Zobrazeno 1 - 10
of 54
pro vyhledávání: '"R. Herdy"'
Autor:
Yongsung Kim, Xinde Zheng, Zoya Ansari, Mark C. Bunnell, Joseph R. Herdy, Larissa Traxler, Hyungjun Lee, Apua C.M. Paquola, Chrysanthi Blithikioti, Manching Ku, Johannes C.M. Schlachetzki, Jürgen Winkler, Frank Edenhofer, Christopher K. Glass, Andres A. Paucar, Baptiste N. Jaeger, Son Pham, Leah Boyer, Benjamin C. Campbell, Tony Hunter, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2550-2558 (2018)
Mitochondria are a major target for aging and are instrumental in the age-dependent deterioration of the human brain, but studying mitochondria in aging human neurons has been challenging. Direct fibroblast-to-induced neuron (iN) conversion yields fu
Externí odkaz:
https://doaj.org/article/745b25dfd2684290864d22273782c442
Autor:
Joseph R. Herdy
Publikováno v:
AIAA SCITECH 2023 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eb6c886877aa9ae6163444b763e1e6e
https://doi.org/10.2514/6.2023-0202
https://doi.org/10.2514/6.2023-0202
Autor:
Joseph R. Herdy, Larissa Traxler, Ravi K. Agarwal, Lukas Karbacher, Johannes C.M. Schlachetzki, Lena Boehnke, Dina Zangwill, Doug Galasko, Christopher K. Glass, Jerome Mertens, Fred H. Gage
Publikováno v:
Cell Stem Cell
The concept of senescence as a phenomenon limited to proliferating cells has been challenged by growing evidence of senescence-like features in terminally differentiated cells, including neurons. The persistence of senescent cells late in life is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9086903782b873f3bf38da30838300c7
https://europepmc.org/articles/PMC10093780/
https://europepmc.org/articles/PMC10093780/
Autor:
Joseph R. Herdy, Rhonda Stevenson
Publikováno v:
ASCEND 2022.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df382e8ed6f560020e89645e44d3dbbb
https://doi.org/10.2514/6.2022-4337
https://doi.org/10.2514/6.2022-4337
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006103 (2016)
The sea lamprey (Petromyzon marinus) represents one of the few vertebrate species known to undergo large-scale programmatic elimination of genomic DNA over the course of its normal development. Programmed genome rearrangements (PGRs) result in the re
Externí odkaz:
https://doaj.org/article/cb326d0a10454b01acd6d4e454726bff
Autor:
Joseph R. Herdy
Publikováno v:
AIAA SCITECH 2022 Forum.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe93bcda3164cd761954628128a80bd3
https://doi.org/10.2514/6.2022-1732
https://doi.org/10.2514/6.2022-1732
Autor:
Larissa Traxler, Joseph R. Herdy, Davide Stefanoni, Sophie Eichhorner, Silvia Pelucchi, Attila Szücs, Alice Santagostino, Yongsung Kim, Ravi K. Agarwal, Johannes C.M. Schlachetzki, Christopher K. Glass, Jessica Lagerwall, Douglas Galasko, Fred H. Gage, Angelo D’Alessandro, Jerome Mertens
Publikováno v:
Cell Metabolism
The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a metabolic switch to aerobic glycolysis in AD iNs. Pathological is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6faef33af13e5700cdac054f61475e1
https://doi.org/10.1016/j.cmet.2022.07.014
https://doi.org/10.1016/j.cmet.2022.07.014
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab56470358e690f442ac6be149dcb9
https://doi.org/10.1073/pnas.2022751118
https://doi.org/10.1073/pnas.2022751118
Autor:
Ona Bloom, Jennifer R. Morgan, Courtney K. M. Waterbury, Angelos Papatheodorou, Joseph D. Buxbaum, Stephanie A. Bryant, Paige E. Herman, J. Joshua Smith, Anthony A. Arcese, Joseph R. Herdy
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports
Scientific Reports
In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic connections, and consequently function. Unlike mammals, lampreys are vertebrates that undergo spontaneous regeneration and achieve functional recovery after SCI. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67cf42773b9f1b495c66848cf89400e
http://link.springer.com/article/10.1038/s41598-017-18757-1
http://link.springer.com/article/10.1038/s41598-017-18757-1