Výsledky vyhledávání

Altered‐specificity mutants of the HIV Rev arginine‐rich motif‐RRE IIB interaction

Autor: Colin A. Smith, Natsuki Watanabe, Ingrid R. Ghattas, Ryo Amano, Nicole G. Raad, Taiichi Sakamoto

Publikováno v: Journal of Molecular Recognition. 33

Arginine-rich motifs (ARMs) bind RNA structures with high affinity and specificity, and the human immunodeficiency virus (HIV) exploits ARM-RNA interactions to regulate its lifecycle. The expression of HIV structural genes relies on recognition betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa3bcbef1877f456f499d860f21502a
https://doi.org/10.1002/jmr.2833

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Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Autor: Colin A. Smith, Maroun Bou Sleiman, Ingrid R. Ghattas, Elite Possik

Publikováno v: Journal of Molecular Recognition. 26:286-296

The binding of the arginine-rich motif (ARM) of HIV Rev protein to its high-affinity site in stem IIB in the Rev response element (RRE) initiates assembly of a ribonucleoprotein complex that mediates the export of essential, incompletely spliced vira

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0311df7f008b26194728af15c1faf65e
https://doi.org/10.1002/jmr.2272

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Bacteriophage P22 Antitermination boxB Sequence Requirements Are Complex and Overlap with Those of λ

Autor: Colin A. Smith, Alexis I. Cocozaki, Ingrid R. Ghattas

Publikováno v: Journal of Bacteriology. 190:4263-4271

Transcription antitermination in phages λ and P22 uses N proteins that bind to similar boxB RNA hairpins in regulated transcripts. In contrast to the λ N-boxB interaction, the P22 N-boxB interaction has not been extensively studied. A nuclear magne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56faab8b937fa7f005c0222a7d361ad
https://doi.org/10.1128/jb.00059-08

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HK022 Nun Requires Arginine-Rich Motif Residues Distinct from λ N

Autor: Ingrid R. Ghattas, Colin A. Smith, Caroline S. Tawk

Publikováno v: Journal of bacteriology. 197(22)

Bacteriophage λ N protein binds boxB RNA hairpins in the nut (N utilization) sites of immediate early λ transcripts and interacts with host factors to suppress transcriptional termination at downstream terminators. In opposition to λ N, the Nun pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8329cea65fdba2e2d518ec20694ed0e9
https://pubmed.ncbi.nlm.nih.gov/26350130

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Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Autor: Elite J, Possik, Maroun S, Bou Sleiman, Ingrid R, Ghattas, Colin A, Smith

Publikováno v: Journal of molecular recognition : JMR. 26(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03ea9fe8945f03a91840dc0501949dca
https://pubmed.ncbi.nlm.nih.gov/23595810

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The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

Autor: Joshua R. Sanes, I. R. Ghattas, John Majors

Publikováno v: Molecular and Cellular Biology. 11:5848-5859

Rous sarcoma virus-based retroviral vectors were constructed to compare three different approaches for coexpressing two genes in individual infected cells. All vectors expressed the upstream gene (lacZ) from the Rous sarcoma virus long terminal repea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ba6261852d2f3184caf26b46bc9723
https://doi.org/10.1128/mcb.11.12.5848-5859.1991

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The RNA-Binding Domain of Bacteriophage P22 N Protein Is Highly Mutable, and a Single Mutation Relaxes Specificity toward λ▿

Autor: Colin A. Smith, Ingrid R. Ghattas, Alexis I. Cocozaki

Antitermination in bacteriophage P22, a lambdoid phage, uses the arginine-rich domain of the N protein to recognize boxB RNAs in the nut site of two regulated transcripts. Using an antitermination reporter system, we screened libraries in which each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea32bb18aa1e554a25b991d712401f6
https://europepmc.org/articles/PMC2583623/

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Preemption Threshold Scheduling: Stack Optimality, Enhancements and Analysis

Autor: R. Ghattas, A.C. Dean

Publikováno v: IEEE Real-Time and Embedded Technology and Applications Symposium

Using preemption threshold scheduling (PTS) in a multi-threaded real-time embedded system reduces system preemptions and hence reduces run-time overhead while still ensuring real-time constraints are met. However, PTS offers other valuable benefits.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f190792f0c1ff7d83e59387e3cf21f0
https://doi.org/10.1109/rtas.2007.27

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Optimal Unified Data Allocation and Task Scheduling for Real-Time Multi-Tasking Systems

Autor: Gregory N. Parsons, Alexander G. Dean, R. Ghattas

Publikováno v: IEEE Real-Time and Embedded Technology and Applications Symposium

Many real-time (RT) embedded systems can benefit from a memory hierarchy to bridge the processor/memory speed gap. These RT embedded systems usually utilize a cacheless architecture to avoid the time variability which complicates the timing analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::901c9b906cb839c331c4192313b6ef3d
https://doi.org/10.1109/rtas.2007.23

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