Northeast Atlantic breakup volcanism and consequences for Paleogene climate change – MagellanPlus Workshop report

Autor: C. Berndt, S. Planke, D. Teagle, R. Huismans, T. Torsvik, J. Frieling, M. T. Jones, D. A. Jerram, C. Tegner, J. I. Faleide, H. Coxall, W.-L. Hong

Publikováno v: Scientific Drilling, Vol 26, Pp 69-85 (2019)

The northeast Atlantic encompasses archetypal examples of volcanic rifted margins. Twenty-five years after the last ODP (Ocean Drilling Program) leg on these volcanic margins, the reasons for excess melting are still disputed with at least three comp

Externí odkaz: https://doaj.org/article/d0efd8bdc1d242c1b78a4635511cb7cb

FLT3 internal tandem duplication in 234 children with acute myeloid leukemia

Autor: Martin Zimmermann, Jerald P. Radich, Leonhard Munske, Soheil Meshinchi, Dirk Reinhardt, Karel Hählen, Frank Griesinger, Rob Pieters, Jochen Harbott, Christian M. Zwaan, D. R. Huismans, Gertjan J.L. Kaspers, Martina Podleschny, Ursula Creutzig, Anjo J.P. Veerman

Publikováno v: Blood, 102(7), 2387-2394. American Society of Hematology
Zwaan, C M, Meshinchi, S, Radich, J P, Veerman, A J P, Huismans, D R, Munske, L, Podleschny, M, Hählen, K, Pieters, R, Zimmermann, M, Reinhardt, D, Harbott, J, Creutzig, U, Kaspers, G J L & Griesinger, F 2003, ' FLT3 internal tandem duplication in 234 children with acute myeloid leukemia : Prognostic significance and relation to cellular drug resistance ', Blood, vol. 102, no. 7, pp. 2387-2394 . https://doi.org/10.1182/blood-2002-12-3627
Blood, 102, 2387-2394. American Society of Hematology

FLT3 is a receptor tyrosine kinase involved in the proliferation and differentiation of hematopoietic stem cells. FLT3 internal tandem duplications (FLT3/ITDs) are reported in acute myeloid leukemia (AML) and predict poor clinical outcome. We found F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99db663ec543ecdc20ba6b1c9c1e1305
https://doi.org/10.1182/blood-2002-12-3627

In vitro drug resistance profiles of adult versus childhood acute lymphoblastic leukaemia

Autor: D. R. Huismans, Rob Pieters, Maruisz Wysocki, Anjo J.P. Veerman, Jan Styczyński, Gerrit Jan Schuurhuis

Publikováno v: British Journal of Haematology. 110:813-818

The difference in the current cure rates between adult and childhood acute lymphoblastic leukaemia (ALL) may be caused by differences in drug resistance. Earlier studies showed that in vitro cellular drug resistance is a strong independent adverse ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56eb6370492dbf8304e5ed3b6b6c2741
https://doi.org/10.1046/j.1365-2141.2000.02211.x

In vitro anthracycline cross-resistance pattern in childhood acute lymphoblastic leukaemia

Autor: A H Loonen, A. J. P. Veerman, E. Klumper, M. L. Den Boer, D. R. Huismans, Rob Pieters

Publikováno v: British Journal of Cancer

Daunorubicin (DNR) is a major front-line drug in the treatment of childhood acute lymphoblastic leukaemia (ALL). Previously, we showed that in vitro resistance to DNR at diagnosis is related to a poor long-term clinical outcome in childhood ALL and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aa557fd67b2e7f7f08a63091645259
https://doi.org/10.1038/bjc.1995.231

Cytotoxic Effects of Vitamin A in Combination with Vincristine, Daunorubicin and 6-Thioguanine upon Cells from Lymphoblastic Leukemic Patients

Autor: Rob Pieters, A H Loonen, D. R. Huismans, Karel Hählen, Anjo J.P. Veerman

Publikováno v: Japanese Journal of Cancer Research : Gann

We studied whether isotretinoin potentiated the effects of vincristine (VCR), daunorubicin (DNR), and 6-thioguanine (6-TG) against cells obtained from 24 patients with acute lymphoblastic leukemia (ALL). Treatment with 5 micrograms/ml isotretinoin al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c76226f2ea656accee6867e900e16e9
https://doi.org/10.1111/j.1349-7006.1991.tb01942.x