Výsledky vyhledávání - "R. Graham Hope"

Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets

Autor: R. Graham Hope, John McLauchlan, Roland Montserret, Jean-Pierre Lavergne, Francoise Penin, Steeve Boulant, Maxime Ratinier, Paul Targett-Adams

Publikováno v: Journal of Biological Chemistry. 281:22236-22247

Hepatitis C virus core protein is targeted to lipid droplets, which serve as intracellular storage organelles, by its C-terminal domain, termed D2. From circular dichroism and nuclear magnetic resonance analyses, we demonstrate that the major structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2fd2b19fc3dd263785b716f290b4c2
https://doi.org/10.1074/jbc.m601031200

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Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1

Autor: John McLauchlan, Marion McElwee, R. Graham Hope

Publikováno v: Journal of General Virology. 87:623-627

Maturation of hepatitis C virus (HCV) core protein requires cleavage by signal peptidase (SP) and signal peptide peptidase (SPP) at a signal peptide between core and the E1 glycoprotein. For HCV strain Glasgow, amino acids Ala180, Ser183 and Cys184 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f910cb0848641bb2ca5eb5516fc2d316
https://doi.org/10.1099/vir.0.81371-0

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Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein

Autor: R. Graham Hope, John McLauchlan

Publikováno v: Journal of General Virology. 81:1913-1925

From analysis of the primary sequence of the hepatitis C virus (HCV) core protein, we have identified three separable regions based on hydrophobicity and clustering of basic amino acids within the protein. Comparison with capsid proteins of related p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be2e12115c3d546a5cb3e588fbaf336
https://doi.org/10.1099/0022-1317-81-8-1913

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Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein

Autor: Sarah Gledhill, John McLauchlan, R. Graham Hope, Paul Targett-Adams, Johannes F. Coy, Doreen Chambers, Andreas Girod

Publikováno v: The Journal of biological chemistry. 278(18)

Neutral lipid is stored in spherical organelles called lipid droplets that are bounded by a coat of proteins. The protein that is most frequently found at the surface of lipid droplets is adipocyte differentiation-related protein (ADRP). In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1388d3212316e7a5a696035f817c4aa8
https://pubmed.ncbi.nlm.nih.gov/12591929

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The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins

Autor: R. Graham Hope, Denis J. Murphy, John McLauchlan

Publikováno v: The Journal of biological chemistry. 277(6)

In mammalian tissue culture cells, the core protein of hepatitis C virus (HCV) is located at the surface of lipid droplets, which are cytoplasmic structures that store lipid. The critical amino acid sequences necessary for this localization are in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbf1cecf88f628ff336646cc87ad9b7
https://pubmed.ncbi.nlm.nih.gov/11706032

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