Zobrazeno 1 - 10
of 574
pro vyhledávání: '"R. Fehr"'
Publikováno v:
Pathogens, Vol 12, Iss 10, p 1221 (2023)
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose bin
Externí odkaz:
https://doaj.org/article/6f5e6615ca144d4793a7b380b4af50a9
Autor:
Cindy Y. Ly, Jessica Pfannenstiel, Anil Pant, Zhilong Yang, Anthony R. Fehr, Maxim S. Rodzkin, David J. Davido
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT We utilized a high-throughput cell-based assay to screen several chemical libraries for inhibitors of herpes simplex virus 1 (HSV-1) gene expression. From this screen, four aurora kinase inhibitors were identified that potently reduced gene
Externí odkaz:
https://doaj.org/article/7f189312271f454290d415a1f257e4c8
Autor:
Joseph J. O’Connor, Lynden Voth, Jeremiah Athmer, Nicholas M. George, Christopher M. Connelly, Anthony R. Fehr
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1082 (2023)
The continued circulation of SARS-CoV-2 and the increasing frequency of coronavirus (CoV) outbreaks over the decades demonstrates the enduring threat that the CoV family poses. There remains a significant need to develop tools to monitor and prevent
Externí odkaz:
https://doaj.org/article/43672355203640b384d89a8a2fa20a3a
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010535 (2022)
Externí odkaz:
https://doaj.org/article/82145e4f6bb1406ea2475e7b716c0b81
Publikováno v:
Pathogens, Vol 11, Iss 1, p 94 (2022)
Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonst
Externí odkaz:
https://doaj.org/article/ed48111fe8204080a38d03ee82583188
Autor:
Matthew E Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S Sullivan, Stanley Perlman, Anthony R Fehr
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007756 (2019)
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs. While several PARPs
Externí odkaz:
https://doaj.org/article/3626d2ff4f4b4dbeb2b06ed5db5433f6
Autor:
Yousef M. Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Joseph J. O’Connor, Catherine M. Kerr, Jessica J. Pfannenstiel, Debarati Chanda, Caden A. Miller, Robert L. Unckless, Sonia Zuniga, Luis Enjuanes, Sunil More, Rudragouda Channappanavar, Anthony R. Fehr
Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de8f7884609360a09184a0574459cb07
https://doi.org/10.1101/2023.04.06.535927
https://doi.org/10.1101/2023.04.06.535927
Autor:
Yousef M. O. Alhammad, Anthony R. Fehr
Publikováno v:
Viruses, Vol 12, Iss 4, p 384 (2020)
Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection. ADP-ribose is covalently attached to target proteins by pol
Externí odkaz:
https://doaj.org/article/ca6378be516345229c5b67a2bee63c03
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon Responses
Autor:
Jeremiah Athmer, Anthony R. Fehr, Matthew E. Grunewald, Wen Qu, D. Lori Wheeler, Kevin W. Graepel, Rudragouda Channappanavar, Aimee Sekine, Dana Saud Aldabeeb, Michael Gale, Mark R. Denison, Stanley Perlman
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Selective packaging is a mechanism used by multiple virus families to specifically incorporate genomic RNA (gRNA) into virions and exclude other types of RNA. Lineage A betacoronaviruses incorporate a 95-bp stem-loop structure, the packaging
Externí odkaz:
https://doaj.org/article/3da1a93d54de4efbb6a33718ce452b29
Autor:
Javier Canton, Anthony R Fehr, Raúl Fernandez-Delgado, Francisco J Gutierrez-Alvarez, Maria T Sanchez-Aparicio, Adolfo García-Sastre, Stanley Perlman, Luis Enjuanes, Isabel Sola
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006838 (2018)
Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%. When expressed in isolation, CoV ac
Externí odkaz:
https://doaj.org/article/a542e05c086a41129590f7a21c0b21a1