Zobrazeno 1 - 8
of 8
pro vyhledávání: '"R. G. Melik-Ohanjanyan"'
Autor:
F. G. Arsenyan, T. R. Ovsepyan, N. S. Minasyan, S. V. Dilanyan, R. E. Muradyan, R. G. Melik-Ohanjanyan
Publikováno v:
Pharmaceutical Chemistry Journal. 52:404-407
3,4-Substituted-(4H)-1,2,4-triazole-5-thiols were synthesized and used for S-alkylation, cyanoethylation, and aminomethylation to produce a series of new 1,2,4-triazole derivatives of interest as biologically active compounds. The antitumor propertie
Autor:
G. A. Panosyan, R. G. Melik-Ohanjanyan, T. R. Hovsepyan, L. E. Nersesyan, S. G. Israelyan, G. S. Karakhanyan
Publikováno v:
Russian Journal of Organic Chemistry. 54:107-111
One-step three-component cyclocondensation of 2,6-disubstituted pyrimidin-4(3H)-ones with 1,3-dicarbonyl compounds and some aromatic and heterocyclic aldehydes on heating or under microwave irradiation afforded new functionally substituted 5,8-dihydr
Publikováno v:
Pharmaceutical Chemistry Journal. 51:760-763
Cyclization of substituted thiosemicarbazides in alkaline medium was used to synthesize the corresponding 3-thio-4-benzyl(cyclohexyl, allyl)-5-(4-benzyloxyphenyl)-1,2,4-triazoles. These compounds were 3-S-alkylated with ethylene chlorohydrin, chloroa
Publikováno v:
Russian Journal of General Chemistry. 86:1845-1849
2-Substituted 1,3,4-thiadiazole-5-thiol has been synthesized basing on hydrazide of 3-methoxy-phenoxyacetic acid. Methods of SH-alkylation, aminomethylation, and cyanoethylation of the product have been elaborated. Reactions of the starting hydrazide
Autor:
A. G. Ayvazyan, Rafael Tamazyan, M. S. Ghukasyan, R. G. Melik-Ohanjanyan, T. R. Hovsepyan, S. G. Israelyan, G. S. Karakhanyan, Henry A. Panosyan
Publikováno v:
Russian Journal of Organic Chemistry. 51:361-367
New acyclic pyrimidine nucleosides, analogs of the antiviral drug acyclovir, were synthesized starting from 6-chloropyrimidine-2,4(1H,3H)-dione. The addition of side carbohydrate chain to the N1 or N3 atoms of the heterocyclic base with formation of
Publikováno v:
Russian Journal of Organic Chemistry. 50:736-741
Intermolecular cyclization of 1-phenyl(benzyl, allyl)-4-(4-methoxybenzyl- or 3-chloro-4-methoxybenzyl) thiosemicarbazides afforded the corresponding 3,4,5-substituted 4H-1,2,4-triazoles. Reactions of Salkylation and aminomethylation of the latter wer
Autor:
R. G. Melik-Ohanjanyan, Rafael Tamazyan, S. G. Israelyan, M. R. Hakobyan, T. R. Hovsepyan, A. G. Ayvazyan
Publikováno v:
Russian Journal of Organic Chemistry. 50:913-915
Publikováno v:
Chemistry of Heterocyclic Compounds. 44:1395-1397
We have already reported the synthesis of substituted 1,2,4-triazoles and 1,3,4-thiadiazoles [1], which have a broad spectrum of biological activity as it known from the literature data. Continuing a search for biologically active compounds of this t