Zobrazeno 1 - 10
of 52
pro vyhledávání: '"R. Gitendra Wickremasinghe"'
Autor:
R. Gitendra Wickremasinghe, Lena Rai, Adele K. Fielding, Shaji Kumar, Jennifer M. Thomson, Aditi Dey, Bella Patel, Yu Zhang, Andrew J. Steele, Yogeshkumar Malam, Anna Castleton, Ehsan Ghorani
Publikováno v:
Molecular Therapy. 19:1034-1040
Clinical trials using vaccine measles virus (MV) as anticancer therapy are already underway. We compared the oncolytic potential of MV in two B-cell malignancies; adult acute lymphoblastic leukemia (ALL, an aggressive leukemia) and chronic lymphocyti
Publikováno v:
British Journal of Haematology. 153:545-556
Chronic lymphocytic leukaemia (CLL) is the commonest haematological malignancy in the western world and is incurable by cytotoxic therapy. Considerable research effort has identified the signal transduction pathways in CLL cells that contribute to an
Autor:
Veronique Duke, Birunthini C. Yogashangary, Elisabeth P. Nacheva, Stephen M. Hart, Archibald G. Prentice, Julie Howard-Reeves, R. Gitendra Wickremasinghe, Kate Cwynarski, Andrew J. Steele, Panagiotis D. Kottaridis, A. Victor Hoffbrand, Lyubomir T. Vassilev
Publikováno v:
Blood. 112:3827-3834
The p53 protein plays a key role in securing the apoptotic response of chronic lymphocytic leukemia (CLL) cells to genotoxic agents. Transcriptional induction of proapoptotic proteins including Puma are thought to mediate p53-dependent apoptosis. In
Autor:
Elena Addison, R. Gitendra Wickremasinghe, Mark W. Lowdell, Ismail Bakhsh, Jeff K. Davies, Sumaira Haq, Samia Al-Sarraj, Chloe Marden, Reza Malayeri, Janet North
Publikováno v:
Immunology. 116:354-361
It has been previously shown that the subset of human natural killer (NK) cells which express CD8 in a homodimeric alpha/alpha form are more cytotoxic than their CD8(-) counterparts but the mechanisms behind this differential cytolytic activity remai
Autor:
Wayne A. Mitchell, R. Gitendra Wickremasinghe, Dylan T. Jones, H. Grant Prentice, Letizia Foroni, Atul Mehta, Kanagasabai Ganeshaguru, RJ Baker
Publikováno v:
British Journal of Haematology. 121:713-720
We have studied the actions of tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) on cells isolated from patients with acute myeloid leukaemia (AML). Apoptosis induction was initially assessed by quantitative morphological analysis. Onl
Autor:
Victoria J. Spanswick, Caroline Lindsay, Robin Thorpe, Dylan T. Jones, Meenu Wadhwa, R. Gitendra Wickremasinghe, A. Victor Hoffbrand, Atul Mehta, H. Grant Prentice, John A. Hartley, Kanagasabai Ganeshaguru
Publikováno v:
British Journal of Haematology. 114:608-615
We have studied the actions of autologous plasma on both basal and DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia (B-CLL) cells. Apoptosis was quantified using morphological criteria and Western blot analysis for the apoptosis-specif
Publikováno v:
Blood. 93:3587-3600
G ENETIC CHANGES involving oncogenes and tumor suppressor genes contribute to the deregulated expansion of malignant cells. While some of these changes result in increased proliferation, others contribute to an increase in cell numbers by inhibiting
Autor:
Karen E. Noble, R. Gitendra Wickremasinghe, Chris DeCornet, Panayiotis Panayiotidis, Kwee L. Yong
Publikováno v:
The Journal of Immunology. 162:1376-1383
We have investigated the molecular mechanisms underlying the ability of peripheral blood monocytes to block apoptosis induction in endothelial cells. Monocytes stimulated the expression of the bcl-2 homologue A1 in serum-starved endothelial cells aft
Autor:
R. Gitendra Wickremasinghe, Margarita Bofill, Lynette D. Fairbanks, Nicola Borthwick, Jackie Lewin
Publikováno v:
The Journal of Infectious Diseases. 179:352-360
Mitogenic stimulation of lymphocytes from persons infected with human immunodeficiency virus (HIV) resulted in massive cell death. In addition to early apoptosis, a second wave of cell death occurred 48-72 h after stimulation. At that time, the cells
Autor:
Fiona A Riordan, Christopher A Bravery, Kamuran Mengubas, Nandita Ray, Nicola J Borthwick, Arne N Akbar, Steven M Hart, A Victor Hoffbrand, Atul B Mehta, R Gitendra Wickremasinghe
Publikováno v:
Oncogene. 16:1533-1542
Philadelphia chromosome (Ph)-positive leukaemia cells express the chimeric bcr/abl oncoprotein, whose deregulated protein tyrosine kinase (PTK) activity antagonizes the induction of apoptosis by DNA damaging agents, Treatment of Ph-positive K562, TOM