Zobrazeno 1 - 10
of 76
pro vyhledávání: '"R. Hannuniemi"'
Autor:
K. Kippo, R. Hannuniemi, R. Sellman, Vuokko Kovanen, L. Laurén, T. Österman, T Virtamo, H. Ikävalko
Publikováno v:
Bone. 17:533-542
The present study was carried out to investigate the ability of clodronate to inhibit ovariectomy-induced bone loss and increased bone turnover in rats. Estradiol was administered as a reference compound. Seventy Sprague-Dawley rats were ovariectomiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcb248c73cede734874b0da7a5fb4db
https://doi.org/10.1016/8756-3282(95)00388-6
https://doi.org/10.1016/8756-3282(95)00388-6
Publikováno v:
Inflammation Research. 44:258-263
The collagen-induced arthritis model in rats was used to study the effect of disodium clodronate on inflammation and destruction of tarsal, metatarsal, and interphalangeal bones and joints. Female DA rats were immunized with heterologous type II coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc3d50d583db3c810800e3ab36f0bf4
https://doi.org/10.1007/bf01782979
https://doi.org/10.1007/bf01782979
Autor:
Kleimola T, R. Hannuniemi, Tapani A. Pakkanen, K. Kippo, Lindroos J, L. Laurén, J.-P. Björkroth, Juhakoski A, Hanhijärvi H, Esko Pohjala
Publikováno v:
Journal of Medicinal Chemistry. 34:2338-2343
Comparative molecular field analysis (CoMFA) has been used as a three-dimensional quantitative structure-activity relationship (QSAR) method to correlate three different types of biological activity data with physicochemical properties of some clodro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebce2bdf640b439462e895c79e4f7752
https://doi.org/10.1021/jm00112a004
https://doi.org/10.1021/jm00112a004
Autor:
P. Isaksson, R. Sellman, H.K. Väänänen, P. Kuurtamo, T. Österman, R. Hannuniemi, L. Laurén, Z. Peng, T Virtamo, K. Kippo
Publikováno v:
Bone. 23(4)
The ability of clodronate to prevent bone loss and weakening of bone strength was studied in adult rats with established osteopenia. Six-month-old female Sprague Dawley rats were randomized into 13 groups. One group was killed at the start of the stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1827bb99c61e03202f1f51a3d01461
https://pubmed.ncbi.nlm.nih.gov/9763145
https://pubmed.ncbi.nlm.nih.gov/9763145
Autor:
T, Osterman, L, Laurén, P, Kuurtamo, R, Hannuniemi, P, Isaksson, K, Kippo, Z, Peng, H K, Väänänen, R, Sellman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(1)
The effects of clodronate administered p.o. on bone mineral density (BMD), bone geometry and strength of bone were investigated in 6-month-old ovariectomized rats. Sixty Sprague-Dawley rats were randomized into four groups. Three groups were ovariect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43002554d598648cce51a78148272d43
https://pubmed.ncbi.nlm.nih.gov/9435193
https://pubmed.ncbi.nlm.nih.gov/9435193
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46(3)
Objective and Design: The therapeutic effects of an anti-resorptive agent, clodronate, were compared with the effects of an anti-inflammatory agent, indomethacin, in rat adjuvant arthritis after therapy and after a follow-up time of two weeks. ¶Subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ca9fdeff5d9a5e1df4d8e532dcad01
https://pubmed.ncbi.nlm.nih.gov/9098719
https://pubmed.ncbi.nlm.nih.gov/9098719
Distribution of clodronate in the bone of adult rats and its effects on trabecular and cortical bone
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
Distribution of clodronate in cancellous and cortical bone of the femur and in cancellous bone of lumbar vertebrae in adult rats was examined by means of quantitative autoradiography. In addition, the effects of clodronate on cancellous and cortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::441975f793483fe0aea16031b051e6ef
https://pubmed.ncbi.nlm.nih.gov/9023323
https://pubmed.ncbi.nlm.nih.gov/9023323
Autor:
T, Osterman, T, Virtamo, L, Laurén, K, Kippo, I, Pasanen, R, Hannuniemi, K, Väänänen, R, Sellman
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
The effects of slow-release calcium clodronate on rat adjuvant arthritis were investigated using two different dosing schedules. In prophylactic treatment, calcium clodronate was given on the same day as the adjuvant injection, and in therapeutic tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b45aa82124c40c4ed88429c2b0faad6
https://pubmed.ncbi.nlm.nih.gov/9023317
https://pubmed.ncbi.nlm.nih.gov/9023317
Publikováno v:
Molecular pharmacology. 50(5)
Bisphosphonates (BPs), such as clodronate and pamidronate, are inhibitors of bone resorption and are used on a widespread basis in the treatment of hyper-resorptive bone diseases. At the cellular level, BPs inhibit osteoclasts, but the precise molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e18f636ae76c643d792be50cef34d74
https://pubmed.ncbi.nlm.nih.gov/8913344
https://pubmed.ncbi.nlm.nih.gov/8913344
Publikováno v:
Rheumatology international. 14(4)
The rat adjuvant arthritis model was used to study the effect of disodium clodronate on inflammation and destruction of tarsal bones and joints. Male Lewis rats were given an intradermal injection of mycobacteria. Fourteen days after immunization, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f268b849beb514a3ef24830d1a59f266
https://pubmed.ncbi.nlm.nih.gov/7871332
https://pubmed.ncbi.nlm.nih.gov/7871332