Zobrazeno 1 - 10
of 29
pro vyhledávání: '"R. Grace Walton"'
Autor:
Kate Kosmac, Marta Gonzalez‐Freire, Mary M. McDermott, Sarah H. White, R. Grace Walton, Robert L. Sufit, Lu Tian, Lingyu Li, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Tamar S. Polonsky, Christiaan Leeuwenburgh, Luigi Ferrucci, Charlotte A. Peterson
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 10 (2020)
Background Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility loss. Preliminary evidence suggests PAD damages skeletal muscle, resulting in muscle impairment
Externí odkaz:
https://doaj.org/article/29819e9cb8a54c9cb5df3b007eb2c817
Autor:
Ahmad Al-Attar, Steven R. Presnell, Jody L. Clasey, Douglas E. Long, R. Grace Walton, Morgan Sexton, Marlene E. Starr, Philip A. Kern, Charlotte A. Peterson, Charles T. Lutz
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Natural killer (NK) lymphocyte-mediated cytotoxicity and cytokine secretion control infections and cancers, but these crucial activities decline with age. NK cell development, homeostasis, and function require IL-15 and its chaperone, IL-15 receptor
Externí odkaz:
https://doaj.org/article/4b8b62374a2d4edcb186181fd0beafe0
Autor:
R. Grace Walton, Diane Begemann, Cynthia Dunn, Valeria Steffey, Abigail Ross, Razoanul Haque, Fallon K. Noto
Publikováno v:
Molecular Cancer Research. 21:A040-A040
RAS family proteins are important drug targets in multiple cancers due to their central role in hypertrophic and pro-mitotic signaling. KRAS is a small GTPase that is activated in response to growth factors including HGF, TGFα, and EGF. KRAS then ac
Autor:
Diane Begemann, Aida Javidan, Cynthia Dunn, Nicolas Johnston, R. Grace Walton, Valeriya Steffey, Ian Corbin, Niveen Fulcher, Cleusa De Oliveira, Hu Xu, Mila Uzelac, Andrew Deweyert, John A. Ronald, Susanne Schmid, Matthew O. Hebb, Fallon K. Noto
Publikováno v:
Cancer Research. 83:42-42
Human cancer xenografts are a vital tool for understanding tumor biology, growth kinetics, and therapeutic efficacy using animal models. Historically, immunodeficient mice have been the standard rodent species for cancer xenograft modeling. However,
Autor:
Zhengyan Huang, Marcas M. Bamman, R. Grace Walton, Bailey D. Peck, Philip A. Kern, Charlotte A. Peterson, Cory M. Dungan
Publikováno v:
FASEB J
Over the past 20 years, various identifiers of cellular senescence have been used to quantify the abundance of these cells in different tissues. These include classic markers such as p16, senescence-associated β-gal, and γH2AX, in addition to more
Autor:
Bailey D. Peck, Kevin A. Murach, R. Grace Walton, Alexander J. Simmons, Douglas E. Long, Kate Kosmac, Cory M. Dungan, Philip A. Kern, Marcas M. Bamman, Charlotte A. Peterson
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(2)
The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue development, structural support, and force transmission. For successful adaptation to mechanical loading, remodeling processes must occur. In a large cohort of older a
Autor:
Ivan J. Vechetti, Björn Alkner, Charlotte A. Peterson, Taylor Valentino, Douglas W. Van Pelt, John J. McCarthy, Ferdinand von Walden, Cory M. Dungan, Bailey D. Peck, R. Grace Walton, Yuan Wen, Alexander P. Alimov
Publikováno v:
FASEB J
How regular physical activity is able to improve health remains poorly understood. The release of factors from skeletal muscle following exercise has been proposed as a possible mechanism mediating such systemic benefits. We describe a mechanism wher
Autor:
Kate Kosmac, R. Grace Walton, Beibei Zhu, Brian S. Finlin, Philip A. Kern, Jyothi Mula, Jason S. Groshong, Bailey D. Peck, Charlotte A. Peterson, Christopher S. Fry
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Skeletal muscle macrophages participate in repair and regeneration following injury. However, their role in physiological adaptations to exercise is unexplored. We determined whether endurance exercise training (EET) alters macrophage content and cha
Autor:
Marcas M. Bamman, Douglas E. Long, Bailey D. Peck, Margaret B. Bell, Jeremy McAdam, Samuel T. Windham, Charlotte A. Peterson, Kaleen M. Lavin, S. Craig Tuggle, Phillip A Kern, R. Grace Walton
Publikováno v:
Physiol Genomics
The skeletal muscle hypertrophic response to resistance exercise training (RT) is highly variable across individuals. The molecular underpinnings of this heterogeneity are unclear. This study investigated transcriptional networks linked to RT-induced
Autor:
Samuel T. Windham, Philip A. Kern, Marcas M. Bamman, Bailey D. Peck, Charlotte A. Peterson, Ameya S Kulkarni, Jessica C. Mar, Nir Barzilai, R. Grace Walton
Publikováno v:
Aging (Albany NY)
Evidence from clinical trials and observational studies suggests that both progressive resistance exercise training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effects of 14 we