doi.org/10.1103/physrevb.64.235425
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10
Critical pathways: not just for patients anymore
Autor: R J, Francis, C, Batsie
Publikováno v: Nursing management. 29(10)
Hospital managers initiate a nurse orientation program modeled after critical pathways. The structure allows them to assess nurses' competency while providing experience.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d14a5ea167a00497868c09a1ff679cf
https://pubmed.ncbi.nlm.nih.gov/9814311
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