Výsledky vyhledávání

HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers

Autor: B Wizel, R Houghten, P Church, J A Tine, D E Lanar, D M Gordon, W R Ballou, A Sette, S L Hoffman

Publikováno v: The Journal of Immunology. 155:766-775

CD8+ CTL specific for the Plasmodium yoelii sporozoite surface protein 2 (PySSP2) protect mice against malaria. For this reason, vaccines designed to induce CTL against P. falciparum SSP2 (PfSSP2) are under development. Optimal development of PfSSP2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f03a909f99462c2472fcf7a06fb2d122
https://doi.org/10.4049/jimmunol.155.2.766

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Immunization with soluble protein-pulsed spleen cells induces class I-restricted cytotoxic T lymphocytes that recognize immunodominant epitopic peptides from Plasmodium falciparum and HIV-1

Autor: A Hosmalin, S Kumar, D Barnd, R Houghten, G E Smith, S H Hughes, J A Berzofsky

Publikováno v: The Journal of Immunology. 149:1311-1318

CTL lines specific for two different proteins derived from the human pathogens, Plasmodium falciparum (malaria) circumsporozoite protein and HIV-1 reverse transcriptase, were obtained by immunizing mice with protein-pulsed syngeneic spleen cells. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3851177fe12af18ff5d5272cc3a163fb
https://doi.org/10.4049/jimmunol.149.4.1311

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Elucidation of discontinuous linear determinants in peptides

Autor: J R Appel, C Pinilla, H Niman, R Houghten

Publikováno v: The Journal of Immunology. 144:976-983

Synthetic peptides, made by the method of simultaneous multiple peptide synthesis, were coupled to the protein carrier keyhole limpet hemocyanin and used to raise mAb. Omission and substitution analogs of the original peptides were tested by ELISA to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a1e40ef61cb8e2e42798d68e74fe7e2
https://doi.org/10.4049/jimmunol.144.3.976

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Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology

Autor: B, Hemmer, M, Vergelli, B, Gran, N, Ling, P, Conlon, C, Pinilla, R, Houghten, H F, McFarland, R, Martin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(8)

The potential of CD4+ T cells for cross-recognition of self and foreign Ags has important implications for the understanding of thymic selection, lymphocyte survival, and the occurrence of autoimmune diseases. Here, we define the extensive flexibilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75e2900dd766a7cf64ce33d5914e2e9a
https://pubmed.ncbi.nlm.nih.gov/9558061

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Synthetic compound peptide simulating antigenicity of conformation-dependent autoepitope

Autor: Y, Muro, W M, Tsai, R, Houghten, E M, Tan

Publikováno v: The Journal of biological chemistry. 269(28)

Proliferating cell nuclear antigen (PCNA), also known as auxiliary protein of DNA polymerase delta, is involved in DNA replication and repair. Certain patients with systemic lupus erythematosus (lupus) produce autoantibodies to PCNA and the autoantib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2921fa85e588dde8a23285325d1d6c1e
https://pubmed.ncbi.nlm.nih.gov/7518436

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An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans

Autor: T Akatsuka, C Wychowski, S M Feinstone, J A Berzofsky, C D Pendleton, Mutsunori Shirai, R Houghten, Mikio Nishioka, H Okada

Publikováno v: Journal of virology. 68(5)

Several cytotoxic T-lymphocyte (CTL) epitopes have been defined in hepatitis C virus (HCV) proteins. CTL may play an important role in the control of infection by HCV. Here, we identify a highly conserved antigenic site in the HCV core recognized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fe0192c76c113dd1c2ebf742db7aeb
https://pubmed.ncbi.nlm.nih.gov/7512163

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Analysis of the epitopes of proliferating cell nuclear antigen recognized by monoclonal antibodies

Autor: G, Roos, G, Landberg, J P, Huff, R, Houghten, Y, Takasaki, E M, Tan

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 68(2)

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA) are increasingly used for evaluation of cell proliferation especially in diagnostic pathology. To understand the different staining characteristics of such antibodies, we found it imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8a8e8083cdc86a1f89e0fcb1510e26c
https://pubmed.ncbi.nlm.nih.gov/7680082

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Induction of cytotoxic T cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein

Autor: Toshitaka Akatsuka, Mutsunori Shirai, R Houghten, C D Pendleton, S M Feinstone, C Wychowski, Jay A. Berzofsky, K Mihalik

Publikováno v: Journal of virology. 66(7)

Cytotoxic T lymphocytes (CTL) have been found to mediate protection in vivo against certain virus infections. CTL also may play an important role in control of infection by hepatitis C virus (HCV), but no CTL epitopes have yet been defined in any HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd0d799712219a772b3e880db7639d6
https://pubmed.ncbi.nlm.nih.gov/1376366

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