Zobrazeno 1 - 10
of 31
pro vyhledávání: '"R. Guastella"'
Autor:
N. Mancin, R. Guastella, J. T. Carlton, A. Caruso, M. Cobianchi, J. Evans, L. Capotondi, L. Langone, A. Marchini
Publikováno v:
Biological Invasions. 25:1265-1283
Autor:
Prakash Chinnaiyan, Ichiro Nakano, Katie L. Buelow, Stewart F. Graham, Praveen Kumar, Anthony R. Guastella, Pravin Kesarwani, Shiva Kant
Glioblastoma is the most common primary malignant brain tumor in adults. Despite aggressive treatment, outcomes remain poor with few long-term survivors. Therefore, considerable effort is being made to identify novel therapies for this malignancy. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684c710ca240f12ed5a5a431bc53726d
https://doi.org/10.1158/1535-7163.c.6542883
https://doi.org/10.1158/1535-7163.c.6542883
Autor:
Prakash Chinnaiyan, Ichiro Nakano, Katie L. Buelow, Stewart F. Graham, Praveen Kumar, Anthony R. Guastella, Pravin Kesarwani, Shiva Kant
Supplementary Figures_Unmarked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef2fb4d806bec4e367c45ed17eb1072
https://doi.org/10.1158/1535-7163.22521042
https://doi.org/10.1158/1535-7163.22521042
Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma
Autor:
Anthony R. Guastella BS, Sharon K. Michelhaugh PhD, Neil V. Klinger MS, William J. Kupsky MD, Lisa A. Polin PhD, Otto Muzik PhD, Csaba Juhász MD, PhD, Sandeep Mittal MD, FRCSC, FACS
Publikováno v:
Molecular Imaging, Vol 15 (2016)
Increasing evidence demonstrates the immunosuppressive kynurenine pathway’s (KP) role in the pathophysiology of human gliomas. To study the KP in vivo, we used the noninvasive molecular imaging tracer α-[ 11 C]-methyl- l -tryptophan (AMT). The AMT
Externí odkaz:
https://doaj.org/article/bf123b80ad2a43db945e275c5eed7edf
Autor:
Sam Kiousis, Hassan Fadel, Csaba Juhász, Neil V. Klinger, Sharon K. Michelhaugh, Rouba Ali-Fehmi, Sandeep Mittal, William J. Kupsky, Anthony R. Guastella
Publikováno v:
Journal of Neuro-Oncology. 139:239-249
INTRODUCTION: There is mounting evidence supporting the role of tryptophan metabolism via the kynurenine pathway (KP) in the pathogenesis of primary brain tumors. Under normal physiological conditions, the KP is the major catabolic pathway for the es
Akademický článek
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Autor:
Katie Buelow, Prakash Chinnaiyan, Pravin Kesarwani, Ichiro Nakano, Shiva Kant, Praveen Kumar, Stewart F. Graham, Anthony R. Guastella
Publikováno v:
Mol Cancer Ther
Glioblastoma is the most common primary malignant brain tumor in adults. Despite aggressive treatment, outcomes remain poor with few long-term survivors. Therefore, considerable effort is being made to identify novel therapies for this malignancy. Ta
Autor:
Pravin Kesarwani, Ichiro Nakano, Antony Prabhu, Anthony R. Guastella, Prakash Chinnaiyan, Shiva Kant
Publikováno v:
Neuro Oncol
Despite advances in molecularly characterizing glioblastoma, metabolic alterations driving its aggressive phenotype are only beginning to be recognized. Integrative cross-platform analyses coupling global metabolomic and gene expression profiling ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b226cb6027607bfa94d1136d29c3c404
https://europepmc.org/articles/PMC6847795/
https://europepmc.org/articles/PMC6847795/
Akademický článek
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Autor:
Csaba Juhász, Neil V. Klinger, Hancheng Cai, Otto Muzik, Yangchun Xin, Sharon K. Michelhaugh, Sandeep Mittal, Thomas J. Mangner, Shaohui Zhang, Anthony R. Guastella, Lisa Polin
Publikováno v:
Journal of Nuclear Medicine. 58:208-213
Abnormal tryptophan metabolism via the kynurenine pathway (KP) is involved in the pathophysiology of a variety of human diseases including cancers. α-[11C]-methyl-L-tryptophan (11C-AMT) positron emission tomography (PET) imaging demonstrated increas