Zobrazeno 1 - 10
of 75
pro vyhledávání: '"R. I. Nicholson"'
Autor:
K. J. Walker, R. I. Nicholson
The current article briefly reviews our data on the clinical and endocrinological efficacy of Zoladex (goserelin) and Nolvadex (tamoxifen) in the therapy of breast cancer in premenopausal women, and on the biological and antitumor properties of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d33fb4239d8c711dff11443e036390
https://doi.org/10.1159/000419643
https://doi.org/10.1159/000419643
Autor:
C Parker, R S Rampaul, S E Pinder, J A Bell, P M Wencyk, R W Blamey, R I Nicholson, J F R Robertson, I O Ellis
Publikováno v:
British Journal of Cancer
Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dd499f55dd315a51ef0233591ff59c
https://doi.org/10.1054/bjoc.2001.2178
https://doi.org/10.1054/bjoc.2001.2178
Autor:
J M W, Gee, A, Howell, W J, Gullick, C C, Benz, R L, Sutherland, R J, Santen, L-A, Martin, F, Ciardiello, W R, Miller, M, Dowsett, P, Barrett-Lee, J F R, Robertson, S R, Johnston, H E, Jones, A E, Wakeling, R, Duncan, R I, Nicholson
Anti-hormones (notably tamoxifen), chemotherapy and modern radiotherapeutic approaches are invaluable in the management of breast cancer, and collectively have contributed substantially to the improved survival in this disease. Moreover, there is pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::33fd787caa7ac4036efdf81f1251e916
http://hdl.handle.net/11591/227189
http://hdl.handle.net/11591/227189
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
In patients with estrogen receptor (ER)-negative disease or ER+ hormone-resistant disease, the dominant influence on tumor cell growth is growth factors, e.g., epidermal growth factor (EGF), heregulins, and insulin-like growth factors acting through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cebf0882fed4ef8a1d586d9132388dad
https://pubmed.ncbi.nlm.nih.gov/11916224
https://pubmed.ncbi.nlm.nih.gov/11916224
Autor:
A, Miremadi, S E, Pinder, A H S, Lee, J A, Bell, E C, Paish, P, Wencyk, C W, Elston, R I, Nicholson, R W, Blamey, J F, Robertson, I O, Ellis
Publikováno v:
Histopathology. 40(3)
Neuroendocrine differentiation has been detected, and its prognostic value studied, in a number of common human carcinomas. To date there are few detailed studies examining its relevance in breast carcinoma. In this study we evaluate the frequency an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b502640ad163dd87b3b4ad70b60ebb42
https://pubmed.ncbi.nlm.nih.gov/11895485
https://pubmed.ncbi.nlm.nih.gov/11895485
Autor:
J, Albanell, J, Codony-Servat, F, Rojo, J M, Del Campo, S, Sauleda, J, Anido, G, Raspall, J, Giralt, J, Roselló, R I, Nicholson, J, Mendelsohn, J, Baselga
Publikováno v:
Cancer research. 61(17)
The expression of the activated mitogen-activated kinases/extracellular signal-regulated kinases (ERKs) ERK1 and ERK2 was characterized in 101 humanhead and neck squamous carcinoma specimens. Activated ERK1/2were detected at different levels in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f97422edbe2fc3e98ce33643a6eb656f
https://pubmed.ncbi.nlm.nih.gov/11522647
https://pubmed.ncbi.nlm.nih.gov/11522647
Publikováno v:
International journal of cancer. 95(4)
It is believed that growth factor phosphorylation cascades interact closely with oestrogen receptor (ER) signaling to regulate breast cancer growth, and that alterations in these pathways may underlie resistance to anti-hormones such as tamoxifen. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bad909f735485fea3cb510b7f546d68
https://pubmed.ncbi.nlm.nih.gov/11400118
https://pubmed.ncbi.nlm.nih.gov/11400118
Publikováno v:
International journal of cancer. 89(2)
Sub-units and regulators of the activating protein-1(AP-1) complex have been implicated in breast-cancer biology, therapeutic response and prognosis. This study has immunocytochemically examined the impact of c-jun-protein activation on biological an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ce39c7a69b6fbd5bffbe71fa69dac8
https://pubmed.ncbi.nlm.nih.gov/10754497
https://pubmed.ncbi.nlm.nih.gov/10754497
Publikováno v:
International journal of cancer. 89(2)
We have examined the relative levels of oestrogen receptor beta (ERbeta) mRNA in 94 breast cancer specimens using a semi-quantitative RT-PCR procedure. We correlated its expression with ERalpha and various clinical, pathological and biochemical featu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56eaba13a629e4f3eaf1102e4b93fb27
https://pubmed.ncbi.nlm.nih.gov/10754501
https://pubmed.ncbi.nlm.nih.gov/10754501
Autor:
S S, Yip, A J, Crew, J M, Gee, R, Hui, R W, Blamey, J F, Robertson, R I, Nicholson, R L, Sutherland, R J, Daly
Publikováno v:
International journal of cancer. 88(3)
The protein tyrosine phosphatase SHP-1 is predominantly expressed in hemopoietic cell lineages, where its function is relatively well defined. However, its expression profile also extends to certain epithelial cell types. Furthermore, the negative re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::257768032938ae23343c85e868c08073
https://pubmed.ncbi.nlm.nih.gov/11054664
https://pubmed.ncbi.nlm.nih.gov/11054664