Zobrazeno 1 - 10
of 49
pro vyhledávání: '"R. Hurkmans"'
Autor:
M. Blöschl, B. L. McGlynn, H. Borga, L. Nandagiri, Helge Bormann, R. Uijlenhoet, T. Wagener, R. Hurkmans, Jürgen Komma
Publikováno v:
Runoff Prediction in Ungauged Basins: Synthesis Across Processes, Places and Scales
Runoff Prediction in Ungauged Basins: Synthesis Across Processes, Places and Scales. Cambridge University Press
Runoff Prediction in Ungauged Basins: Synthesis Across Processes, Places and Scales. Cambridge University Press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ecb9b983109d59c787113ea68bd779
http://hdl.handle.net/11577/3042734
http://hdl.handle.net/11577/3042734
Autor:
R Hurkmans, M. Bockx, W. Lauwers, D. Van Dyck, K. Lavrijsen, L. Le Jeune, J. Van Houdt, J. Heykants, Willem Meuldermans, J. Hendrickx
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(7)
1. The biotransformation of 3H-flunarizine ((E)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride, FLUN) was studied in subcellular liver fractions (microsomes and 12,000 g fraction) and in suspensions or primary cell cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29d2a4cd24e8a2379f7a6b05563c3e5
https://pubmed.ncbi.nlm.nih.gov/1455902
https://pubmed.ncbi.nlm.nih.gov/1455902
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 6:49-60
The excretion and metabolism of the novel gastrokinetic and antinauseant drug domperidone were studied after oral administration of the 14C-labelled compound to rats, dogs and man, and after intravenous administration to rats and dogs. Excretion of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15afd713b2578ef824911adddee297b
https://doi.org/10.1007/bf03189515
https://doi.org/10.1007/bf03189515
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 1:35-40
Mebendazole-14C was incubated with the 10,000g and 100,000g supernatant fractions and the microsomal fractions of pig, rat and dog liver. The metabolism progressed remarkably slowly. The metabolites were separated by extraction and thin-layer chromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eacf9a70df9668d204da0cdfde621673
https://doi.org/10.1007/bf03192277
https://doi.org/10.1007/bf03192277
Autor:
W, Meuldermans, J, Hendrickx, W, Lauwers, E, Swysen, R, Hurkmans, F, Knaeps, R, Woestenborghs, J, Heykants
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 12(6)
The excretion and biotransformation of ketanserin, a novel serotonin S2-receptor blocking agent used in hypertension and related diseases, were studied after single po (1 or 10 mg/kg) and iv (2.5 mg/kg) administration in rats and dogs, using two diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a36d0e210f8a2cdf15891ed6a2665127
https://pubmed.ncbi.nlm.nih.gov/6150829
https://pubmed.ncbi.nlm.nih.gov/6150829
Autor:
W, Meuldermans, J, Hendrickx, R, Hurkmans, E, Swysen, R, Woestenborghs, W, Lauwers, J, Heykants
Publikováno v:
Arzneimittel-Forschung. 33(8)
The excretion and metabolism of (E)-1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride (flunarizine hydrochloride, R 14 950, Sibelium) were studied after single oral doses in rats and dogs, using tritium-labelled as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eec5edb9c5a9943513a4958f78204c6f
https://pubmed.ncbi.nlm.nih.gov/6685491
https://pubmed.ncbi.nlm.nih.gov/6685491
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 8(4)
After p.o. or i.v. administration of 3H-lorcainide, excretion of the radioactivity was almost complete within four days. In rats and dogs, about 35% of the dose was excreted in the urine and about 60% in the faeces. However, in humans, 62% was excret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b16246fd1f46135bd0fac4b5079ddf5
https://pubmed.ncbi.nlm.nih.gov/6673971
https://pubmed.ncbi.nlm.nih.gov/6673971
Autor:
W, Meuldermans, J, Hendrickx, W, Lauwers, R, Hurkmans, E, Mostmans, E, Swysen, J, Bracke, A, Knaeps, J, Heykants
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 16(3)
The excretion and biotransformation of cisapride, a novel gastrokinetic drug, were studied after single (10, 40, and 160 mg/kg) and repeated (10 mg/kg/day) po administration to rats, using three different radiolabels. In fasted rats, cisapride was ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30519e7205cb3bbbc04c1dea9c064cc5
https://pubmed.ncbi.nlm.nih.gov/2900733
https://pubmed.ncbi.nlm.nih.gov/2900733
Autor:
W, Meuldermans, J, Hendrickx, W, Lauwers, R, Hurkmans, E, Swysen, J, Thijssen, P, Timmerman, R, Woestenborghs, J, Heykants
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(6)
The excretion and biotransformation of alfentanil (ALF) and sufentanil (SUF), two recent analogues of the synthetic opioid fentanyl, were studied after single iv administration of the tritium-labeled drugs in male rats and dogs. The drugs were almost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::55d5a641713baa7b2bbab4e934b4e734
https://pubmed.ncbi.nlm.nih.gov/2893720
https://pubmed.ncbi.nlm.nih.gov/2893720
Autor:
Willem Meuldermans, J. Hendrickx, R Hurkmans, F. Knaeps, K. Lavrijsen, J. Van Houdt, J. Heykants, W. Lauwers
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 18(2)
1. The biotransformation of 3H-alfentanil was studied using suspension cultures of isolated hepatocytes of male and female rats and of dogs. 2. In hepatocytes of the male rat, alfentanil was readily metabolized, following linear Michaelis-Menten kine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e983bd1b6f0e5871860a5c5c6fe9e1fa
https://pubmed.ncbi.nlm.nih.gov/3131971
https://pubmed.ncbi.nlm.nih.gov/3131971