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Akademický článek

Cigarette smoke restricts the ability of mesenchymal cells to support lung epithelial organoid formation

Autor: P. P. S. J. Khedoe, W. A. A. M. van Schadewijk, M. Schwiening, J. P. Ng-Blichfeldt, S. J. Marciniak, J. Stolk, R. Gosens, P. S. Hiemstra

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Adequate lung epithelial repair relies on supportive interactions within the epithelial niche, including interactions with WNT-responsive fibroblasts. In fibroblasts from patients with chronic obstructive pulmonary disease (COPD) or upon in vitro cig

Externí odkaz: https://doaj.org/article/6e8b07afb5534fd6992ec59bb2ab9c47

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Akademický článek

Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies

Autor: P. A. Goldsteen, A. M. Sabogal Guaqueta, P. P. M. F. A. Mulder, I. S. T. Bos, M. Eggens, L. Van der Koog, J. T. Soeiro, A. J. Halayko, K. Mathwig, L. E. M. Kistemaker, E. M. J. Verpoorte, A. M. Dolga, R. Gosens

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Airway cholinergic nerves play a key role in airway physiology and disease. In asthma and other diseases of the respiratory tract, airway cholinergic neurons undergo plasticity and contribute to airway hyperresponsiveness and mucus secretion. We curr

Externí odkaz: https://doaj.org/article/5ff0e13c81744b1895f503c1c0444fce

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Akademický článek

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

Autor: J. Song, I. H. Heijink, L. E. M. Kistemaker, M. Reinders-Luinge, W. Kooistra, J. A. Noordhoek, R. Gosens, C. A. Brandsma, W. Timens, P. S. Hiemstra, M. G. Rots, M. N. Hylkema

Publikováno v: Clinical Epigenetics, Vol 9, Iss 1, Pp 1-10 (2017)

Abstract Background Goblet cell metaplasia, a common feature of chronic obstructive pulmonary disease (COPD), is associated with mucus hypersecretion which contributes to the morbidity and mortality among patients. Transcription factors SAM-pointed d

Externí odkaz: https://doaj.org/article/3865a4c59b434476b3320516130fb0ae

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Age-associated differences in the human lung extracellular matrix

Autor: M.L. Koloko Ngassie, M. De Vries, T. Borghuis, W. Timens, Don D. Sin, D. Nickle, P. Joubert, P. Horvatovich, G. Marko-Varga, J.J. Teske, J.M. Vonk, R. Gosens, Y.S. Prakash, J.K. Burgess, C.A. Brandsma

Publikováno v: American Journal of Physiology - Lung Cellular and Molecular Physiology. 324(6):799-814

IntroductionExtracellular matrix (ECM) remodelling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung ECM is currently limited. In this study we aimed to identify and localize age-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4486ec0619ed5676ca69dd4c11d78c9
https://research.rug.nl/en/publications/39666b6b-f667-48f7-adba-afffa8bf1432

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