Výsledky vyhledávání - "R. G. Simmonds"

Synthesis of disulfide-bridged fragments of omega-conotoxins GVIA and MVIIA. Use of Npys as a protecting/activating group for cysteine in Fmoc syntheses

Autor: R G, Simmonds, D E, Tupper, J R, Harris

Publikováno v: International journal of peptide and protein research. 43(4)

The 3-nitro-2-pyridinesulphenyl (Npys) moiety is finding increasing utility as a protecting-activating group for cysteine, particularly in the synthesis of cyclic and unsymmetrical disulfides using the Boc strategy. This chemistry has been extended t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc8425c9ff2ee284c19c98e24562c6ac
https://pubmed.ncbi.nlm.nih.gov/8045682

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A vindesine-anti-CEA conjugate cytotoxic for human cancer cells in vitro

Autor: C.S. Woodhouse, C.H.J. Ford, C.E. Newman, R G Simmonds, G F Rowland, J R Johnson

Publikováno v: British Journal of Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8503ede4f1ffdcc105fc1d730d926b3c
https://doi.org/10.1038/bjc.1981.209

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Localisation and toxicity study of a vindesine-anti-CEA conjugate in patients with advanced cancer

Autor: G F Rowland, C.H.J. Ford, C.E. Newman, T A Reeder, C.S. Woodhouse, J R Johnson, R G Simmonds

Publikováno v: British Journal of Cancer

Safety of administration of a vindesine (VDS)-anti-CEA conjugate and its ability to localise after radiolabelling were investigated in patients with advanced metastatic carcinoma (4 colorectal and 4 ovarian). For imaging, patients received between 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19728f58433c04dd8a467eb03d56ee6
http://europepmc.org/articles/PMC2011264

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Synthesis of some phenanthridone derivatives

Autor: J. W. James, R. F. Cookson, R. E. Rodway, R. G. Simmonds

Publikováno v: Journal of Heterocyclic Chemistry. 9:475-480

The alkylation of phenanthridone and some nuclear-substituted phenanthridones using sodium hydride in DMF/benzene is reported. Various 5-cyanoalkylphenanthridones were converted to further derivatives by either hydrolysis or reduction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa30d304d154da73b1af0f0acfef4289
https://doi.org/10.1002/jhet.5570090303

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Experience in the preparation and experimental use of immunocytostatics

Autor: M J, Embleton, M V, Pimm, M C, Garnett, G F, Rowland, R G, Simmonds, R W, Baldwin

Publikováno v: Behring Institute Mitteilungen. (74)

Vindesine (VDS) was coupled directly to a monoclonal antibody (791T/36) raised against a human osteogenic sarcoma cell line, and methotrexate (MTX) was coupled to 791T/36 via an intervening human serum albumin (HSA) bridge. Both the VDS-791T/36 and M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d52d08470039f7310b5d563ceb94de0
https://pubmed.ncbi.nlm.nih.gov/6591915

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ChemInform Abstract: SYNTH. EINIGER PHENANTHRIDON-DERIVATE

Autor: J. W. James, R. G. Simmonds, R. F. Cookson, R. E. Rodway

Publikováno v: Chemischer Informationsdienst. 3

Phenanthridon (I) liefert uber das Anion das N-Cyanathylderivat (IIb) und die analogen Nitrile (IIa) und (IIc), aus denen die Amine (III), deren Acetate (IV), die Amide (V), die Ester (VI) und die Carbonsauren (VII) sowie das spezielle Cyclisierungsp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0103864ad6c0596eef02abac65ee4cd3
https://doi.org/10.1002/chin.197245302

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