Zobrazeno 1 - 10
of 1 690
pro vyhledávání: '"R. Gillespie"'
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 5, Pp 1039-1042 (2024)
In Latin America, rabies virus has persisted in a cycle between Desmodus rotundus vampire bats and cattle, potentially enhanced by deforestation. We modeled bovine rabies virus outbreaks in Costa Rica relative to land-use indicators and found spatial
Externí odkaz:
https://doaj.org/article/74d2414ae1d14a56a5407a20cdbe94ff
Autor:
Ellen R. Gillespie, Laura F. Grice, Isabel G. Courtney, Hong Wa Lao, Woncheol Jung, Sonny Ramkomuth, Jacky Xie, David A. Brown, James Walsham, Kristen J. Radford, Quan H. Nguyen, Marc J. Ruitenberg
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Next-generation humanised mouse models and single-cell RNA sequencing (scRNAseq) approaches enable in-depth studies into human immune cell biology. Here we used NSG-SGM3 mice engrafted with human umbilical cord haematopoietic stem cells to i
Externí odkaz:
https://doaj.org/article/40a7cde76523424a9dc3bc7e32ce0e7a
Autor:
Emily K. Strahan, Jacob Witherbee, Richard Bergl, Elizabeth V. Lonsdorf, Dismas Mwacha, Deus Mjungu, Mimi Arandjelovic, Romanus Ikfuingei, Karen Terio, Dominic A. Travis, Thomas R. Gillespie
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 3, Pp 577-580 (2024)
Despite zoonotic potential, data are lacking on enteric infection diversity in wild apes. We employed a novel molecular diagnostic platform to detect enteric infections in wild chimpanzees and gorillas. Prevalent Cryptosporidium parvum, adenovirus, a
Externí odkaz:
https://doaj.org/article/398da75919954093bd167b5df305e4ab
Autor:
Kosalaram Goteti, Ramon Garcia, William R. Gillespie, Jonathan French, Lena Klopp‐Schulze, Ying Li, Cristina Vazquez Mateo, Sanjeev Roy, Oliver Guenther, Lisa Benincosa, Karthik Venkatakrishnan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 2, Pp 281-295 (2024)
Abstract Several investigational agents are under evaluation in systemic lupus erythematosus (SLE) clinical trials but quantitative frameworks to enable comparison of their efficacy to reference benchmark treatments are lacking. To benchmark SLE trea
Externí odkaz:
https://doaj.org/article/7bef3d63ff144d048d023a316148b601
Autor:
Curtis K. Johnston, Timothy Waterhouse, Matthew Wiens, John Mondick, Jonathan French, William R. Gillespie
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 2, Pp 192-207 (2024)
Abstract Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (
Externí odkaz:
https://doaj.org/article/ae54291dd9fb46a69fd56bcbdb22f125
Autor:
Brooke M. Talbot, Julie A. Clennon, Miarintsoa Fara Nantenaina Rakotoarison, Lydia Rautman, Sarah Durry, Leo J. Ragazzo, Patricia C. Wright, Thomas R. Gillespie, Timothy D. Read
Publikováno v:
PeerJ, Vol 12, p e17805 (2024)
Background Tracking the spread of antibiotic resistant bacteria is critical to reduce global morbidity and mortality associated with human and animal infections. There is a need to understand the role that wild animals in maintenance and transfer of
Externí odkaz:
https://doaj.org/article/2ee8d7a49ab84519aa90e8860e69a0e6
Autor:
Kelsey L. Neuenswander, Grace S. R. Gillespie, David J. Lick, Gregory A. Bryant, Kerri L. Johnson
Publikováno v:
Royal Society Open Science, Vol 11, Iss 3 (2024)
People form social evaluations of others following brief exposure to their voices, and these impressions are calibrated based on recent perceptual experience. Participants adapted to voices with fundamental frequency (f o; the acoustic correlate of p
Externí odkaz:
https://doaj.org/article/841f68c6df1046ac906ebc9d9dde739a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 4, Pp 462-473 (2023)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B‐cell hyperactivity and breach of tolerance. Autoreactive memory B cells, which have a decreased activation threshold and the ability to survive in absence of an
Externí odkaz:
https://doaj.org/article/757f986ec1034a9a83e9e39cfda175c6
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 3, Pp 300-310 (2023)
Abstract Physiologically‐based pharmacokinetic (PBPK) models are mechanistic models that are built based on an investigator's prior knowledge of the in vivo system of interest. Bayesian inference incorporates an investigator's prior knowledge of pa
Externí odkaz:
https://doaj.org/article/41fe5f01aca04a3a9cc050cfe24109bb
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1151-1169 (2022)
Abstract Stan is an open‐source probabilistic programing language, primarily designed to do Bayesian data analysis. Its main inference algorithm is an adaptive Hamiltonian Monte Carlo sampler, supported by state‐of‐the‐art gradient computatio
Externí odkaz:
https://doaj.org/article/3b351ae7ef8447eabf471490b1ee26c9