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Crystal structures and pharmacological activity of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-(unsubstituted, 3-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl)-1,4-dihydropyridine

Autor: C. Romming, R. Fossheim, K. Svarteng, E. Shefter, D J Triggle, A. Mostad

Publikováno v: Journal of Medicinal Chemistry. 25:126-131

The molecular structures of 2,6-dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine and the 3-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl derivatives were determined by X-ray diffraction methods. The dihydropyridine ring in eac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0524ee2972b6b4bfd82e39af0516b0e7
https://doi.org/10.1021/jm00344a007

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Crystal structures and pharmacologic activities of 1,4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2,6-dimethyl-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nisoldipine) series

Autor: A. J. Solo, E. Luchowski, David J. Triggle, A. Rutledge, R. Fossheim, A. Joslyn

Publikováno v: Journal of Medicinal Chemistry. 31:300-305

A series of isobutyl methyl 2,6-dimethyl-4-(X-substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylates (X = H, 2-NO2, 3-NO2, 3-CN, 3-MeO, 4-F, 2-CF3, 3-CF3, and 4-Cl) related to and including nisoldipine (X = 2-NO2) has been synthesized, their soli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4738cb0e3e494317e81d41c15dcc81
https://doi.org/10.1021/jm00397a005

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ChemInform Abstract: Crystal Structure of a 1,4-Dihydropyridine with Enantiomers Showing Opposite Effects on Calcium Channels: Structural Features of Calcium Channel Agonists and Antagonists

Autor: R. Fossheim

Publikováno v: ChemInform. 19

The structure of the calcium channel modulator isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-5-nitro- 3-pyridinecarboxylate has been determined by X-ray analysis. Structural and stereochemical features are discussed in relation to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34d76d1a4b9bc65e7d3d7aeb814d0201
https://doi.org/10.1002/chin.198808052

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Crystal structure of the dihydropyridine Ca2+ antagonist felodipine. Dihydropyridine binding prerequisites assessed from crystallographic data

Autor: R, Fossheim

Publikováno v: Journal of medicinal chemistry. 29(2)

The molecular structure of the dihydropyridine Ca2+ antagonist felodipine (ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxy late) has been determined by X-ray crystallographic methods. The dihydropyridine ring in thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70cba4681ca607abcaee0d9f69ee09f6
https://pubmed.ncbi.nlm.nih.gov/3005572

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Crystal structures and pharmacological activity of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-(unsubstituted, 2-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl)-1,4-dihydropyridine

Autor: R, Fossheim, K, Svarteng, A, Mostad, C, Rømming, E, Shefter, D J, Triggle

Publikováno v: Journal of medicinal chemistry. 25(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ada003f8e7e2ad67029040df9bd0c12
https://pubmed.ncbi.nlm.nih.gov/7057416

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