Zobrazeno 1 - 10
of 377
pro vyhledávání: '"R. Horuk"'
Autor:
M. Halks-Miller, P. Mäding, Joerg Steinbach, R. Horuk, F. Füchtner, R. Mohan, M. Friebe, Christoph Stephan Hilger, B. Johannsen
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 49:253-262
The synthesis of 1-(5-chloro-2-{2-[(2R)-4-(4-[18F]fluorobenzyl)-2-methylpiperazin-1-yl]-2-oxoethoxy}phenyl)urea ([18F]4), a potent nonpeptide CCR1 antagonist, is described as a module-assisted two-step one-pot procedure. The final product was obtaine
Autor:
V. Snieckus, N. J. Geach, G. P. Randall, C. J. Winfield, A. Studer, A. C. Spivey, T. Jones, C. Noban, G. J. Ellames, A. Kohler, H. Wadsworth, J. Rieke-Zapp, S. Stone-Elander, J. Goehl, B. Perry, J. Windels, M. H. Marx, J. Krüger, B. Manmontri, G. Fels, F. Wüst, T. Kniess, R. Bergmann, P. Mäding, F. Füchtner, C. S. Hilger, M. Halks-Miller, R. Horuk, L. Matei, C. Postolache, V. Fugaru, E. Condac, A. Dinischiotu, M. Costache, J. Atzrodt, V. Derdau
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 47:1035-1060
V Snieckus [Queen's University, Canada]—The Directed Ortho Metalation—Cross Coupling Symbiosis in Aromatic Synthesis. N Geach, GP Randall, CJ Winfield [Scynexis, UK]—Isotopically Labelled 4-Formylimidazole. A Studer [Marburg University, Germany
Autor:
J, Hesselgesser, M, Liang, J, Hoxie, M, Greenberg, L F, Brass, M J, Orsini, D, Taub, R, Horuk
Publikováno v:
The Journal of Immunology. 160:877-883
The CXCR4 chemokine receptor has been shown to respond to the C-X-C chemokine stromal-derived factor (SDF-1) and has recently been shown to be an important coreceptor for HIV-1 infection. In the present paper we have tested a number of human T lympho
Autor:
R Horuk, A W Martin, Z Wang, L Schweitzer, A Gerassimides, H Guo, Z Lu, J Hesselgesser, H D Perez, J Kim, J Parker, T J Hadley, S C Peiper
Publikováno v:
The Journal of Immunology. 158:2882-2890
IL-8 is expressed by activated and neoplastic astrocytes and enhances the survival of hippocampal neurons in vitro. Since mRNA encoding chemokine receptors have been demonstrated in brain, the expression of chemokine receptors by specific cell types
Publikováno v:
The Journal of Experimental Medicine
Plasmodium vivax and the related simian malarial parasite P. knowlesi use the Duffy blood group antigen as a receptor to invade human erythrocytes and region II of the parasite ligands for binding to this erythrocyte receptor. Here, we identify the p
Autor:
Terence J. Hadley, A. W. Martin, R. Horuk, J. Hesselgesser, Zhao-Hai Lu, Stephen C. Peiper, Zi-Xuan Wang
Publikováno v:
Journal of Leukocyte Biology. 59:29-38
The Duffy antigen receptor for chemokines (DARC) is expressed in human erythrocytes and on endothelial cells lining postcapillary venules in kidney and spleen. DARC is a promiscuous chemokine receptor and a binding protein for the malarial parasite P
Autor:
Stephen C. Peiper, K. Wasniowska, Zhao-Hai Lu, R. Horuk, J. Hesselgesser, A. W. Martin, Terence J. Hadley
Publikováno v:
Journal of Clinical Investigation. 94:985-991
The human erythrocyte chemokine receptor has recently been shown to be identical to the Duffy blood group antigen and is expressed in multiple organs, including kidney. Here we have examined the molecular properties of the renal isoform. Immunoblot a
Publikováno v:
Journal of Biological Chemistry. 269:7835-7838
The human malarial parasite Plasmodium vivax invades erythrocytes by binding to a cell surface protein identified as the Duffy blood group antigen. The molecular properties of the Duffy antigen, which was recently cloned, are very similar to those of
Publikováno v:
Ernst Schering Foundation Symposium Proceedings ISBN: 9783540489818
GPCRs: From Deorphanization to Lead Structure Identification
GPCRs: From Deorphanization to Lead Structure Identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf8e54d5ea2da2296c4052f08fae99a
https://doi.org/10.1007/978-3-540-48982-5
https://doi.org/10.1007/978-3-540-48982-5
Publikováno v:
IDrugs : the investigational drugs journal. 2(5)
Chemokines belong to a large family of chemoattractant molecules involved in the directed migration of immune cells. They achieve their cellular effects by direct interaction with cell surface receptors. One such chemokine receptor is CCR1 which is p