Výsledky vyhledávání

VH Mutant Rabbits Lacking the VH1a2 Gene Develop a2+ B Cells in the Appendix by Gene Conversion-Like Alteration of a Rearranged VH4 Gene

Autor: D, Sehgal, R G, Mage, E, Schiaffella

Publikováno v: The Journal of Immunology. 160:1246-1255

We investigated the molecular basis for the appearance of VHa2 allotype-bearing B cells in mutant Alicia rabbits. The mutation arose in an a2 rabbit; mutants exhibit altered expression of VH genes because of a small deletion encompassing VH1a2, the 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeba1e2c3c267c95150383898e01a1a0
https://doi.org/10.4049/jimmunol.160.3.1246

Zobrazit plný text záznamu

RAG1 and RAG2 in developing rabbit appendix subpopulations

Autor: P Fuschiotti, M G Fitts, R Pospisil, P D Weinstein, R G Mage

Publikováno v: The Journal of Immunology. 158:55-64

The appendix of young rabbits is a site of primary heavy chain variable region-gene diversification and B cell selection. Appendix cells from 6- to 9-wk-old rabbits were stained and sorted for surface CD43 and IgM. We found that the CD43+IgM- and dou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb4f15901243beee91cabd24061036cf
https://doi.org/10.4049/jimmunol.158.1.55

Zobrazit plný text záznamu

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits

Autor: H T Chen, C B Alexander, R G Mage

Publikováno v: The Journal of Immunology. 154:6365-6371

Normal rabbits preferentially rearrange the 3'-most VH gene, VH1, to encode Igs with VHa allotypes, which constitute the majority of rabbit serum Igs. A gene conversion-like mechanism is employed to diversify the primary Ab repertoire. In mutant Alic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4990c5fe27fe095d978391adb58d88df
https://doi.org/10.4049/jimmunol.154.12.6365

Zobrazit plný text záznamu

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression

Autor: H T Chen, C B Alexander, G O Young-Cooper, R G Mage

Publikováno v: The Journal of Immunology. 150:2783-2793

Rabbits of the Alicia strain, derived from rabbits expressing the VHa2 allotype, have a mutation in the H chain locus that has a cis effect upon the expression of VHa2 and VHa- genes. A small deletion at the most J-proximal (3') end of the VH locus l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37b9ba4c147e1a2d41c2db738e72bc65
https://doi.org/10.4049/jimmunol.150.7.2783

Zobrazit plný text záznamu

Identification of enhancer sequences 3' of the rabbit Ig kappa L chain loci

Autor: N J Hole, N Harindranath, G O Young-Cooper, R Garcia, R G Mage

Publikováno v: The Journal of Immunology. 146:4377-4384

The rabbit is useful for studies of Ig L chain gene expression because of a great disparity in expression of two isotypic forms of the kappa L chain. Normally, K1 is expressed at high levels and K2 is almost silent; expression of K2 increases in muta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f8d4c93c71963e9aa4bbe51a333cc1f
https://doi.org/10.4049/jimmunol.146.12.4377

Zobrazit plný text záznamu

Declawing of neonatal rabbits destined for use in animal biosafety level 4 containment studies

Autor: K A, Perdue, R E, Shaw, R G, Mage

Publikováno v: Contemporary topics in laboratory animal science. 39(3)

To protect personnel and protective outerwear from damage by scratching, rabbits to be housed in an Animal Biosafety Level 4 (ABSL4) facility are declawed routinely. The objective of the study presented here was to establish a procedure for declawing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e88b58d2a5a8144902c43831ed6a673
https://pubmed.ncbi.nlm.nih.gov/11178319

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání