Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study

Autor: H. Ross-Adams, A.D. Lamb, M.J. Dunning, S. Halim, J. Lindberg, C.M. Massie, L.A. Egevad, R. Russell, A. Ramos-Montoya, S.L. Vowler, N.L. Sharma, J. Kay, H. Whitaker, J. Clark, R. Hurst, V.J. Gnanapragasam, N.C. Shah, A.Y. Warren, C.S. Cooper, A.G. Lynch, R. Stark, I.G. Mills, H. Grönberg, D.E. Neal

Publikováno v: EBioMedicine, Vol 2, Iss 9, Pp 1133-1144 (2015)

Background: Understanding the heterogeneous genotypes and phenotypes of prostate cancer is fundamental to improving the way we treat this disease. As yet, there are no validated descriptions of prostate cancer subgroups derived from integrated genomi

Externí odkaz: https://doaj.org/article/ecce61c7374c4e35b6c20633a6d57baa

Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study

Autor: John R Hurst, Ann Blandford, William Henley, Katherine Bradbury, Sarah Walker, Manuel Gomes, Paul Pfeffer, Henry Goodfellow, Chris Robson, David Sunkersing, Jiunn Wang

Publikováno v: BMJ Open, Vol 14, Iss 11 (2024)

Objectives To examine trajectories of functional limitations, fatigue, health-related quality of life (HRQL) and societal costs of patients referred to long COVID clinics.Design A population-based longitudinal cohort study using real-time user data.S

Externí odkaz: https://doaj.org/article/33b23043400146de9458f3fa27be12cb

1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study

Autor: Olivia C. Leavy, Richard J. Russell, Ewen M. Harrison, Nazir I. Lone, Steven Kerr, Annemarie B. Docherty, Aziz Sheikh, Matthew Richardson, Omer Elneima, Neil J. Greening, Victoria Claire Harris, Linzy Houchen-Wolloff, Hamish J.C. McAuley, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Raminder Aul, Paul Beirne, Charlotte E. Bolton, Jeremy S. Brown, Gourab Choudhury, Nawar Diar Bakerly, Nicholas Easom, Carlos Echevarria, Jonathan Fuld, Nick Hart, John R. Hurst, Mark Jones, Dhruv Parekh, Paul Pfeffer, Najib M. Rahman, Sarah Rowland-Jones, Ajay M. Shah, Dan G. Wootton, Caroline Jolley, A.A. Roger Thompson, Trudie Chalder, Melanie J. Davies, Anthony De Soyza, John R. Geddes, William Greenhalf, Simon Heller, Luke Howard, Joseph Jacob, R. Gisli Jenkins, Janet M. Lord, Will D-C. Man, Gerry P. McCann, Stefan Neubauer, Peter J.M. Openshaw, Joanna Porter, Matthew J. Rowland, Janet T. Scott, Malcolm G. Semple, Sally J. Singh, David Thomas, Mark Toshner, Keir Lewis, Liam G. Heaney, Andrew Briggs, Bang Zheng, Mathew Thorpe, Jennifer K. Quint, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise V. Wain, Christopher E. Brightling, Rachael A. Evans

Publikováno v: ERJ Open Research, Vol 10, Iss 5 (2024)

Background In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administratio

Externí odkaz: https://doaj.org/article/1d2fc6dbfe284fe4960b0e7810b277e4

Cardiovascular disease in Alpha 1 antitrypsin deficiency: an observational study assessing the role of neutrophil proteinase activity and the suitability of validated screening tools

Autor: E. Sapey, L. E. Crowley, R. G. Edgar, D. Griffiths, S. Samanta, H. Crisford, C. E. Bolton, J. R. Hurst, R. A. Stockley

Publikováno v: Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)

Abstract Background Alpha 1 Antitrypsin Deficiency (AATD) is a rare, inherited lung disease which shares features with Chronic Obstructive Pulmonary Disease (COPD) but has a greater burden of proteinase related tissue damage. These proteinases are as

Externí odkaz: https://doaj.org/article/5814b8a5090446efb43bb13c7ea46ffc

Core outcome sets for trials of interventions to prevent and to treat multimorbidity in adults in low and middle-income countries: the COSMOS study

Autor: Najma Siddiqi, Josefien van Olmen, Meena Daivadanam, Naveed Ahmed, Abdul Kuddus, John R Hurst, Rumana Huque, Bruno P Nunes, Devarsetty Praveen, Rajesh Vedanthan, Louise Rose, Naomi S Levitt, Gina Agarwal, Sailesh Mohan, Adewale L Oyeyemi, Patricio Lopez-Jaramillo, Marianna Purgato, Rachel Churchill, Corrado Barbui, Kamran Siddiqi, Sanjib Kumar Sharma, Judy M Wright, Helal Uddin Ahmed, Lijing L Yan, Jamie Kirkham, Laura Downey, Phuong Bich Tran, Elizabeth Shayo, Ana Cristina García-Ulloa, Carlos Alberto Aguilar-Salinas, Gerardo A Zavala, Faiza Aslam, Cecilia Anza-Ramirez, Anthony Danso-Appiah, Khaleda Islam, Abdou K Sillah, Saidur R Mashreky, Asiful Haidar Chowdhury, Ram Krishna Chandyo, Jessica Hanae Zafra-Tanaka, Rakesh Singh, Juan Jaime Miranda, Arun Kumar Sharma, Saima Afaq, Kamrun Nahar Koly, Ruth Verhey, Sushama Kanan, Rusham Zahra Rana, Oscar Flores-Flores, Rufus Olusola Akinyemi, Job van Boven, Santa Kumar Das, Rubab Ayesha, Jan R Boehnke, Aishwarya Lakshmi Vidyasagaran, Mehreen Riaz Faisal, Kingsley Akinroye, Syed Rahmat Ali, Rabeea Aman, Koralagamage Kavindu Appuhamy, Se-Sergio Baldew, Sandro Rogerio Rodrigues Batista, María del Carmen Caamaño, Noemia Teixeira de Siqueira-Filha, Darwin Del Castillo Fernández, Olga P García, Richard IG Holt, Johnblack K Kabukye, Humaira Khalid, Joseph Senyo Kwashie, Krishna Prasad Muliyala, Qirat Naz, Augustine Nonso Odili, Niels Victor Pacheco-Barrios, Dolores Ronquillo, Pervaiz Tufail, Eleonora P Uphoff, Yang William Zhao, Jibril Abdulmalik, Anoshmita Adhikary, Isaac Kwaku Adu, Christel Antonius-Smits, Anas Ashraful, Camilla Cadorin, Alyssa Chase, Daniella Eiloof, Tonatiuh Barrientos Gutierrez, Najma Hayat, Victoria Cavero Huapaya, Daniel Mograbi, Anum Naz, Zara Nisar, Adesola Odole, Obehi H Okojie, Abdrahamane Ouedraogo, Claudia Bambs Sandoval, Alejandro Zevallos-Morales

Publikováno v: BMJ Global Health, Vol 9, Iss 8 (2024)

Introduction The burden of multimorbidity is recognised increasingly in low- and middle-income countries (LMICs), creating a strong emphasis on the need for effective evidence-based interventions. Core outcome sets (COS) appropriate for the study of

Externí odkaz: https://doaj.org/article/0250578f95ea4babb231bb8659b3d043