Zobrazeno 1 - 10
of 64
pro vyhledávání: '"R. G. Vieira"'
Autor:
Elaine C. Petronilho, Guilherme C. de Andrade, Gileno dos S. de Sousa, Fernando P. Almeida, Michelle F. Mota, Ana Vitória dos S. Gomes, Carlos Henrique S. Pinheiro, Mylena C. da Silva, Hiam R. S. Arruda, Mayra A. Marques, Tuane C. R. G. Vieira, Guilherme A. P. de Oliveira, Jerson L. Silva
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract P53 Phase separation is crucial towards amyloid aggregation and p63 and p73 have enhanced expression in tumors. This study examines the phase behaviors of p53, p63, and p73. Here we show that unlike the DNA-binding domain of p53 (p53C), the
Externí odkaz:
https://doaj.org/article/00b9e9a826c54afface84a0c4a7613a7
Publikováno v:
Prion, Vol 18, Iss 1, Pp 68-71 (2024)
ABSTRACTThe history of human prion diseases began with the original description, by Hans Gerhard Creutzfeldt and by Alfons Maria Jakob, of patients with a severe brain disease that included speech abnormalities, confusion, and myoclonus, in a disease
Externí odkaz:
https://doaj.org/article/421b126019d44c0aa4d4b4a3ca0f1ee2
Autor:
Gabriela Assis-de-Lemos, Rayanne Moura-do-Nascimento, Manuela Amaral-do-Nascimento, Ana C. Miceli, Tuane C. R. G. Vieira
Publikováno v:
Brain Sciences, Vol 14, Iss 5, p 413 (2024)
Transmissible Spongiform Encephalopathies (TSEs), including prion diseases such as Bovine Spongiform Encephalopathy (Mad Cow Disease) and variant Creutzfeldt–Jakob Disease, pose unique challenges to the scientific and medical communities due to the
Externí odkaz:
https://doaj.org/article/13fd84e6cf1d47feb55625ab655a3869
Autor:
Cyntia Alves Conceição, Gabriela Assis de Lemos, Caroline Augusto Barros, Tuane C. R. G. Vieira
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
The molecular cause of transmissible spongiform encephalopathies (TSEs) involves the conversion of the cellular prion protein (PrPC) into its pathogenic form, called prion scrapie (PrPSc), which is prone to the formation of amorphous and amyloid aggr
Externí odkaz:
https://doaj.org/article/a7f5fd0b797f4843a3fe17ceee106742
Autor:
Juliana N. Angelli, Yulli M. Passos, Julyana M. A. Brito, Jerson L. Silva, Yraima Cordeiro, Tuane C. R. G. Vieira
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion
Externí odkaz:
https://doaj.org/article/2e745eb959274478866147910581671a
Autor:
Lucas M. Ascari, Stephanie C. Rocha, Priscila B. Gonçalves, Tuane C. R. G. Vieira, Yraima Cordeiro
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, arise from the structural conversion of the monomeric, cellular prion protein (PrPC) into its multimeric scrapie form (PrPSc). These pathologies comprise a group of intra
Externí odkaz:
https://doaj.org/article/10d3f7a077614841a8a2189d71f82f35
Autor:
Breno José Alencar Pires Barbosa, Bruno Batitucci Castrillo, Ricardo Pires Alvim, Marcelo Houat de Brito, Helio R. Gomes, Sônia M. D. Brucki, Jerusa Smid, Ricardo Nitrini, Michele C. Landemberger, Vilma R. Martins, Jerson L. Silva, Tuane C. R. G. Vieira
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The recent development of IQ-CSF, the second generation of real-time quaking-induced conversion (RT-QuIC) using cerebrospinal fluid (CSF), for the diagnosis of Creutzfeldt-Jakob Disease (CJD) represents a major diagnostic advance in the field. Highly
Externí odkaz:
https://doaj.org/article/8c65d22b87614c38a365d242d3cedb4c
Autor:
J. L. Lisboa, M. O. Guimarães, R. G. Vieira-Andrade, F. M. Ferreira, J. Ramos-Jorge, P. M. Zarzar
Publikováno v:
European Archives of Paediatric Dentistry. 24:33-42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14119a6ce7ef0b2a22d10521673a8a25
https://doi.org/10.1007/s40368-022-00752-4
https://doi.org/10.1007/s40368-022-00752-4
Autor:
Guilherme A. P. de Oliveira, Elaine C. Petronilho, Murilo M. Pedrote, Mayra A. Marques, Tuane C. R. G. Vieira, Elio A. Cino, Jerson L. Silva
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 548 (2020)
Despite being referred to as the guardian of the genome, when impacted by mutations, p53 can lose its protective functions and become a renegade. The malignant transformation of p53 occurs on multiple levels, such as altered DNA binding properties, a
Externí odkaz:
https://doaj.org/article/b1b8574dfef640738555278e8f73f986
Autor:
Gileno Dos Santos de Sousa, Adriani L. Felix, Murilo M. Pedrote, Mayra A. Marques, Guilherme Oliveira, Michelle F. Mota, Fernando P. Almeida, Jerson L. Silva, Benjamin Jakobus, Filipe Pereira da Costa, Giulia D. S. Ferretti, Yulli M. Passos, Elaine C Petronilho, Yraima Cordeiro, Tuane C. R. G. Vieira
Publikováno v:
Chemical Science
Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The mechanism of the formation of the aggregates in the nucleus remains uncert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cbcf480fc7cb7038c06fbeedb5514c
https://pubmed.ncbi.nlm.nih.gov/34163823
https://pubmed.ncbi.nlm.nih.gov/34163823