Zobrazeno 1 - 10
of 384
pro vyhledávání: '"R. Gershon"'
Autor:
Daniel Shiloh Malawsky, Taylor Dismuke, Hedi Liu, Ethan Castellino, Jay Brenman, Biplab Dasgupta, Andrey Tikunov, Timothy R. Gershon
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108443- (2023)
Summary: We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem cells and slows progression. In medulloblastoma, the most common malignant pediatric brain tumor, drug-resistant stem cells co-exist with transit-amplifyin
Externí odkaz:
https://doaj.org/article/ce27806c9aa3458681f0983682896568
Autor:
Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Medulloblastoma (MB) is the most common pediatric brain malignancy and is divided into four molecularly distinct subgroups: WNT, Sonic Hedgehog (SHHp53mut and SHHp53wt), Group 3, and Group 4. Previous reports suggest that SHH MB features a u
Externí odkaz:
https://doaj.org/article/0cd8c8f588934e6087c82e48042e31b0
Autor:
Abigail H. Cleveland, Daniel Malawsky, Mehal Churiwal, Claudia Rodriguez, Frances Reed, Matthew Schniederjan, Jose E. Velazquez Vega, Ian Davis, Timothy R. Gershon
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract We show that Polycomb Repressive Complex-2 (PRC2) components EED and EZH2 maintain neural identity in cerebellar granule neuron progenitors (CGNPs) and SHH-driven medulloblastoma, a cancer of CGNPs. Proliferating CGNPs and medulloblastoma ce
Externí odkaz:
https://doaj.org/article/da95e9bb36f24f898a4974b26fb6a823
Autor:
Abigail H. Cleveland, Alejandra Romero-Morales, Laurent Alfonso Azcona, Melisa Herrero, Viktoriya D. Nikolova, Sheryl Moy, Orna Elroy-Stein, Vivian Gama, Timothy R. Gershon
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Neurologic disorders often disproportionately affect specific brain regions, and different apoptotic mechanisms may contribute to white matter pathology in leukodystrophies or gray matter pathology in poliodystrophies. We previously showed t
Externí odkaz:
https://doaj.org/article/e444766387db4d569d8f1347652a4e30
Autor:
Daniel Shiloh Malawsky, Seth J. Weir, Jennifer Karin Ocasio, Benjamin Babcock, Taylor Dismuke, Abigail H. Cleveland, Andrew M. Donson, Rajeev Vibhakar, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two m
Externí odkaz:
https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
Autor:
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to
Externí odkaz:
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Jennifer Karin Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c9c57a0e4ea24207a669b99052c30e34
Autor:
Lisa M. Gargano, Robyn R. Gershon, Aminotu Ogunyemi, Danica Dorlette, Lysa J. Petrsoric, James E. Cone
Publikováno v:
Progress in Disaster Science, Vol 4, Iss , Pp - (2019)
A better understanding of the experiences of disaster survivors with post-traumatic stress disorder (PTSD) and serious comorbid medical conditions may lead to improvements in treatment, and help reduce the public health and healthcare burden of affec
Externí odkaz:
https://doaj.org/article/3f172ec7eeb841d38970dafbeb3d578c
Autor:
Timothy R. Gershon, Jeffrey M. Macdonald, Michael D. Taylor, Matthew G. Vander Heiden, Marco A. Marra, Steven J.M. Jones, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Yisu Li, Hedi Liu, Sarah C. Green, Taylor Fish, Jessica Meidinger, A. Sorana Morrissy, Hamza Farooq, Andrey P. Tikunov, Katherine Tech
Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the growth of CGNP-derived m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0953d4b7888e9c257f083e6df8d2e173
https://doi.org/10.1158/0008-5472.c.6508454
https://doi.org/10.1158/0008-5472.c.6508454
Autor:
Timothy R. Gershon, Jeffrey M. Macdonald, Michael D. Taylor, Matthew G. Vander Heiden, Marco A. Marra, Steven J.M. Jones, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Yisu Li, Hedi Liu, Sarah C. Green, Taylor Fish, Jessica Meidinger, A. Sorana Morrissy, Hamza Farooq, Andrey P. Tikunov, Katherine Tech
Immunofluorescence for PKM1 and PCNA demonstrates that PKM1+ cells within medulloblastomas are PCNA-.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffacfc5278336dcd554cfec7207ca1a
https://doi.org/10.1158/0008-5472.22412498
https://doi.org/10.1158/0008-5472.22412498