Zobrazeno 1 - 10
of 1 544
pro vyhledávání: '"R. Flynn"'
Autor:
Avnish Patel, Aline Fréville, Joshua A. Rey, Helen R. Flynn, Konstantinos Koussis, Mark J. Skehel, Michael J. Blackman, David A. Baker
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falcipar
Externí odkaz:
https://doaj.org/article/8e1daffe95784ff5ad6aba222b2a6941
Autor:
Brandon L. Southall, John W. Durban, John Calambokidis, Caroline Casey, James A. Fahlbusch, Holly Fearnbach, Kiirsten R. Flynn, Selene Fregosi, Ari S. Friedlaender, Samantha G. M. Leander, Fleur Visser
Publikováno v:
Royal Society Open Science, Vol 11, Iss 10 (2024)
Despite strong interest in how noise affects marine mammals, little is known for the most abundant and commonly exposed taxa. Social delphinids occur in groups of hundreds of individuals that travel quickly, change behaviour ephemerally and are not a
Externí odkaz:
https://doaj.org/article/d5177e7bc3fa4624a72254bf095d36c7
Autor:
Doris Leithner, Jessica R. Flynn, Sean M. Devlin, Audrey Mauguen, Teng Fei, Shang Zeng, Junting Zheng, Brandon S. Imber, Harper Hubbeling, Marius E. Mayerhoefer, Akshay Bedmutha, Efrat Luttwak, Magdalena Corona, Parastoo B. Dahi, Alejandro Luna de Abia, Ivan Landego, Richard J. Lin, M. Lia Palomba, Michael Scordo, Jae H. Park, Ana Alarcon Tomas, Gilles Salles, Daniel Lafontaine, Laure Michaud, Gunjan L. Shah, Miguel-Angel Perales, Roni Shouval, Heiko Schöder
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-5 (2024)
Abstract Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma (LBCL), yet biomarkers that predict outcomes and toxicity are lacking. We examined radiomic features extracted from pr
Externí odkaz:
https://doaj.org/article/1e910f54afef407eafa80437985cb2a3
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Ohad Benjamini, Shalev Fried, Roni Shouval, Jessica R. Flynn, Ofrat Beyar-Katz, Lori A Leslie, Tsilla Zucherman, Ronit Yerushalmi, Noga Shem-Tov, Maria Lia Palomba, Ivetta Danylesko, Inbal Sdayoor, Hila Malka, Orit Itzhaki, Hyung Suh, Sean M. Devlin, Ronit Marcus, Parastoo B Dahi, Elad Jacoby, Gunjan L Shah, Craig S Sauter, Andrew Ip, Miguel-Angel Perales, Arnon Nagler, Avichai Shimoni, Michael Scordo, Abraham Avigdor
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
The activity of anti-CD19 CAR T cell therapy in chronic lymphocytic leukemia (CLL) with Richter's transformation (RT) to aggressive large B cell lymphoma (LBCL) is largely unknown. In a multicenter retrospective study, we report the safety and effica
Externí odkaz:
https://doaj.org/article/446c107a98b1415f962e7e3be018edfa
Autor:
Jianzhi Jiang, Brent Wilkinson, Ilse Flores, Nicolas Hartel, Simeon R. Mihaylov, Veronica A. Clementel, Helen R. Flynn, Fowsan S. Alkuraya, Sila Ultanir, Nicholas A. Graham, Marcelo P. Coba
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD) signaling hub, with many variants reported in neurod
Externí odkaz:
https://doaj.org/article/71c2f47483de4fde9adf3e8577e72175
Autor:
Simeon R. Mihaylov, Lydia M. Castelli, Ya-Hui Lin, Aytac Gül, Nikita Soni, Christopher Hastings, Helen R. Flynn, Oana Păun, Mark J. Dickman, Ambrosius P. Snijders, Robert Goldstone, Oliver Bandmann, Tatyana A. Shelkovnikova, Heather Mortiboys, Sila K. Ultanir, Guillaume M. Hautbergue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract PGC-1α plays a central role in maintaining mitochondrial and energy metabolism homeostasis, linking external stimuli to transcriptional co-activation of genes involved in adaptive and age-related pathways. The carboxyl-terminus encodes a se
Externí odkaz:
https://doaj.org/article/d4c65c08085643d58fc9598614996598
Autor:
Calvin R. Flynn, Shun-Chieh Liu, Berbie Byrne, James Ralph, Gabriela Paz, Salman Anwar, Jemma Buchalter, Orla M. Fitzpatrick, Trevor Markham, Paul Donnellan
Publikováno v:
Case Reports in Oncology, Vol 16, Iss 1, Pp 652-661 (2023)
Apalutamide is a novel nonsteroidal androgen receptor inhibitor that has been shown to improve outcomes for patients with nonmetastatic castration-resistant prostate cancer and metastatic castration-sensitive prostate cancer when combined with androg
Externí odkaz:
https://doaj.org/article/094c1f451ec946248b136fe7be931845
Autor:
Ted Cheeseman, Jay Barlow, Jo Marie Acebes, Katherina Audley, Lars Bejder, Caitlin Birdsall, Olga Solis Bracamontes, Amanda L. Bradford, Josie Byington, John Calambokidis, Rachel Cartwright, Jen Cedarleaf, Andrea Jacqueline García Chavez, Jens Currie, Rouenne Camille De Castro, Joëlle De Weerdt, Nicole Doe, Thomas Doniol-Valcroze, Karina Dracott, Olga Filatova, Rachel Finn, Kiirsten R. Flynn, John Ford, Astrid Frisch-Jordán, Chris Gabriele, Beth Goodwin, Craig Hayslip, Jackie Hildering, Marie C. Hill, Jeff K. Jacobsen, M. Esther Jiménez-López, Meagan Jones, Nozomi Kobayashi, Marc Lammers, Edward Lyman, Mark Malleson, Evgeny Mamaev, Pamela Martínez Loustalot, Annie Masterman, Craig O. Matkin, Christie McMillan, Jeff Moore, John Moran, Janet L. Neilson, Hayley Newell, Haruna Okabe, Marilia Olio, Christian D. Ortega-Ortiz, Adam A. Pack, Daniel M. Palacios, Heidi Pearson, Ester Quintana-Rizzo, Raul Ramírez Barragán, Nicola Ransome, Hiram Rosales-Nanduca, Fred Sharpe, Tasli Shaw, Ken Southerland, Stephanie Stack, Iain Staniland, Janice Straley, Andrew Szabo, Suzie Teerlink, Olga Titova, Jorge Urban-Ramirez, Martin van Aswegen, Marcel Vinicius, Olga von Ziegesar, Briana Witteveen, Janie Wray, Kymberly Yano, Igor Yegin, Denny Zwiefelhofer, Phil Clapham
Publikováno v:
Royal Society Open Science, Vol 11, Iss 2 (2024)
For the 40 years after the end of commercial whaling in 1976, humpback whale populations in the North Pacific Ocean exhibited a prolonged period of recovery. Using mark–recapture methods on the largest individual photo-identification dataset ever a
Externí odkaz:
https://doaj.org/article/8dfc3af60f5e4c58ada854a50774f5d2
Autor:
Cassandra L. Martin, Kaitlyn R. Flynn, Taehwan Kim, Skyler K. Nikolic, Leila F. Deravi, Daniel J. Wilson
Publikováno v:
Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)
Abstract Modern paints and coatings are designed for a variety of applications, ranging from fine art to extraterrestrial thermal control. These systems can be engineered to provide lasting color, but there are a limited number of materials that can
Externí odkaz:
https://doaj.org/article/34eb50cc160643c98e1ec8655e2d493d