Zobrazeno 1 - 10
of 921
pro vyhledávání: '"R. Garbarino"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 12-12 (2023)
OBJECTIVES/GOALS: Determine if the Conserved Transcriptional Response to Adversity transcriptomic profile established in primary blood mononuclear cells (PBMC) of chronically stress caregivers, is present in individuals with early Alzheimer’s disea
Externí odkaz:
https://doaj.org/article/4a768e1c70264603be63bce0d733ff71
Autor:
Mitzi M. Gonzales, Valentina R. Garbarino, Erin Pollet, Juan P. Palavicini, Dean L. Kellogg Jr., Ellen Kraig, Miranda E. Orr
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Alzheimer’s disease and related dementias (ADRD) are among the top contributors to disability and mortality in later life. As with many chronic conditions, aging is the single most influential factor in the development of ADRD. Even among older adu
Externí odkaz:
https://doaj.org/article/0beaf9a2d16a4e038cddae96ddea033e
Publikováno v:
Frontiers in Neuroscience, Vol 10 (2016)
The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan >31 years. Intriguingly, fully-grown naked mole-rats (NMRs) exhibit many traits typical of neonatal rodents. However, little is known about NMR growth and maturation, and we
Externí odkaz:
https://doaj.org/article/8536f04f1fa942c7b9def320f1847eb8
Autor:
James L. Kirkland, Tamar Tchkonia, Nicolas Musi, R. C. Petersen, Sudha Seshadri, E. Marques Zilli, Miranda E. Orr, Suzanne Craft, Mitzi M. Gonzales, Valentina R. Garbarino
Publikováno v:
The Journal of Prevention of Alzheimer's Disease
Preclinical studies indicate an age-associated accumulation of senescent cells across multiple organ systems. Emerging evidence suggests that tau protein accumulation, which closely correlates with cognitive decline in Alzheimer’s disease and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654a29b4d0ad115eb7a6a60c7b40ef68
https://pubmed.ncbi.nlm.nih.gov/35098970
https://pubmed.ncbi.nlm.nih.gov/35098970
Autor:
Suzanne Craft, Ali S. Daeihagh, Gregory J. Gillispie, Gagan Deep, Valentina R. Garbarino, Mitzi M. Gonzales, Sudarshan Krishnamurthy, Miranda E. Orr
Publikováno v:
Mech Ageing Dev
The pathogenic processes driving Alzheimer’s disease (AD) are complex. An incomplete understanding of underlying disease mechanisms has presented insurmountable obstacles for developing effective disease-modifying therapies. Advanced chronological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a492cb149a19a262a38b48f3f52569a0
https://pubmed.ncbi.nlm.nih.gov/34687726
https://pubmed.ncbi.nlm.nih.gov/34687726
Publikováno v:
Pharmacological Research. 140:85-99
A variety of human and animal studies support the hypothesis that serotonin (5-hydroxytryptamine or 5-HT) system dysfunction is a contributing factor to the development of autism in some patients. However, many questions remain about how developmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b3193bfe6b5106c7f236fdcb60bd82
https://doi.org/10.1016/j.phrs.2018.07.010
https://doi.org/10.1016/j.phrs.2018.07.010
Autor:
Sydney Tran, Miranda E. Orr, Sudha Seshadri, Nicolas Musi, Valentina R. Garbarino, Jordan E Glassman, James L. Kirkland
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f9bf84f4ec0b7e5f4604480c52d303
https://doi.org/10.1002/alz.047607
https://doi.org/10.1002/alz.047607
Autor:
Georgianna G. Gould, Jannine D. Cody, Valentina R. Garbarino, Marshall T Edwards, Alicia Sanchez, Abigail Brady
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a57d3262e1da8edfcaa146fb7e5ad1a
https://doi.org/10.1096/fasebj.2019.33.1_supplement.501.12
https://doi.org/10.1096/fasebj.2019.33.1_supplement.501.12
Autor:
Corey M. Smolik, Valentina R. Garbarino, Anastassia R. Nelson, Georgianna G. Gould, Taylor A. Santos, Lynette C. Daws, Martin A. Javors, Wynne Q. Zhang
Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dffc36f4b294aa3f53c1e2bb196bf1
https://europepmc.org/articles/PMC6388691/
https://europepmc.org/articles/PMC6388691/
Publikováno v:
Archives of Biochemistry and Biophysics. 576:8-16
The Oxidative Stress Theory of Aging has had tremendous impact in research involving aging and age-associated diseases including those that affect the nervous system. With over half a century of accrued data showing both strong support for and agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a64221db4bef702844a00594f769e9
https://doi.org/10.1016/j.abb.2015.01.029
https://doi.org/10.1016/j.abb.2015.01.029