Výsledky vyhledávání - "R. F. Struck"

Phase I and pharmacologic study of penclomedine, a novel alkylating agent, in patients with solid tumors

Autor: R F Struck, Eric K. Rowinsky, K Bowling, Louise B. Grochow, N R Hartman, Seamus O'Reilly, T L Chen, Ross C. Donehower

Publikováno v: Journal of Clinical Oncology. 15:1974-1984

PURPOSE To determine the maximum-tolerated dose (MTD), principal toxicities, and pharmacologic behavior of penclomedine, a novel alkylating agent. PATIENTS AND METHODS Penclomedine (45 to 550 mg/ m2/d every 3 weeks) was administered as a 1- or 3-hour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f2f9390d57ad6dc94868a396aa4441
https://doi.org/10.1200/jco.1997.15.5.1974

Zobrazit plný text záznamu

4-Demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine

Autor: W R, Waud, A, Tiwari, S M, Schmid, T W, Shih, J M, Strong, N R, Hartman, S, O'Reilly, R F, Struck

Publikováno v: Cancer research. 57(5)

Penclomedine [3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine], an antitumor agent, is currently in Phase I clinical trials and is believed to be a prodrug. In these studies, cerebellar effects have been dose limiting. Previous studies identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab7dca5383d055e45d519b94a98582ca
https://pubmed.ncbi.nlm.nih.gov/9041177

Zobrazit plný text záznamu

Tissue and tumor distribution of C-penclomedine in rats

Autor: S, O'Reilly, N R, Hartman, S A, Grossman, J M, Strong, R F, Struck, S, Eller, G J, Lesser, R C, Donehower, E K, Rowinsky

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(3)

Penclomedine, a lipophilic alpha-picoline derivative, is undergoing clinical development presently because of its pronounced antitumor activity against intracerebral (i.c.) tumor xenografts. Penclomedine may be metabolized in vivo to a more potent co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bfcc8f715987f0d88ccd934b68e3bdc
https://pubmed.ncbi.nlm.nih.gov/9816201

Zobrazit plný text záznamu

A novel class of mono-alkylating agents with highly potent and selective tumor cell growth inhibitory activity

Autor: L. U. Coward, Adam B. Keeton, Heather N. Tinsley, Ashraf H. Abadi, Nan Li, Bernard D. Gary, Greg Gorman, K. N. Tiwari, R. F. Struck, M. R. Knight, Gary A. Piazza, W. R. Waud, Wei Zhang

Publikováno v: Journal of Clinical Oncology. 29:e13523-e13523

e13523 Background: Recent studies have shown that siRNA knockdown of the cGMP-specific phosphodiesterase, PDE5 can suppress growth and induce apoptosis of human breast tumor cells. However, convent...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::837ad95f626021c4c35c3edeab5a0f52
https://doi.org/10.1200/jco.2011.29.15_suppl.e13523

Zobrazit plný text záznamu

Metabolism and disposition of a thiazolobenzimidazole active against human immunodeficiency virus-1

Autor: S M, el Dareer, K F, Tillery, L M, Rose, C F, Posey, R F, Struck, S W, Stiller, D L, Hill

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(2)

This study was undertaken to evaluate the disposition of the thiazolobenzimidazole, 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole (TZB), which has promising antiviral activity. For mice, the maximum tolerated intravenous dose of TZB was 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60a6bb3c3ae9fc1fd9f8d45580e12684
https://pubmed.ncbi.nlm.nih.gov/8097690

Zobrazit plný text záznamu

Disposition and metabolism of carbovir in mice dosed intravenously or orally

Autor: S M, el Dareer, K F, Tillery, L M, Rose, R F, Struck, D L, Hill

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(6)

To determine the disposition of carbovir and [3H]carbovir in mice, HPLC and thin-layer chromatographic assays were developed and mice were dosed iv and by gavage. Carbovir had no lethal effect at iv doses up to 500 mg/kg and was stable for 24 hr in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e2ec4d78d7e924453f0d6fe74da91dc
https://pubmed.ncbi.nlm.nih.gov/1981526

Zobrazit plný text záznamu

Effect of phenobarbital on plasma levels of cyclophosphamide and its metabolites in the mouse

Autor: Y. M. Peng, R. F. Struck, H. S. Chen, D. S. Alberts

Publikováno v: British Journal of Cancer

We have studied the quantitative pharmacokinetic differences of individual metabolites and unchanged cyclophosphamide (CPA) in control and phenobarbital-treated animals, using radiolabelled CPA together with thin-layer chromatography. On Day 0, one g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47359571d0b8b2bc74f154f4aebfd83c
https://doi.org/10.1038/bjc.1978.204

Zobrazit plný text záznamu

Isophosphoramide mustard, a metabolite of ifosfamide with activity against murine tumours comparable to cyclophosphamide

Autor: R F Struck, W J Suling, M W Trader, T H Corbett, D J Dykes

Publikováno v: British Journal of Cancer

Isophosphoramide mustard was synthesized and was found to demonstrate activity essentially comparable to cyclophosphamide and ifosfamide against L1210 and P388 leukaemia. Lewis lung carcinoma, mammary adenocarcinoma 16/C, ovarian sarcoma M5076, and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff383ee3d47d2509051bf689ddaf75f
https://doi.org/10.1038/bjc.1983.2

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání