Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R. F. Valeev"'
Publikováno v:
Russian Journal of Organic Chemistry. 57:889-904
A new chiral 10,11-didehydro analog of epothilone D with isosteric substitution in the C15–C3 fragment of natural epothilones has been synthesized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe352f286200121163a33a25fb4c471
https://doi.org/10.1134/s1070428021060038
https://doi.org/10.1134/s1070428021060038
Publikováno v:
Russian Journal of Organic Chemistry. 56:1140-1145
Yamaguchi esterification of (2Z,5S,6E)-5-(hydroxymethyl)-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienal with (2R,5R,6S,7S)-2-(methoxymethoxy)-3,3,5,7-tetramethyl-4-oxo-9-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl-6-[(triethylsilyl)oxy]nonanoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5a6135fd0687396f8a11bea972e2cb8
https://doi.org/10.1134/s1070428020070039
https://doi.org/10.1134/s1070428020070039
Publikováno v:
Russian Journal of Organic Chemistry. 55:1370-1373
A synthetic approach is described for the transformation of R-(-)-carvone to methyl (2Z,5S,6E)-5-[(tert-butoxycarbonyl)amino]-2,6-dimethyl-7-(2-methyl-1,3-thiazol-4-yl)hepta-2,6-dienoate, the key building block for the convergent synthesis of the kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::042dc19648a242a4c60cbd26b613a36a
https://doi.org/10.1134/s1070428019090161
https://doi.org/10.1134/s1070428019090161
Publikováno v:
Russian Journal of Organic Chemistry. 54:1548-1552
The synthesis of acyclic precursors to epothilone D analogs has been explored. Optimal conditions have been found for enolization of (1R)-1-(1,3-dithiolan-2-yl)-1-(methoxymethoxy)-2,2-dimethylpentan-3-one and its aldol condensation with C6‒C21 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684cd489d6b8c07c6a76efed25cbf788
https://doi.org/10.1134/s1070428018100172
https://doi.org/10.1134/s1070428018100172
Publikováno v:
Russian Journal of Organic Chemistry. 55:1439-1441
Coupling of previously synthesized chiral building blocks via Yamaguchi esterification has been studied with the goal of obtaining epothilone D isosteres. Some peculiar features of the Yamaguchi esterification stage have been revealed, which are rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1375eeeaa9972edf74489f7593f861e
https://doi.org/10.1134/s1070428019090264
https://doi.org/10.1134/s1070428019090264
Publikováno v:
Russian Journal of Organic Chemistry. 53:1687-1690
Synthesis was developed of a new chiral block for epothilone analogs from R-(‒)-pantolactone.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ddb40ad2d5fcc6d29b6fa717fca2592
https://doi.org/10.1134/s1070428017110136
https://doi.org/10.1134/s1070428017110136
Publikováno v:
Russian Journal of Organic Chemistry. 51:660-663
New procedure was developed for preparation of the fragment C10-C21 of epothilone D analog from R-(-)-carvone. The key stage of the synthesis consists in the regio- and stereoselective Wittig reaction of (5R)-5-acetyl-2-methylcyclohex-2-en-1-one with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3b2b81d0ca0b51e3c6b754ce12369dd
https://doi.org/10.1134/s1070428015050139
https://doi.org/10.1134/s1070428015050139
Publikováno v:
Russian Journal of Organic Chemistry. 50:1511-1519
A promising potentially biologically active structure have been designed by isosteric rearrangement of the C15−C3 fragment of epothilone D, and building blocks necessary for its assembly have been synthesized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bf22977f827a39e1bd766e0f661b4b7
https://doi.org/10.1134/s1070428014100170
https://doi.org/10.1134/s1070428014100170
Publikováno v:
Mendeleev Communications. 28:587-588
Condensation of separately obtained C1–C9 and C10–C21 chiral blocks under Yamaguchi conditions affords the corresponding ester, an acyclic precursor of an epothilone D analogue. The reaction is accompanied by the formation of a side product of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3ed332aaf537c4889b43368e138d78
https://doi.org/10.1016/j.mencom.2018.11.007
https://doi.org/10.1016/j.mencom.2018.11.007
Publikováno v:
Tetrahedron. 68:6868-6872
A simple and effective synthesis of the chiral thiazole-containing fragment of an epothilone D analogue from (−)-carvone is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aab885f68131b3cad566f9a903e9dc0
https://doi.org/10.1016/j.tet.2012.06.020
https://doi.org/10.1016/j.tet.2012.06.020