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Autor: Theresa M. Williams, R. Grayshan, J.H. Fried, A. Semenovski, I.T. Harrison

Publikováno v: Tetrahedron Letters. 13:5151-5154

The wide range of biological activity of the PGs (prostaglandins) has caused chemists to seek more specific agents and antagonists among PG analogs of the natural compounds. This is an explanation of the synthesis of DL 911-bis-homo-prostaglandin F1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b11cfb3138160de8508d1b74da1f020
https://doi.org/10.1016/s0040-4039(01)85193-5

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Conformational free energy differences in steroids. Part II. Equilibration of 3α-methyl-5α- and -5β-cholestan-6-ones, and of 3α-chloro-5α- and -5β-cholestan-6-ones

Autor: D. Neville Jones, R. Grayshan, D. E. Kime

Publikováno v: J. Chem. Soc. C. :48-54

The conformational preference of the methyl group determined by equilibration of 3α-methyl-5α-cholestan-6-one with its 5β-isomer agreed well with values obtained in other systems. For 3α-chlorine the method is invalidated by electrostatic interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcbf67d49acf5b6949f6fa346f9c7e69
https://doi.org/10.1039/j39690000048

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Conformational free energy differences in steroids. Part V. Equilibration of 5α- and 5β-androstan-6-one derivatives structurally modified in ringD

Autor: D. Neville Jones, R. Grayshan

Publikováno v: J. Chem. Soc. C. :2421-2426

The presence of 17β-groups (methoxy-, acetoxy-, ethyl, or 1,5-dimethylhexyl) or of unsaturation in ring D had little effect upon the position of equilibrium between substituted 5α- and 5β-androstan-6-ones.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c42376005343bbf0c55de163ed48424
https://doi.org/10.1039/j39700002421

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Conformational free energy differences in steroids. Part III. Equilibration of 3α-hydroxy-, 3α-methoxy-, and 3α-acetoxy-5β-cholestan-6-ones with their 5α-isomers

Autor: R. Grayshan, A. Hinchcliffe, D. E. Kime, D. Neville Jones

Publikováno v: J. Chem. Soc. C. :1208-1215

The equilibria mentioned in the title are influenced by electrostatic interactions between the 3α-substituents and the C-6 keto-group, calculated values for which are in accord with the observed effects. Restricted rotation in the axial hydroxy- and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f071ccec98fe6fe4be10d3b058ab35e
https://doi.org/10.1039/j39690001208

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Radiopharmaceuticals for myocardial infarct imaging: a clinical comparison of 99Tcm-pyrophosphate and 99Tcm-dimethylaminomethylene diphosphonate

Autor: A M Millar, R. Grayshan, A L Muir, Derek Bell

Publikováno v: The British journal of radiology. 61(727)

99Tcm-pyrophosphate (PYP) has been shown to concentrate in acutely damaged myocardium (Bonte et al, 1974). This has resulted in myocardial infarct imaging with 99Tcm-PYP becoming an established technique in nuclear medicine (Bruno et al, 1976; Parkey

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a06228dfd746a50d267c45115ada7d
https://pubmed.ncbi.nlm.nih.gov/2702392

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