Zobrazeno 1 - 10 of 35 pro vyhledávání: '"R. H. Griffey"'
2
Temperature-dependent Raman and infrared spectra of nucleosides. II?Cytidine
Autor: Scott Lee, A. Anderson, J.F. Li, W. Smith, R. H. Griffey, V. Mohan
Publikováno v: Journal of Raman Spectroscopy. 32:795-802
Raman and infrared spectra were recorded for crystalline deoxycytidine samples at 300, 200, 100 and 10 K. Data were taken over the spectral range 20–4000 cm−1. The wavenumbers of most vibrational modes were found to increase as the temperature wa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::703e72b20bc1ad883f173b7fae7ec5df
https://doi.org/10.1002/jrs.749
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3
Base opening in RNA and DNA duplexes: Implication for RNA stability
Autor: Yu Zong Chen, R. H. Griffey, V. Mohan
Publikováno v: Physical Review E. 61:5640-5645
The energetics of a low-energy single base opening in several RNA duplex crystal structures has been calculated and compared to DNA duplexes. Base opening in RNA appears to have an overall preference towards the major groove, similar to results previ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171c7633104f6b18259fe5c571c39f5e
https://doi.org/10.1103/physreve.61.5640
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6
The Opening of a Single Base Without Perturbations of Neighboring Nucleotides: A Study on Crystal B-DNA duplex d(CGCGAATTCGCG)2
Autor: Yu Zong Chen, R. H. Griffey, V. Mohan
Publikováno v: Journal of Biomolecular Structure and Dynamics. 15:765-777
In this work we explore the possibility of the opening of a single base without perturbation of its neighboring nucleotides. Low energy base opening into the grooves can be accomplished by rotation of the relevant backbone and glycosidic bond torsion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b648fa60a87693e228730706fbc864
https://doi.org/10.1080/07391102.1998.10508991
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8
Mass spectrometry as a drug discovery platform against RNA targets
Autor: S A, Hofstadler, R H, Griffey
Publikováno v: Current opinion in drug discoverydevelopment. 3(4)
Mass spectrometry continues to play an increasingly important role in the drug discovery arena. In many drug discovery and biotechnology environments, mass spectrometry constitutes an integral component of the entire drug discovery and development pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e355e23f122cf4b570ff5e8abd9e3d84
https://pubmed.ncbi.nlm.nih.gov/19649873
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9
Eigenvector-Based Spectral Enhancement of Nuclear Magnetic Resonance Profiles of Small Volumes from Human Brain Tissue
Autor: Ramiro Jordan, G. P. Abousleman, R. H. Griffey
Publikováno v: Applied Spectroscopy. 45:202-208
Nuclear Magnetic Resonance (NMR) spectroscopy is a low-energy technique which suffers from poor inherent signal-to-noise ratio (SNR). In a clinical setting, it is often desirable to study small regions of tissue in patients to aid in the detection an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d630f6442eb27f0a4b06bd2bd315dbee
https://doi.org/10.1366/0003702914337524
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10
Effect of hypoxia on cerebral metabolites measured by proton nuclear magnetic resonance spectroscopy in rats
Autor: R. H. Griffey, E A Crisostomo, Gary A. Rosenberg, C. Gasparovic, J White
Publikováno v: Stroke. 22:73-79
Proton nuclear magnetic resonance spectroscopy is a unique method to monitor noninvasively the concentrations of cerebral metabolites. N-Acetyl-L-aspartate, the concentration of which is assumed to be stable during hypoxia, has been used to form rati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2336fc31601aaa173d1361dba72bacd0
https://doi.org/10.1161/01.str.22.1.73
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