Zobrazeno 1 - 10
of 25
pro vyhledávání: '"R. Geoffrey Sargent"'
Autor:
Shingo Suzuki, Keisuke Chosa, Cristina Barillà, Michael Yao, Orsetta Zuffardi, Hirofumi Kai, Tsuyoshi Shuto, Mary Ann Suico, Yuet W. Kan, R. Geoffrey Sargent, Dieter C. Gruenert
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Background: Gene correction via homology directed repair (HDR) in patient-derived induced pluripotent stem (iPS) cells for regenerative medicine are becoming a more realistic approach to develop personalized and mutation-specific therapeutic strategi
Externí odkaz:
https://doaj.org/article/98771079d2134f55b64cdc7d8d0cd6f4
Autor:
Shingo Suzuki, R Geoffrey Sargent, Beate Illek, Horst Fischer, Alaleh Esmaeili-Shandiz, Michael J Yezzi, Albert Lee, Yanu Yang, Soya Kim, Peter Renz, Zhongxia Qi, Jingwei Yu, Marcus O Muench, Ashley I Beyer, Alessander O Guimarães, Lin Ye, Judy Chang, Eli J Fine, Thomas J Cradick, Gang Bao, Meghdad Rahdar, Matthew H Porteus, Tsuyoshi Shuto, Hirofumi Kai, Yuet W Kan, Dieter C Gruenert
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a perso
Externí odkaz:
https://doaj.org/article/aa7f6c58c90142c2a88dd3a6fd6f2d5f
Autor:
Dieter C Gruenert, R Geoffrey Sargent
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Externí odkaz:
https://doaj.org/article/9448df6b1e5247ccb7a878e047fcc640
Publikováno v:
Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology: Principles, Delivery and Pharmacological and Biomedical Applications of Nucleotide-Based Therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::439544a817913067978f12e742244b42
https://doi.org/10.1142/9781786346889_0007
https://doi.org/10.1142/9781786346889_0007
Publikováno v:
Nucleic Acids Research. 32:1866-1873
Loss or addition of nucleotides at junctions generated by V(D)J recombination significantly expands the antigen-receptor repertoire. Addition of non-templated (N) nucleotides is carried out by terminal deoxynucleotidyl transferase (TdT), whose only k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf05e6cd2c322db48939c92daf032720
https://doi.org/10.1093/nar/gkh502
https://doi.org/10.1093/nar/gkh502
Autor:
Elizabeth Allen, Christopher Lehman, David A. Zarling, R Geoffrey Sargent, Hong Zeng, Sushma Pati
Publikováno v:
Genomics. 80:543-551
Probing the functional complexity of the human genome will require new gene cloning techniques, not only to discover intraspecies gene homologs and interspecies gene orthologs, but also to identify alternatively spliced gene variants. We report homol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89445a258ec671f3e06daf7f3f12ddf6
https://doi.org/10.1006/geno.2002.6855
https://doi.org/10.1006/geno.2002.6855
Publikováno v:
Methods in Molecular Biology ISBN: 9781627037600
Recent developments in methods to specifically modify genomic DNA using sequence-specific endonucleases and donor DNA have opened the door to a new therapeutic paradigm for cell and gene therapy of inherited diseases. Sequence-specific endonucleases,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928c909f5080eb0ee4327cd5e7572543
https://europepmc.org/articles/PMC4162661/
https://europepmc.org/articles/PMC4162661/
Publikováno v:
Molecular and Cellular Biology. 21:126-135
Telomere repeat sequences cap the ends of eucaryotic chromosomes and help stabilize them. At interstitial sites, however, they may destabilize chromosomes, as suggested by cytogenetic studies in mammalian cells that correlate interstitial telomere se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f9691af34aa336e29afcf8c78b7d5e
https://doi.org/10.1128/mcb.21.1.126-135.2001
https://doi.org/10.1128/mcb.21.1.126-135.2001
Autor:
Gerald M. Adair, R. Geoffrey Sargent, Rodney S. Nairn, James L. Meservy, Brian D. Perkins, Zsofia Intody, John H. Wilson, April E. Kilburn
Publikováno v:
Nucleic Acids Research. 28:3771-3778
Spontaneous recombination between direct repeats at the adenine phosphoribosyltransferase (APRT) locus in ERCC1-deficient cells generates a high frequency of rearrangements that are dependent on the process of homologous recombination, suggesting tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0351fc9bc89559521a66709a3a588a93
https://doi.org/10.1093/nar/28.19.3771
https://doi.org/10.1093/nar/28.19.3771