Zobrazeno 1 - 10
of 75
pro vyhledávání: '"R. Fruchtmann"'
Publikováno v:
Zentralblatt für Veterinärmedizin Reihe B. 24:486-496
Zusammenfassung 1. Die Isolierung von Lymphozyten aus Rinderblut erfolgte nach Defibrinierung und Entfernung der Thrombozyten im Uromiro-Dichtegradienten. Die Ausbeute betrug 53, 94% bei einem Reinheitsgrad von 99,6%. 2. Die T-Lymphozyten des Rindes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2441d084951fe15532a1379bd9509127
https://doi.org/10.1111/j.1439-0450.1977.tb01017.x
https://doi.org/10.1111/j.1439-0450.1977.tb01017.x
Autor:
J. Goossens, S. Raddatz, K. H. Mohrs, Reiner Muller-Peddinghaus, R. Fruchtmann, Hatzelmann Armin
Publikováno v:
Biochemical Pharmacology. 47:2259-2268
A series of quinoline derivatives were analysed for the influence on leukotriene synthesis as a parameter for 5-LOX (EC 1.13.11.34) activity in a cell-free system of the 10,000 g supernatant of human PMNL (polymorphonuclear leukocytes). The ratios of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5424d95ea53c9a159ca8f36387b0e62f
https://doi.org/10.1016/0006-2952(94)90264-x
https://doi.org/10.1016/0006-2952(94)90264-x
Autor:
Hatzelmann Armin, S. Raddatz, R. Fruchtmann, Bodo Junge, K. H. Mohrs, Reiner Muller-Peddinghaus, H. Horstmann, Burkhard Fugmann
Publikováno v:
Agents and Actions. 38:188-195
BAY X1005, (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid, is an enantioselective inhibitor of leukotriene biosynthesis. It effectively inhibits the synthesis of LTB4 in A23187-stimulated leukocytes from rats, mice and humans (IC50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf118e4bf84ccda403e281988a4b32e
https://doi.org/10.1007/bf01976210
https://doi.org/10.1007/bf01976210
Autor:
Hatzelmann Armin, R. Kupferschmidt, K. H. Mohrs, R. Fruchtmann, Reiner Muller-Peddinghaus, R. Kast, S. Raddatz
Publikováno v:
Agents and Actions. 41:C166-C168
Using intact and fractionated human polymorphonuclear leukocytes (PMNL), we provide evidence that the enantioselective leukotriene synthesis inhibitor (LSI) BAY X 1005, (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid binds specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c570f80db31d38b634b0f42bcce6047
https://doi.org/10.1007/bf01987624
https://doi.org/10.1007/bf01987624
Autor:
S. Raddatz, U. Pleiss, J. Keldenich, Hatzelmann Armin, M. Matzke, Reiner Muller-Peddinghaus, R. Fruchtmann, K. H. Mohrs
Publikováno v:
Agents and actions. 43(1-2)
Five-lipoxygenase (5-LOX) inhibition is gaining increasing importance as a novel approach to therapy of allergic asthma and other inflammatory diseases. Presently, two types of inhibitors are known, direct 5-LOX inhibitors (LOI) and the FLAP (five li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5261a01904857409080108b1c44c3668
https://pubmed.ncbi.nlm.nih.gov/7741044
https://pubmed.ncbi.nlm.nih.gov/7741044
Publikováno v:
Biochemical pharmacology. 48(1)
The mode of action of the new leukotriene synthesis inhibitor BAY X1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally-related quinoline derivatives is reflected by the binding to a high-affinity binding site pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f47036b1d1948f5b963f4d913b09b1
https://pubmed.ncbi.nlm.nih.gov/8043028
https://pubmed.ncbi.nlm.nih.gov/8043028
Autor:
A, Hatzelmann, R, Fruchtmann, K H, Mohrs, S, Raddatz, M, Matzke, U, Pleiss, J, Keldenich, R, Müller-Peddinghaus
Publikováno v:
Advances in prostaglandin, thromboxane, and leukotriene research. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3c52692ae68b52ab1099567a484d19c
https://pubmed.ncbi.nlm.nih.gov/7771337
https://pubmed.ncbi.nlm.nih.gov/7771337
Autor:
R, Müller-Peddinghaus, C, Kohlsdorfer, P, Theisen-Popp, R, Fruchtmann, E, Perzborn, B, Beckermann, K, Bühner, H J, Ahr, K H, Mohrs
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(1)
(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) (BAY X1005) is an orally active inhibitor of the synthesis of the leukotrienes B4 and C4 in selected animal models that effectively reduces the vascular phenomena of inflammation, i.e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11f0200f73becd057c2726669a42f18d
https://pubmed.ncbi.nlm.nih.gov/8229782
https://pubmed.ncbi.nlm.nih.gov/8229782
Autor:
R, Müller-Peddinghaus, R, Fruchtmann, H J, Ahr, B, Beckermann, K, Bühner, B, Fugmann, B, Junge, M, Matzke, C, Kohlsdorfer, S, Raddatz
Publikováno v:
Journal of lipid mediators. 6(1-3)
The enantiomer BAY X1005 [(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid] potently inhibits LTB4 synthesis in isolated PMNL of various species (IC50 mumol/l, human 0.22, rat 0.026, mouse 0.039) and LTC4 synthesis in mouse macrophag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa1e9a1f5e36a23a0882702ea1e66dd
https://pubmed.ncbi.nlm.nih.gov/8395246
https://pubmed.ncbi.nlm.nih.gov/8395246
Publikováno v:
Biochemical pharmacology. 45(1)
BAY X 1005 (R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid has been demonstrated to be a potent inhibitor of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) synthesis in various in vitro systems. Using mainly human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d1b078203dd9c96462633f8e051e96
https://pubmed.ncbi.nlm.nih.gov/8381000
https://pubmed.ncbi.nlm.nih.gov/8381000