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Akademický článek

Phage Resistance Accompanies Reduced Fitness of Uropathogenic Escherichia coli in the Urinary Environment

Autor: Jacob J. Zulk, Justin R. Clark, Samantha Ottinger, Mallory B. Ballard, Marlyd E. Mejia, Vicki Mercado-Evans, Emmaline R. Heckmann, Belkys C. Sanchez, Barbara W. Trautner, Anthony W. Maresso, Kathryn A. Patras

Publikováno v: mSphere, Vol 7, Iss 4 (2022)

ABSTRACT Urinary tract infection (UTI) is among the most common infections treated worldwide each year and is caused primarily by uropathogenic Escherichia coli (UPEC). Rising rates of antibiotic resistance among uropathogens have spurred a considera

Externí odkaz: https://doaj.org/article/6a92d0cf7da14d0d80830753163d2b33

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Akademický článek

Development of Phage Cocktails to Treat E. coli Catheter-Associated Urinary Tract Infection and Associated Biofilms

Autor: Belkys C. Sanchez, Emmaline R. Heckmann, Sabrina I. Green, Justin R. Clark, Heidi B. Kaplan, Robert F. Ramig, Kenneth L. Muldrew, Casey Hines-Munson, Felicia Skelton, Barbara W. Trautner, Anthony W. Maresso

Publikováno v: Frontiers in Microbiology, Vol 13 (2022)

High rates of antimicrobial resistance and formation of biofilms makes treatment of Escherichia coli catheter-associated urinary tract infections (CAUTI) particularly challenging. CAUTI affect 1 million patients per year in the United States and are

Externí odkaz: https://doaj.org/article/6e03aa9e8ea241e48a00b4d19c1c51c0

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Akademický článek

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Akademický článek

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Tailored Antibacterials and Innovative Laboratories for Phage (Φ) Research: Personalized Infectious Disease Medicine for the Most Vulnerable At-Risk Patients

Autor: Justin R. Clark, Emmaline R Heckmann, Anthony W. Maresso, Carmen Gu Liu, Robert F. Ramig, Barbara W. Trautner, Austen Terwilliger, Keiko C. Salazar, Haroldo Hernandez Santos, Sabrina I. Green

Publikováno v: Phage (New Rochelle)

Mutation is the most powerful driver of change for life on Earth. Pathogenic bacteria utilize mutation as a means to survive strong live-die selective pressures generated by chemical antibiotics. As such, the traditional drug-making pipeline, charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2f37af881225b9ca3b04a52a889526
https://doi.org/10.1089/phage.2020.0007

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Phage resistance accompanies reduced fitness of uropathogenic E. coli in the urinary environment

Urinary tract infections (UTIs) are among the most common infections treated worldwide each year and are primarily caused by uropathogenic E. coli (UPEC). Rising rates of antibiotic resistance among uropathogens have spurred consideration of alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bfa8f7a1d81581e6f38542ddaa54386
https://doi.org/10.1101/2021.12.02.471000

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