Zobrazeno 1 - 10
of 11
pro vyhledávání: '"R. G. Charlton"'
Publikováno v:
Scopus-Elsevier
Objective: Because angiogenesis and inflammation are intimately associated and endoglin is required for angiogenesis, we wished to determine whether it also plays a role in inflammation.¶Methods: Using an immunohistochemical approach, we examined sp
Publikováno v:
BJU International. 84:953-960
Objective To compare and quantify, in a morphological study, the changes that occur in the connective tissue elements (elastin and collagen), muscle fibre diameters and nerve densities between normal, idiopathic and neuropathic bladders. Materials an
Publikováno v:
British Journal of Cancer
Vascular endothelial growth factor (VEGF) mediates neo-angiogenesis during tumour progression and is known to cooperate with the fibroblast growth factor (FGF) system to facilitate angiogenesis in a synergistic manner. In view of this, we have invest
Autor:
R. G. Charlton, Helen M. Arthur, Austin G. Diamond, Andrew J.H. Smith, Glenn L. Renforth, Trevor Jowett, D V Parums, Douglas A. Marchuk, Jan Ure, John Burn, Evelyn Torsney, David I. Wilson
Publikováno v:
Developmental Biology. 217(1):42-53
Endoglin (CD105) is expressed on the surface of endothelial and haematopoietic cells in mammals and binds TGFbeta isoforms 1 and 3 in combination with the signaling complex of TGFbeta receptors types I and II. Endoglin expression increases during ang
Autor:
NM Walter, Max Robinson, R. G. Charlton, David E. Neal, JA Royds, Freddie C. Hamdy, I. Apakama, CE Fuller
Publikováno v:
British Journal of Cancer
Seventy-seven men with histologically proven and newly diagnosed prostate cancer we investigated for the presence of bcl-2 protein overexpression and p53 protein accumulation 1 immunohistochemistry. Forty-five men had evidence of locally advanced and
Publikováno v:
British Journal of Urology. 73:533-537
Objective To investigate a potential role for overexpres-sion of the p53 protein in the identification of pTl bladder tumours destined to progress. Patients and methods The protein expression of the tumour suppressor gene p53, nuclear ploidy and tumo
Autor:
Austin G. Diamond, Helen M. Arthur, R. G. Charlton, James V. Soames, John Burn, Evelyn Torsney
Publikováno v:
Circulation. 107(12)
Background— Mutations in endoglin or activin like kinase-1, both involved in the endothelial transforming growth factor-β signaling pathway, cause the autosomal dominant bleeding disorder hereditary hemorrhagic telangiectasia. We and others have r
Publikováno v:
BJU international. 84(9)
To compare and quantify, in a morphological study, the changes that occur in the connective tissue elements (elastin and collagen), muscle fibre diameters and nerve densities between normal, idiopathic and neuropathic bladders.Bladder tissue was obta
Publikováno v:
British Journal of Urology. 60:399-404
A histochemical study of lectin binding was performed to assess staining with lectins and, therefore, the expression of complex carbohydrates in human neoplastic urothelium. Forty-seven patients with transitional cell carcinoma of the bladder and six
Publikováno v:
Scopus-Elsevier
Mutation of the p53 gene is one of the commonest genetic abnormalities found in solid human tumours. This gene is probably concerned with the control of cellular proliferation and in view of this we carried out a study of human prostate cancer and be
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